MRI: Acquisition of Single Crystal X-ray Diffractometer to Support Undergraduate Research in Chemistry

MRI：购买单晶 X 射线衍射仪以支持化学本科生研究

• 批准号: 2018561
• 负责人: Deidra Gerlach
• 金额: $ 10.25万
• 依托单位: University of Wisconsin-Eau Claire
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018561&HistoricalAwards=false
• 关键词: MRI; Acquisition; Single; Crystal; ray

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of Wisconsin-Eau Claire is acquiring a benchtop, single-crystal X-ray diffractometer to support Professor Deidra Gerlach and colleague Jason Halfen. This diffractometer allows research in a variety of fields of significant economic importance such as catalysis which is important to advance manufacturing. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles. The instrument also provides accurate information about the spatial arrangement of a molecule relative to neighbors. The studies to be performed may impact many areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution as well other departments. The science enabled by this instrument has the potential to impact society.Crystallographic studies of compounds prepared by students will foster students' engagement in the research enterprise and lead to an enhanced frequency and quality of research products, including student coauthored publications and extramural presentations. By making in-house structure determination routine, the instrument will provide a significant boost to student development and preparation for advanced coursework and entry into graduate programs. The instrument will promote significant outreach and collaborative possibilities by providing crystallographic support to the researchers of nearby campuses providing long-term impact on ongoing departmental efforts to enhance the recruitment and retention of women, low income/first generation college students, and members of underrepresented groups to pursue coursework and careers in the chemical sciences, part of a broader institutional emphasis to recruit and retain a diverse, inclusive student body.The award of the X-ray diffractometer is aimed at enhancing research and education at all levels. It especially impacts studies of effects of structural variation on organometallic catalysis. The instrumentation is used to analyze conformation and configuration effects of fluorophores. In addition, it provides information on benzylidenecamphore organocatalysts. The diffractometer is also used to study the mechanism of the Vitamin K cycle.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。威斯康星大学奥克莱尔分校正在购买一台台式单晶X射线衍射仪，以支持Deidra盖拉赫教授和同事Jason Halfen。这种衍射仪可以在各种具有重要经济意义的领域进行研究，例如对推进制造业很重要的催化作用。一般来说，X射线衍射仪可以精确测量分子的完整三维结构，包括键距和键角。 该仪器还提供了关于分子相对于相邻分子的空间排列的准确信息。要进行的研究可能会影响许多领域，包括有机和无机化学，材料化学和生物化学。该仪器是该机构以及其他部门的化学和生物化学本科生的教学和研究及研究培训的组成部分。该仪器所支持的科学具有影响社会的潜力。对学生制备的化合物进行晶体学研究将促进学生参与研究企业，并提高研究产品的频率和质量，包括学生合著的出版物和校外演示。通过进行内部结构测定程序，该仪器将为学生的发展和高级课程的准备以及进入研究生课程提供显着的促进。该仪器将通过向附近校园的研究人员提供晶体学支持来促进重要的外联和合作可能性，为正在进行的部门努力提供长期影响，以加强妇女，低收入/第一代大学生的招聘和保留，以及代表性不足的群体的成员，以追求化学科学的课程和职业生涯，该奖项旨在加强各级的研究和教育。它特别影响了结构变化对有机金属催化作用影响的研究。该仪器用于分析荧光团的构象和构型效应。此外，它还提供了关于亚苄基樟脑有机催化剂的信息。 该衍射仪还用于研究维生素K循环的机制。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Synthesis and optical properties of a library of multi-colored isomeric aryldibenzopyrylium halochromic cations

• DOI: 10.1016/j.tet.2020.131222
• 发表时间: 2020-06
• 期刊: Tetrahedron
• 影响因子: 2.1
• 作者: Samantha M. Meyer;Eva M. Charlesworth-Seiler;Joel G. Patrow;Jonathan P. Kitzrow;Deidra L. Gerlach;E. Reinheimer;B. J. Dahl

Crystal structure of 2-(2,2,6,6-tetramethylpiperidin-4-yl)-6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1 H -benz[de]isoquinoline-1,3(2 H)-dione

2-(2,2,6,6-四甲基哌啶-4-基)-6-[(2,2,6,6-四甲基哌啶-4-基)氨基]-1 H-苯并[去]异喹啉的晶体结构

• DOI: 10.1107/s2056989022010374
• 发表时间: 2022
• 期刊: Acta Crystallographica Section E Crystallographic Communications
• 作者: Pollock, Alicia A.;Huther, Holly A.;Birch, Cole M.;Reinheimer, Eric W.;Lewis, David E.;Gerlach, Deidra L.
• 通讯作者: Gerlach, Deidra L.