PFI-TT: Development of Highly Adhesive Hydrogel for Cornea Tissue Regeneration

PFI-TT：开发用于角膜组织再生的高粘附性水凝胶

• 批准号: 2137727
• 负责人: Iman Noshadi
• 金额: $ 25万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2137727&HistoricalAwards=false
• 关键词: PFI; TT; Development; Highly; Adhesive

The broader impact/commercial potential of this Partnerships for Innovation-Technology Translation (PFI-TT) project is a new biocompatible, antimicrobial and transparent adhesive for corneal repair and grafting that will significantly reduce costs of extended and secondary treatment associated with current standards of care. Of the 2.4 million eye injuries yearly in the US, 600,000 are open globe corneal tears, leading to blindness in 50,000 cases. There are 18 million cases of such blindness worldwide. The annual corneal grafting market is 40,000 procedures nationally and an estimated 185,000 worldwide. The proposed product is expected to circumvent the limitations of current surgical approaches and postoperative cost and care in corneal repair. This would result in cost savings for the entire ecosystem, such as patients, insurance companies (including Medicare), and hospitals. The commercialization potential in the US and world markets can potentially generate job opportunities in research and development, marketing, and manufacturing. Additional technical teaching and outreach opportunities involving students from underrepresented backgrounds, women, minorities, and people with disabilities are targeted with this project work. The proposed project presents a biocompatible and antimicrobial bioadhesive for corneal repair and grafting. Current standards of care include suturing and cyanoacrylate glue, which suffers from additional treatment costs related to astigmatism, secondary infections, cytotoxicity, and retinopathy. The proposed product is expected to mitigate these secondary problems with its biocompatibility, high adhesion, flexibility, and high strength. The adhesive will rapidly integrate corneal cells to facilitate wound sealing, reducing the chances of secondary infection and the associated incremental hospitalization and medication costs. The material transparency will enable rapid vision restoration. The material is strongly adhesive and antimicrobial, preventing accidental removal and offering excellent stability and high retention. The goals of this project will be accomplished with three main tasks. In the first task, the team will systematically explore the effect of experimental conditions on bioadhesive characteristics, such as tissue adhesion, biocompatibility, flexibility, transparency, and antibacterial properties. In the second task, degradation and retention of the bioadhesive will be determined by investigating the changes when applied to corneal tears. In the third task, the integrative capacity of the bioadhesive in vivo will be assessed by studying its effects on corneal cells, as well as the migration of corneal cells into the bioadhesive over time.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这种伙伴关系对创新技术翻译（PFI-TT）项目的更广泛的影响/商业潜力是一种新的生物相容性，抗菌和透明的粘合剂，可用于角膜维修和嫁接，可显着降低与当前护理标准相关的扩展和次要治疗的成本。在美国每年240万只眼睛受伤中，有60万是开放的地球角膜眼泪，导致50,000例失明。全球有1800万例这种失明。年度角膜嫁接市场是全国40,000个程序，全球估计是185,000个程序。预计该提议的产品将避免当前手术方法的局限性以及角膜修复中的术后成本和护理。这将节省整个生态系统，例如患者，保险公司（包括医疗保险）和医院。 美国和世界市场的商业化潜力可能会在研发，营销和制造业中产生就业机会。 这项项目工作涉及来自代表性不足的背景，妇女，少数民族和残疾人的其他技术教学和外展机会。拟议的项目提出了一种生物相容性和抗菌生物粘附，用于角膜修复和嫁接。当前的护理标准包括缝合和氰基丙烯酸酯胶，其中遭受了与散光，继发感染，细胞毒性和视网膜病有关的额外治疗成本。预计该提出的产品将通过其生物相容性，高粘附，柔韧性和高强度来减轻这些次要问题。粘合剂将迅速整合角膜细胞，以促进伤口密封，减少继发感染的机会以及相关的增量住院和药物成本。 材料透明度将实现快速视力恢复。该材料具有强烈的粘合剂和抗菌剂，可防止意外去除并提供出色的稳定性和高保留率。该项目的目标将通过三个主要任务来实现。在第一个任务中，团队将系统地探索实验条件对生物粘附特性的影响，例如组织粘附，生物相容性，灵活性，透明度和抗菌特性。在第二个任务中，生物粘附的降解和保留将通过研究将变化应用于角膜撕裂时确定。在第三任任务中，将通过研究其对角膜细胞的影响以及角膜细胞随时间的迁移以及角膜细胞向生物粘附的迁移来评估体内的综合能力。该奖项反映了NSF的法定任务，并通过使用该基金会的智力优点和广泛的影响来评估NSF的法定任务，并被视为值得通过评估的支持。

项目成果

In situ 3D printing of implantable energy storage devices

• DOI: 10.1016/j.cej.2020.128213
• 发表时间: 2021-04-01
• 期刊: CHEMICAL ENGINEERING JOURNAL
• 影响因子: 15.1
• 作者: Krishnadoss, Vaishali;Kanjilal, Baishali;Noshadi, Iman
• 通讯作者: Noshadi, Iman

Bioionic Liquids: Enabling a Paradigm Shift Toward Advanced and Smart Biomedical Applications

• DOI: 10.1002/aisy.202200306
• 发表时间: 2023-02
• 期刊: Advanced Intelligent Systems
• 影响因子: 7.4
• 作者: Baishali Kanjilal;Yangzhi Zhu;Vaishali Krishnadoss;Janitha M. Unagolla;Parnian Saemian;Alessia Caci;Danial Cheraghali;Iman Dehzangi;A. Khademhosseini;Iman Noshadi

Programmable bio-ionic liquid functionalized hydrogels for in situ 3D bioprinting of electronics at the tissue interface

• DOI: 10.1016/j.mtadv.2023.100352
• 发表时间: 2023-03
• 期刊: Materials Today Advances
• 影响因子: 10
• 作者: Vaishali Krishnadoss;Baishali Kanjilal;A. Masoumi;A. Banerjee;Iman Dehzangi;A. Pezhouman;R. Ardehali-R.-Ardeh