MRI: Acquisition of a Confocal Raman Microscope System for Nano-Bio-Chemical-Thermal Research

MRI：获取用于纳米生物化学热研究的共焦拉曼显微镜系统

• 批准号: 2018852
• 负责人: Gang Feng
• 金额: $ 52.33万
• 依托单位: Villanova University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018852&HistoricalAwards=false
• 关键词: MRI; Acquisition; Confocal; Raman; Microscope

Biological, chemical, and physical processes in industries such as healthcare, electronics, and energy production require controlled environments, sometimes with extreme conditions. For example, organ transplants need to be stored at ultralow temperatures. Fuel cells used for power generation often operate at very high temperatures, with specialized gases. The design of advanced materials and systems across many industries requires a better understanding of the biological and chemical processes involved. This demands testing environments that closely mimic real process conditions, which is an enormous challenge. The acquisition of a confocal Raman microscope with sophisticated environmental control will enable in vivo chemical mapping under a wide temperature range and different gas/liquid environments. This instrument will facilitate cutting-edge research and education projects across four research areas-nanomaterials, bioengineering, thermal and chemical engineering, and collaboration among three institutions-Villanova University, Bryn Mawr College, and Cabrini University. Moreover, the instrument will support a range of integrated research and education projects and provide opportunities for graduate and undergraduate students from diverse backgrounds. This facility will also be integrated into three K-12 outreach activities with an expected enrollment of over 500 under-represented students. With a temperature range of -196 to about 1000°C and controlled gas/liquid environments, the confocal Raman microscope can provide high resolution and real-time structural and chemical fingerprints of materials and chemicals. Raman spectroscopy has a unique compatibility with aqueous or high temperature, particularly suited for biological and high temperature characterizations. Seven projects will be enabled at three institutions. They include investigations on solid oxide fuel cells to provide important insight into fuel reaction mechanisms, two dimensional materials to promote new synthetic methods and understanding of their structure-property relations under extreme conditions, energy storage materials for high-performance energy storage systems, spin-phonon coupling in multiferroic oxides to provide unprecedented evidence for the mechanism of multiferroicity, molecular mechanisms of cryo-injury for developing cell preservation technologies, molecular properties of intact drosophila hearts to provide insights on physiological aging. By addressing all these needs, the proposed instrument will greatly advance knowledge and promote interdisciplinary research in nanomaterials, thermal and chemical engineering, and bioengineering/biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

医疗保健，电子和能源生产等行业中的生物，化学和物理过程需要受控环境，有时需要极端条件。例如，器官移植需要在超高温度下存储。用于发电的燃料电池通常在非常高的温度下运行，具有专门的气体。许多行业的先进材料和系统的设计需要更好地了解所涉及的生物学过程。这需要测试环境紧密模仿实际过程条件，这是一个增强的挑战。获得具有复杂环境控制的共焦拉曼显微镜的获取将使体内化学映射在较大的温度范围内和不同的气体/液体环境下。该工具将促进四个研究领域的纳米材料，生物工程，热和化学工程以及三个机构 - 维拉诺瓦大学，布莱恩·莫尔学院和卡布里尼大学之间的尖端研究和教育项目。此外，该工具将支持一系列综合研究和教育项目，并为来自潜水员背景的研究生和本科生提供机会。该设施还将集成到三项K-12外展活动中，预计有500多名代表不足的学生。与温度范围为-196至约1000°C和受控的气体/液体环境，共焦拉曼显微镜可以提供材料和化学物质的高分辨率和实时结构和化学指纹。拉曼光谱法具有与水性或高温的独特兼容性，特别适合生物学和高温特征。将在三个机构启用七个项目。它包括对固体氧化物燃料电池的研究，以提供对燃料反应机制的重要见解，二维材料，以促进新的合成方法及其在极端条件下的结构 - 核关系，用于高性能能量储能系统的能源储存材料，在多局部氧化物中旋转 - 量子偶联的多局部氧化物，以提供多种循环的crielderiistion croverients of Drespentiral coodentiral coodentive ofercentiral coodentiral ofercentiral机构，分别机制，分数机制，分数式机制，分别分类机制。技术，完整果蝇心脏的分子特性，可提供有关物理衰老的见解。通过满足所有这些需求，提出的工具将极大地促进知识并促进纳米材料，热和化学工程以及生物工程/生物学的跨学科研究。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的影响审查审查标准来通过评估来获得的支持。