Development of genetic technology for rodent population suppression

抑制啮齿动物种群的遗传技术的发展

• 批准号: LP180100748
• 负责人: Prof Paul Thomas
• 金额: $ 34.82万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-06-29 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP180100748
• 关键词: Development; genetic; technology; rodent; population

Vertebrate pests cost Australia over $1 billion each year in agricultural losses and environmental damage and novel strategies are urgently required to tackle this massive challenge. Newly proposed “gene drives”, which might rapidly spread through populations, have enormous potential for the sustained management and even eradication of pests. Through innovative application of cutting-edge genome editing approaches, this proposal aims to develop gene drive technology in mice as a prototypical vertebrate pest species. We will also develop cutting-edge mathematical models of rodent gene drives to identify crucial parameters for efficacious employment and investigate potential for impact on non-target populations.

脊椎动物害虫每年给澳大利亚造成超过10亿美元的农业损失和环境破坏，迫切需要新的战略来应对这一巨大挑战。新提出的“基因驱动”可能在种群中迅速传播，在持续管理甚至根除害虫方面具有巨大的潜力。通过创新应用尖端基因组编辑方法，这项提议旨在开发小鼠的基因驱动技术，将其作为典型的脊椎动物害虫物种。我们还将开发啮齿动物基因驱动的尖端数学模型，以确定有效就业的关键参数，并调查对非目标人群的潜在影响。