I-Corps: Self-oxygen generating biomaterial and a biocompatible electrochemical device to generate oxygen for tissue engineering

I-Corps：自产氧生物材料和生物相容性电化学装置，为组织工程产生氧气

• 批准号: 2005317
• 负责人: Iman Noshadi
• 金额: $ 5万
• 依托单位: Rowan University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-15 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2005317&HistoricalAwards=false
• 关键词: Corps; Self; oxygen; generating; biomaterial

The broader impact/commercial potential of this I-Corps project will be the development of a 3D printed, oxygen generating device for cardiac tissue engineering. Cardiovascular disease remains the number one reason for death in the US and across the world. An AHA study suggests that by 2035, nearly 45% of Americans will have developed cardiac problems that cost up about $2B per annum. The current standard of care is organ transplantation, which is beleaguered by a shortage of organs and donors, expensive, and requiring life-long immunosuppression. Alternatively, it may be possible to address the treatment of cardiac problems using tissue engineering (TE). TE is limited by tissue death in large-sized and 3D constructs brought about by inadequate oxygen and nutrient supply. The technology under development is aimed at solving this problem to advance TE as a treatment solution for cardiac repair.This I-Corps project is based on the development of a self-oxygen generating biomaterial and a biocompatible electrochemical device designed to generate oxygen for the application of tissue engineering. This device design will be printed as 3D cardiac tissue structures, wherein the oxygen generation ability will prevent cell death in the scaffold center. This is currently the primary impediment for the use of tissue engineering in myocardial repair. The innovation is expected to reduce both organ replacement costs and post-operative costs for immune-suppression and care. In the near future, the technology may be extended to other biological tissues. The material platform and device design under development also may be applied to other biomedical applications, including sensors, actuators, and other healthcare devices.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目更广泛的影响/商业潜力将是开发用于心脏组织工程的3D打印氧气生成设备。心血管疾病仍然是美国和世界各地死亡的头号原因。AHA的一项研究表明，到2035年，近45%的美国人将出现心脏问题，每年花费约20亿美元。目前的护理标准是器官移植，这是困扰着器官和捐赠者短缺，昂贵，并需要终身免疫抑制。或者，它可能是可能的，以解决使用组织工程（TE）的心脏问题的治疗。 TE受限于大尺寸和3D结构中由氧气和营养供应不足引起的组织死亡。正在开发的技术旨在解决这一问题，以推进TE作为心脏修复的治疗解决方案。I-Corps项目基于开发自产氧生物材料和生物相容性电化学装置，旨在为组织工程应用产生氧气。该装置设计将被打印为3D心脏组织结构，其中氧气生成能力将防止支架中心的细胞死亡。 这是目前组织工程在心肌修复中应用的主要障碍。这项创新预计将降低器官置换成本和免疫抑制和护理的术后成本。在不久的将来，该技术可能会扩展到其他生物组织。正在开发的材料平台和设备设计也可以应用于其他生物医学应用，包括传感器，执行器和其他医疗设备。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。