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Rolled-Up Microsystems

卷起的微系统

基本信息

批准号：
242694901
负责人：
Professor Dr. Jan Gerrit Korvink
金额：
--
依托单位：
CEA Centre de Saclay
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2016-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/242694901?language=en
关键词：
Rolled Up Microsystems

项目摘要

The RUM consortium will develop a novel micro-technology approach, based on the self-rolling of thin polymeric films, that will result in an extensive micro-engineering process with a high degree of dimensional and morphological control.The research will be based upon a theoretical prediction of the rolling process for non-trivial geometries and morphologies, as well as for each of the relevant processing steps, and a correlation of the predictions with experimental findings.The RUM consortium will combine self-rolling with functional and metal ink-jetting including subsequent galvano-forming to achieve unique inner-tube decoration with micro-devices. The process development will be focused on novel applications that are enabled by this new approach, and will demonstrate the high potential of the technology.The basis application will be an extensive and when required optically transparent lab-on-a-chip infrastructure that lies on top of rather than embedded in the carrier substrate. The above-surface micro-fluidic networks will be augmented by cell-biological functions requiring smooth non- rectangular micro-tubes and patterned chemical decoration of the inner tube surfaces. Through the use of 2 photon polymerisation, unique 3D herringbone-like chaotic flow mixer structures will be formed which should yield a new fluid dynamic understanding and higher degree of fluidic mixing that currently possible in micromixers.The micro-fluidic channels will contain unique and precisely formed Alderman-Grant nuclear magnetic resonance (NMR) detector structures within the tubes, and connected to passives and micro-coaxial cables, that will enable high resolution NMR spectrum (MRS) and imaging (MRI) capabilities whilst at the same time performing microfluidic-based cell-proliferation studies. The RUM consortium will also develop structures with which to connect the fluidic and radiofrequency devices to the outside world.Taken together, we aim to demonstrate unprecedented precision and parallelization of this novel lab-on-a-chip functionality, and if successful, aim to open up brand new areas of investigation.

RUM联盟将开发一种基于聚合物薄膜自滚动的新型微技术方法，这将导致具有高度尺寸和形态控制的广泛的微工程过程。该研究将基于对非平凡几何形状和形态以及每个相关加工步骤的滚动过程的理论预测，以及预测与实验的相关性。研究结果。RUM 联盟将把自滚动与功能性和金属喷墨相结合，包括随后的电镀成型，以通过微型器件实现独特的内管装饰。工艺开发将侧重于这种新方法所实现的新颖应用，并将展示该技术的巨大潜力。基础应用将是一个广泛的、需要时光学透明的片上实验室基础设施，该基础设施位于载体基板之上而不是嵌入在载体基板中。表面上的微流体网络将通过需要光滑的非矩形微管和内管表面的图案化化学装饰的细胞生物学功能来增强。通过使用 2 光子聚合，将形成独特的 3D 人字形混沌流混合器结构，这应该产生新的流体动力学理解和目前在微混合器中可能实现的更高程度的流体混合。微流体通道将在管内包含独特且精确形成的 Alderman-Grant 核磁共振 (NMR) 检测器结构，并连接到无源器件和微同轴电缆，将实现高分辨率核磁共振谱（MRS）和成像（MRI）功能，同时进行基于微流体的细胞增殖研究。 RUM 联盟还将开发用于将流体和射频设备连接到外界的结构。总之，我们的目标是展示这种新颖的芯片实验室功能前所未有的精度和并行性，如果成功，我们的目标是开辟全新的研究领域。