Advanced Research Training in Physiology - Integrating Biology Across the Scales

生理学高级研究培训 - 跨尺度整合生物学

• 批准号: 2014108
• 负责人: Linda Hyman
• 金额: $ 85.26万
• 依托单位: Marine Biological Laboratory
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2014108&HistoricalAwards=false
• 关键词: Advanced; Research; Training; Physiology; Integrating

pFounded in 1892, The Marine Biology Laboratory (MBL) Physiology Course is one of the oldest, continually-running biology courses in the World. This training course remains a "Gold Standard" for bringing together faculty, and students selected from a highly qualified pool, across many disciplines in the life sciences. The instructors work closely as a cohesive team to educate early-career biologists, many of whom go on to make their own ground-breaking discoveries. The MBL Physiology Course fosters a unique training environment that uses cellular, molecular, and physical principles of biology to understand living organisms. This NSF award will be used to integrate cellular and genomic science with principles and practices of organismal and evolutionary biology. Faculty and students will combine their unique perspectives to problem solving in physiology. By so doing, a deeper understanding of the physiological principles of "How Life Works" will be attained and integrated across biological subdisciplines. To extend the learning experience beyond the time that each trainee spends at the MBL, instructors in the MBL Physiology Course will invite and support teams of students to continue to work together after they return to their respective research groups at their home institutions. Through this post-course experience, each participant will have the opportunity to engage and educate the general public regarding fundamental principles of living organisms, related to the societal importance of new knowledge and discovery in the life sciences./p pThe MBL Physiology Course provides intensive training and research experiences at critical intersections of cell biology and physical science - ranging from molecular biology, genetics, genomics, to evolutionary biology. The course begins with an intensive "Boot Camp," when biologists, physicists, and all students become familiar with cutting-edge techniques in cellular anatomy and physiology, fabrication, bioinformatics, while working together to analyze big data sets. The revised MBL Physiology Course will now incorporate interactions with three other concurrent summer courses to bring physiology "back into the organism" and challenge students to consider cells in their natural contexts. Intentionally bringing students together from the Physiology, Microbial Diversity, Embryology, and Biology of Parasites courses will provide opportunities for synergism of ideas and expanded multidisciplinary perspectives inherent in this horizontal integration across biological subdisciplines. The MBL Physiology Course trains a diverse student body, with specific attention given to the recruitment and support of under-represented groups in STEM. In addition, the course will aid students in disseminating techniques and concepts via support of organized groups at the students' home institutions and at scientific conferences./p pThis award is cofunded by the Division of Integrative Organismal Systems and the Division of Molecular and Cellular Biosciences./p pThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria./p

海洋生物学实验室（MBL）生理学课程成立于1892年，是世界上最古老的，持续运行的生物学课程之一。该培训课程仍然是汇集教师的“黄金标准”，从高素质的人才库中挑选学生，跨越生命科学的许多学科。教师们密切合作，作为一个有凝聚力的团队，教育早期职业生物学家，其中许多人继续使自己的突破性发现。MBL生理学课程培养了一个独特的训练环境，使用生物学的细胞，分子和物理原理来了解生物体。该奖项将用于整合细胞和基因组科学与有机体和进化生物学的原则和实践。教师和学生将联合收割机结合自己的独特观点，解决生理学问题。通过这样做，对“生命如何运作”的生理学原理的更深入理解将在生物学分支学科中实现和整合。为了将学习经验扩展到每个学员在MBL度过的时间之外，MBL生理学课程的教师将邀请并支持学生团队在他们返回各自的研究小组后继续共同工作。通过这一课程后的经验，每个参与者将有机会参与和教育公众关于生物体的基本原则，与生命科学新知识和发现的社会重要性有关。p p MBL生理学课程提供细胞生物学和物理科学关键交叉点的强化培训和研究经验-从分子生物学，遗传学，基因组学到进化生物学。该课程以密集的“靴子营”开始，当生物学家，物理学家和所有学生熟悉细胞解剖学和生理学，制造，生物信息学的前沿技术，同时共同分析大数据集。修订后的MBL生理学课程现在将与其他三个并行的夏季课程进行互动，将生理学“带回生物体”，并挑战学生在自然环境中考虑细胞。有意将学生从生理学，微生物多样性，胚胎学和寄生虫生物学课程聚集在一起，将为思想的协同作用提供机会，并扩大跨生物学科横向整合所固有的多学科视角。MBL生理学课程培养了多样化的学生群体，特别关注STEM中代表性不足的群体的招聘和支持。此外，该课程还将通过学生所在机构和科学会议上的有组织团体的支持，帮助学生传播技术和概念。p p该奖项由综合有机系统部和分子与细胞生物科学部共同资助。/ p p该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。/ p