Mechatronically guided micro navigation for soft tissue needle insertion
用于软组织针插入的机电引导微导航
基本信息
- 批准号:240636000
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2014
- 资助国家:德国
- 起止时间:2013-12-31 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The insertion of needles represents an interesting alternative for minimally invasive and focusses diagnosis and therapy in soft tissues, e.g., including biopsies or brachytherapy. However, needle insertion often causes substantial soft tissue deformation, which can result in a misplacement of the needle relative to the tissue. In a first project phase, we realized a mechatronic setup to prove feasibility of high resolution optical navigation from within the needle. Using fiber optic components integrated into the needle, we obtain high resolution optical coherence tomography images of the tissue surrounding the needle. Particularly, it is possible to detect even small deformations of the tissue and to estimate the relative motion between needle and tissue. In a second project phase the resulting tissue model will be extended to include elastic tissue properties and even higher resolution spatial information. One objective is to estimate the information needed to model and predict the needle-tissue interaction from within the needle. In combination with the mechatronic needle driving, this will form the basis for a precise control of the needle motion accounting for tissue deformation. Another aspect regards the possible differentiation of different tissues. For example, the elastic tissue properties are also related to the type of tissue, e.g., tumor tissue is often less elastic. To also consider structural differences in the tissue, we will first integrate optical coherence microscopy into a needle probe. A longer term objective is using the morphological and mechanic tissue model for localization and treatment planning.
针的插入代表了用于微创的令人感兴趣的替代方案,并且将诊断和治疗集中在软组织中,例如,包括活组织检查或近距离放射治疗。然而,针插入通常会引起实质性的软组织变形,这可能导致针相对于组织的错位。在第一个项目阶段,我们实现了机电一体化设置,以证明从针内进行高分辨率光学导航的可行性。使用集成到针中的光纤组件,我们获得针周围组织的高分辨率光学相干断层扫描图像。特别地,可以检测组织的甚至很小的变形并且估计针和组织之间的相对运动。在第二个项目阶段,所得到的组织模型将被扩展到包括弹性组织特性和甚至更高分辨率的空间信息。一个目标是估计建模和预测针内针与组织相互作用所需的信息。与机电针驱动相结合,这将形成考虑组织变形的针运动的精确控制的基础。另一个方面涉及不同组织的可能分化。例如,弹性组织特性还与组织类型有关,例如,肿瘤组织通常弹性较小。为了考虑组织中的结构差异,我们将首先将光学相干显微镜集成到针探针中。长期目标是使用形态学和力学组织模型进行定位和治疗计划。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography.
用于体积多兆赫光学相干断层扫描的高速光纤扫描内窥镜
- DOI:10.1364/ol.43.004386
- 发表时间:2018
- 期刊:
- 影响因子:3.6
- 作者:Schulz-Hildebrandt H;Pfeiffer T;Eixmann T;Lohmann S;Ahrens M;Rehra J;Draxinger W;König P;Huber R;Hüttmann G
- 通讯作者:Hüttmann G
Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination
用于体内粘膜检查的基于音圈的显微光学相干断层扫描探头
- DOI:10.1117/12.2578787
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Ahrens M;Idel C;König P;Hüttmann G;Schulz-Hildebrandt H
- 通讯作者:Schulz-Hildebrandt H
In-vivo markerless motion detection from volumetric optical coherence tomography data using CNNs
使用 CNN 根据体积光学相干断层扫描数据进行体内无标记运动检测
- DOI:10.1117/12.2581023
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Sprenger J;Neidhardt M;Schlüter M;Latus S;Gosau T;Kemmling J;Feldhaus S;Schumacher U;Schlaefer A
- 通讯作者:Schlaefer A
Force estimation from 4D OCT data in a human tumor xenograft mouse model
根据人类肿瘤异种移植小鼠模型中的 4D OCT 数据进行力估计
- DOI:10.1515/cdbme-2020-0022
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Neidhardt M;Gessert N;Gosau T;Kemmling J;Feldhaus S;Schumacher U;Schlaefer A
- 通讯作者:Schlaefer A
Spatio-temporal deep learning models for tip force estimation during needle insertion
- DOI:10.1007/s11548-019-02006-z
- 发表时间:2019-09-01
- 期刊:
- 影响因子:3
- 作者:Gessert, Nils;Priegnitz, Torben;Schlaefer, Alexander
- 通讯作者:Schlaefer, Alexander
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Professor Dr. Gereon Hüttmann其他文献
Professor Dr. Gereon Hüttmann的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Professor Dr. Gereon Hüttmann', 18)}}的其他基金
Holographic optical coherence tomography (OCT) for functional retina imaging
用于功能性视网膜成像的全息光学相干断层扫描 (OCT)
- 批准号:
392443200 - 财政年份:
- 资助金额:
-- - 项目类别:
Research Grants
相似海外基金
Ectopic Olfactory Receptor Guided Facial Nerve Regeneration
异位嗅觉受体引导面神经再生
- 批准号:
10575837 - 财政年份:2023
- 资助金额:
-- - 项目类别:
A new multi-scale x-ray micro computed tomography machine to enable (image-guided) non-destructive inspections of decellularised tissue
新型多尺度 X 射线微型计算机断层扫描机,可对脱细胞组织进行(图像引导)无损检查
- 批准号:
EP/T029080/1 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Research Grant
Light-sheet micro-aspiration microscopy for the isolation and analysis of rare tumor cells from intact clinical specimens
光片微抽吸显微镜用于从完整的临床标本中分离和分析稀有肿瘤细胞
- 批准号:
10682604 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Light-sheet micro-aspiration microscopy for the isolation and analysis of rare tumor cells from intact clinical specimens
光片微抽吸显微镜用于从完整的临床标本中分离和分析稀有肿瘤细胞
- 批准号:
9804527 - 财政年份:2019
- 资助金额:
-- - 项目类别:
SARRP 200 Platform for Image Guided Micro Irradiation
SARRP 200 图像引导微辐照平台
- 批准号:
9075077 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Advanced micro-PET/CT/RT System for Translational Radiation Oncology Applications
用于转化放射肿瘤学应用的先进微型 PET/CT/RT 系统
- 批准号:
9249366 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Electric Field Guided Micro Additive Manufacturing Process
电场引导微增材制造工艺
- 批准号:
1463411 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Standard Grant
Microfabrication Platform for Guided-Wave Optics and Micro-electro-mechanical Systems Integration
导波光学和微机电系统集成微加工平台
- 批准号:
470175-2014 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Collaborative Research and Development Grants
Advanced micro-PET/CT/RT System for Translational Radiation Oncology Applications
用于转化放射肿瘤学应用的先进微型 PET/CT/RT 系统
- 批准号:
8962231 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Microfabrication Platform for Guided-Wave Optics and Micro-electro-mechanical Systems Integration
导波光学和微机电系统集成微加工平台
- 批准号:
470175-2014 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Collaborative Research and Development Grants














{{item.name}}会员




