权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Workshop: Microbial Diversity Molecules to Modeling Across Biological Scales; Summers, Woods Hole, MA

研讨会：微生物多样性分子跨生物尺度建模；

基本信息

批准号：
1822263
负责人：
Linda Hyman
金额：
$ 24.61万
依托单位：
Marine Biological Laboratory
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2022-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1822263&HistoricalAwards=false
关键词：
Workshop Microbial Diversity Molecules Modeling

项目摘要

Microorganisms such as bacteria, viruses and other single cell organisms, are emerging as key engineering components for solving global societal problems, ranging from human health, to energy, to providing clean water to more than one billion people who currently live without it. This is because, during their nearly 4-billion-year history, microbes have "invented" numerous metabolic reactions that have transformed the Earth's environment. To understand these processes, their impacts on the ecosystem, and to harness them for societal benefits requires a multidisciplinary approach. Microbial Diversity is an advanced research training program at the Marine Biological Laboratory (MBL) that augments traditional PhD and postdoctoral training through an intensive 6.5 week, immersive experience that occurs in the peak summer months when prominent scientists across biological disciplines convene at MBL. This research-training program teaches cutting-edge methods and concepts that impact microbial ecology, ecosystem function and animal-associated microbiomes. To accomplish these goals, participants will receive broad research training at the forefront of microbiological sciences, research ethics and scientific outreach to the public. This experience has broad impacts for the following reasons: 1) The transformative nature of the program enhances retention in research and academic positions; 2) Mentoring postdoctoral trainees in curriculum development provides valuable teaching experience; 3) Participants from underrepresented groups in science will contribute towards the diversification of the scientific workforce. Research products that will emerge from the course include publicly-available resources and cultured isolates of bacteria, viruses and other microorganisms. Many students from this research-training program go on to be leaders in research that incorporates microbial biodiversity, and in at the intersection of science and society. This research-training experience integrates training across biological scales; from understanding one metabolic pathway in a single organism, to dynamics of single cells in a population, to understanding the impact of microbes on the ecosystem scale. The goal of this program is to integrate training from the disciplines of microbiology, ecology, evolution, chemistry, computational science, and bioinformatics in order to shape the future leaders of microbial diversity science. This is accomplished by integrating modeling, experimentation, and function with emerging cellular properties across broad spatio-temporal scales in order to be able to predict the behavior of living cells in natural systems. In the next three years, specific training will be offered in: (i) cultivation that leverages information from the vast, publicly-available sequence databases, with a focus on novel eukaryotes, viruses, and microbial consortia, (ii) isolating and characterizing the role of viruses in microbial diversity, function and ecology; (iii) quantitative tools and modeling of high-resolution changes of metabolic fluxes in time and space. The objectives of this research-training experience are as follows: (i) Participants will receive broad research training in transformative theoretical and applied approaches at the forefront of microbiological sciences, through a combination of classroom, workshop, and laboratory-based didactic activities; (ii) Intensive and ongoing longitudinal explorations of marine, freshwater and host-associated microbial communities will be integrated to identify microbial dynamics over a five-year time series of publicly available data, and (iii) Postdoctoral researchers will receive direct experience in active learning in the classroom and laboratory.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

微生物，如细菌、病毒和其他单细胞生物，正在成为解决全球社会问题的关键工程组件，从人类健康到能源，再到为目前没有水的10亿多人提供清洁水。这是因为，在近40亿年的历史中，微生物“发明”了许多改变地球环境的代谢反应。为了了解这些过程及其对生态系统的影响，并利用它们来实现社会效益，需要采取多学科的方法。微生物多样性是海洋生物实验室（MBL）的一项高级研究培训计划，该计划通过为期6.5周的密集，身临其境的体验来增强传统的博士和博士后培训，该体验发生在夏季高峰期，当时跨生物学科的杰出科学家在MBL召开会议。该研究培训计划教授影响微生物生态学，生态系统功能和动物相关微生物组的尖端方法和概念。为了实现这些目标，参与者将在微生物科学，研究伦理和科学推广到公众的最前沿接受广泛的研究培训。这种经验具有广泛的影响，原因如下：1）该计划的变革性质增强了研究和学术职位的保留; 2）在课程开发中指导博士后学员提供了宝贵的教学经验; 3）来自科学代表性不足群体的参与者将有助于科学劳动力的多样化。该课程将产生的研究产品包括公共资源和细菌，病毒和其他微生物的培养分离物。来自这个研究培训计划的许多学生继续成为结合微生物生物多样性的研究的领导者，并处于科学与社会的交叉点。这种研究培训经验整合了跨生物尺度的培训;从了解单个生物体中的一种代谢途径，到群体中单个细胞的动态，再到了解微生物对生态系统规模的影响。该计划的目标是整合微生物学，生态学，进化，化学，计算科学和生物信息学等学科的培训，以塑造微生物多样性科学的未来领导者。这是通过将建模、实验和功能与跨时空尺度的新兴细胞特性相结合来实现的，以便能够预测自然系统中活细胞的行为。在未来三年内，将提供以下方面的具体培训：（i）利用来自庞大的公开序列数据库的信息进行培养，重点是新的真核生物，病毒和微生物财团，（ii）分离和表征病毒在微生物多样性，功能和生态中的作用;（iii）定量工具和代谢通量在时间和空间中的高分辨率变化建模。㈠通过课堂、讲习班和实验室教学活动相结合的方式，参加者将接受微生物科学前沿变革性理论和应用方法方面的广泛研究培训; ㈡进行深入和持续的海洋纵向勘探，淡水和宿主相关的微生物群落将被整合，以确定五年时间序列的公开数据中的微生物动态，以及（iii）博士后研究人员将在课堂和实验室中获得积极学习的直接经验。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响进行评估，被认为值得支持审查标准。