权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

BII-Design: Integrating Biological Resilience Across Scales

BII-Design：跨尺度整合生物弹性

基本信息

批准号：
2021362
负责人：
Catherine Freudenreich
金额：
$ 20万
依托单位：
Tufts University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2021362&HistoricalAwards=false
关键词：
BII Design Integrating Biological Resilience

项目摘要

The concept of resilience - the ability of any system to return to a previous state after a perturbation – provides an ideal opportunity to unite different scales of biological research. The ever-increasing specialization of scientific research has made it challenging for researchers in different fields of biology to exchange ideas. The study of system resilience, however, is common to all biological fields of study. The overarching objective of this project is to use the theme of resilience to bridge cellular, organismal, and community-level scales of biology by synthesizing the tools, concepts, and approaches used by the different research fields. They will be integrated through 1) collaborative research that includes undergraduates, graduate students, postdocs, and faculty, 2) curricular enrichment, and 3) outreach to other institutions, non-profits, and industry. Conserved mechanisms of resilience identified through these activities will be applicable to engineer and manage biological systems in medical, agricultural, industrial, and natural contexts.This project will challenge scientists to span disciplinary, taxonomic, methodological, and other divides in biology to build and apply a unified framework for biological resilience. Many fields of biology have described resilience in their systems of study, but rarely are there integrative efforts to search for common patterns and processes of resilience across temporal and spatial scales. The first step of the project is to examine how existing models and metrics of resilience are implemented across biological scales. The second step is to determine if there are common mechanisms across scales that allow biological systems to maintain resilience. The final step will be to identify how the basic science of biological resilience can be used to design and manage cellular, organismal, and ecological systems. These areas of resilience will be examined through interdepartmental seminars in biological resilience, a regional symposium on biological resilience, a new graduate module on biological resilience, and graduate research fellowships in biological resilience. The investigators will carefully examine and refine the existing lexicon for biological resilience that can be widely adopted by other biologists and integrative biology research institutions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

恢复力的概念--任何系统在扰动后恢复到以前状态的能力--为联合不同规模的生物学研究提供了一个理想的机会。科学研究的日益专业化使得生物学不同领域的研究人员交流思想变得具有挑战性。然而，系统复原力的研究是所有生物学研究领域的共同之处。这个项目的首要目标是通过综合不同研究领域使用的工具、概念和方法，使用弹性这一主题来连接细胞、组织和社区级别的生物学。他们将通过1)包括本科生、研究生、博士后和教师在内的合作研究，2)丰富课程，以及3)向其他机构、非营利组织和行业拓展，将它们整合在一起。通过这些活动确定的保守的复原力机制将适用于医疗、农业、工业和自然环境中的生物系统的工程和管理。该项目将挑战科学家跨越生物学的学科、分类学、方法论和其他分歧，以建立和应用一个统一的生物复原力框架。生物学的许多领域都描述了其研究体系中的弹性，但很少有综合努力来寻找跨越时间和空间尺度的弹性的共同模式和过程。该项目的第一步是检查现有的复原力模型和衡量标准是如何在生物范围内实施的。第二步是确定是否存在跨尺度的共同机制，允许生物系统保持弹性。最后一步是确定如何利用生物复原力的基础科学来设计和管理细胞、生物和生态系统。这些复原力领域将通过生物复原力部门间研讨会、生物复原力区域专题讨论会、新的生物复原力研究生单元和生物复原力研究生研究金进行审查。研究人员将仔细检查和完善现有的可被其他生物学家和综合生物学研究机构广泛采用的生物弹性词汇。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。