Genetic control of spermatogenesis: defining the role of SOX3 in spermatogonial progenitor cells
Genetic control of spermatogenesis: defining the role of SOX3 in spermatogonial progenitor cells
批准号:
DP140103965
负责人:
Prof Paul Thomas
金额:
$27.25万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31
中文摘要
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英文摘要
The transcription factor (TF) SOX3 is a key regulator of neural stem/progenitor cells. Recently, this project has also shown that SOX3 is active in sperm progenitors (spermatogonia) and is required for spermatogenesis. Using our Sox3 KO mouse model and extensive expertise in spermatogonial cell culture, ChIP-seq technology and bioinformatics, this project will investigate crucial aspects of SOX3 function in the testes including stem versus progenitor cell activity and genome-wide target gene regulation. These studies will uncover the molecular and cellular mechanism by which SOX3 controls spermatogenesis and provide unique insight into how a single TF controls context-dependent differentiation in sperm versus brain progenitor cells.
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