权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Grid Cell Spatial Periodicity: Necessary Intercellular Interactions during Development and Behavioral Function

网格细胞空间周期性：发育和行为功能过程中必要的细胞间相互作用

基本信息

批准号：
241670582
负责人：
Dr. Kevin Allen
金额：
--
依托单位：
Biotech Research and Innovation Centre (BRIC)
依托单位国家：
德国
项目类别：
Independent Junior Research Groups
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2019-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/241670582?language=en
关键词：
Grid Cell Spatial Periodicity Necessary

项目摘要

Spatial behaviors in mammals depend on internal spatial representations generated in several interconnected brain regions. A striking example is found in the medial entorhinal cortex (MEC). The main building blocks of the MEC spatial representation are grid cells, which fire only when the position of an animal corresponds to the vertices of a grid of equilateral triangles. Although the firing of grid cells during exploratory behavior is now well characterized, the network mechanisms responsible for the spatial periodicity of grid cells and the possible function of grid cells at the behavioral level are not known. The current project has three main objectives. Firstly, we will test whether intercellular interactions via electrical and chemical synapses early during development play an important role in the formation of grid cell spatial periodicity. Secondly, we will characterize the activity of a group of MEC neurons expressing somatostatin and investigate how they interact with grid cells. Thirdly, we will test the main hypothesis regarding the behavioral function of grid cell spatial periodicity, namely, that grid cell periodicity is essential for path integration. Our experimental approach will combine temporally-regulated gene silencing, optogenetics, in vivo recordings and spatial navigation tests. This work will advance our understanding of the network mechanisms behind the spatial representation of the MEC and will help to clarify the role of grid cells in spatial behavior.

哺乳动物的空间行为依赖于几个相互连接的大脑区域产生的内部空间表征。内侧内嗅皮层（MEC）就是一个显著的例子。MEC空间表征的主要构建块是网格单元，只有当动物的位置与等边三角形网格的顶点相对应时，网格单元才会激活。虽然在探索行为中，网格细胞的放电已经被很好地表征，但导致网格细胞空间周期性的网络机制以及网格细胞在行为水平上的可能功能尚不清楚。当前的项目有三个主要目标。首先，我们将测试发育早期通过电突触和化学突触的细胞间相互作用是否在网格细胞空间周期性的形成中发挥重要作用。其次，我们将描述一组表达生长抑素的MEC神经元的活性，并研究它们如何与网格细胞相互作用。第三，我们将验证关于网格单元空间周期性行为功能的主要假设，即网格单元周期性对路径积分至关重要。我们的实验方法将结合暂时调节的基因沉默，光遗传学，体内记录和空间导航测试。这项工作将促进我们对MEC空间表征背后的网络机制的理解，并有助于阐明网格细胞在空间行为中的作用。