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BII Design: Integrative Movement Sciences Institute (IMSI)

天地互连设计：综合运动科学研究所（IMSI）

基本信息

批准号：
2021832
负责人：
Monica Daley
金额：
$ 19.84万
依托单位：
University of California-Irvine
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2021832&HistoricalAwards=false
关键词：
BII Design Integrative Movement Sciences

项目摘要

Animals move with superb agility, achieving exceptional athletic feats of endurance, speed and rapid maneuvering through complex terrain. This requires precise coordination of muscle contraction, sensing and neural control in response to rapidly changing interactions with the physical environment. Modern science has revealed increasing detail about the molecular mechanisms, growth and function of discrete tissues and systems such as muscle, neurons and bone. Yet a pronounced gap exists in understanding how these systems work together to achieve agile whole-body movement. The Integrative Movement Sciences Institute (IMSI) will bring to together 26 faculty from 21 institutions, with collective expertise across the spectrum of movement sciences from molecular biophysics of muscle to human rehabilitation and human-machine interaction. IMSI will create a nationwide collaboration network and training pipeline from undergraduate to faculty levels, to transform our field by integrating understanding of muscle function and movement from molecules to behavior. IMSI will train the next generation of scientists in effective cross-disciplinary communication, team-based science, mathematical modeling, data analysis and open data sharing. Research activities will focus on development of integrated models of movement with a wide range of applications for human exercise sciences, rehabilitation, and mobility assistance, including the design and control of prostheses, exoskeletons, and biologically-inspired legged robots.A pronounced gap exists between ‘top-down’ approaches that focus on whole-animal behavior but lack insight into underlying mechanisms and ‘bottom-up’ approaches that identify molecular and biophysical mechanisms but lack insight into their contributions to behavior. Muscle forms a critical link in integrating mechanics and control of movement across scales. This project will fund communication, training and collaborative research development activities over 12-months to establish the Integrative Movement Sciences Institute (IMSI) at the University of California Irvine (UCI), with 26 faculty from 21 academic institutions. IMSI ‘Design’ activities include a workshop in Spring 2021 and a 4-week long Summer Research Institute in Summer 2021. Workshop activities will encourage thinking across disciplines and developing effective team-based collaborative approaches to overcome the challenges that currently inhibit integration across fields and organizational scales. The workshop will consolidate IMSI research themes and develop proposals for IMSI Summer Research Institute activities. The Summer Research Institute will be a 4-week event for enrolled trainees (undergraduates, graduate students and postdocs working in near-peer mentoring teams), with visiting PIs joining for one week to collaboratively lead seminars and short lab courses on topics designed to build interdisciplinary partnerships and integrate across scales. IMSI will focus on development of computationally tractable and predictive modeling tools for integrative neuromechanics of movement. These tools have potential to transform numerous fields— enabling neuroscientists, biologists, clinicians and biomedical engineers to ask questions about integrative whole organism behavior, sensorimotor control, musculoskeletal function and neuromuscular plasticity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

动物的行动非常敏捷，在复杂的地形中具有非凡的耐力、速度和快速机动能力。这需要精确协调肌肉收缩、感知和神经控制，以响应与物理环境快速变化的相互作用。现代科学已经揭示了越来越多的关于分子机制、生长和分立组织和系统（如肌肉、神经元和骨骼）功能的细节。然而，在理解这些系统如何协同工作以实现敏捷的全身运动方面存在明显的差距。综合运动科学研究所（IMSI）将汇集来自21个机构的26名教师，他们拥有从肌肉分子生物物理学到人类康复和人机交互等运动科学领域的集体专业知识。IMSI将建立一个全国性的合作网络和培训渠道，从本科生到教师水平，通过整合对肌肉功能和运动的理解，从分子到行为，来改变我们的领域。IMSI将在有效的跨学科沟通、团队科学、数学建模、数据分析和开放数据共享方面培养下一代科学家。研究活动将集中于开发具有广泛应用于人类运动科学、康复和行动辅助的综合运动模型，包括假肢、外骨骼和生物启发的有腿机器人的设计和控制。“自上而下”的方法关注整个动物的行为，但缺乏对潜在机制的洞察，而“自下而上”的方法识别分子和生物物理机制，但缺乏对行为贡献的洞察，两者之间存在明显的差距。肌肉在整合力学和跨尺度运动控制方面是一个关键环节。该项目将资助为期12个月的交流、培训和合作研究发展活动，在加州大学欧文分校（UCI）建立综合运动科学研究所（IMSI），由来自21个学术机构的26名教师组成。IMSI的“设计”活动包括2021年春季的研讨会和2021年夏季为期4周的暑期研究所。研讨会活动将鼓励跨学科思考和开发有效的基于团队的协作方法，以克服目前阻碍跨领域和组织规模整合的挑战。讲习班将巩固IMSI的研究主题，并为IMSI暑期研究所的活动提出建议。夏季研究所将是一个为期4周的活动，招收学员（本科生、研究生和博士后在近同伴指导团队中工作），访问pi加入一周，共同领导研讨会和短期实验课程，旨在建立跨学科的合作伙伴关系和跨规模整合。IMSI将专注于为运动的综合神经力学开发计算易于处理和预测的建模工具。这些工具有可能改变许多领域——使神经科学家、生物学家、临床医生和生物医学工程师能够提出有关整体有机体行为、感觉运动控制、肌肉骨骼功能和神经肌肉可塑性的问题。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。