Function and redundancy of SOX genes in the mammalian sex determination pathway

SOX基因在哺乳动物性别决定途径中的功能和冗余

• 批准号: DP0881509
• 负责人: Prof Paul Thomas
• 金额: $ 23.95万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0881509
• 关键词: Function; redundancy; SOX; genes; mammalian

We are studying a mouse model of abnormal sex organ development in which genetically female mice develop as males. Our basic research program will lead to greater understanding of the genetic switch controlling the formation of male and female characteristics. This research should in turn provide insight into the causes of defects in patients with disorders of sex development, helping to inform the difficult clinical decisions that need to be made for their treatment, and ultimately leading to better management and therapeutic strategies. Our studies may also provide unique methods to control the exotic mouse population, using the daughterless strategy.

我们正在研究一种性器官发育异常的小鼠模型，在这种模型中，遗传上雌性小鼠发育为雄性小鼠。我们的基础研究计划将导致对控制男性和女性特征形成的遗传开关的更深入了解。这项研究应该反过来提供深入了解性发育障碍患者缺陷的原因，帮助告知需要为他们的治疗做出困难的临床决策，并最终导致更好的管理和治疗策略。 我们的研究也可能提供独特的方法来控制外来小鼠种群，使用无女儿的策略。