Development of efficient CRISPR gene drives in mice

在小鼠中开发高效的 CRISPR 基因驱动器

• 批准号: DP190102312
• 负责人: Prof Paul Thomas
• 金额: $ 29.16万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-26 至 2023-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102312
• 关键词: Development; efficient; CRISPR; gene; drives

This project aims to generate new tools for vertebrate pest management through development of cutting-edge gene drive technology in mice. Vertebrate pests cost Australia over $1 billion each year in agricultural losses and environmental damage and novel strategies are required to tackle this challenge. Newly developed “gene drives”, which can rapidly spread through populations, have enormous potential for the sustained management and even eradication of pests. This project aims to develop gene drive technology in mice as a prototypical vertebrate pest species. The project will potentially deliver valuable tools that directly impact Australia’s Science and Research Priority on Food.

该项目旨在通过在小鼠中开发尖端基因驱动技术来产生脊椎动物害虫管理的新工具。脊椎动物害虫每年给澳大利亚造成的农业损失和环境破坏超过10亿美元，需要采取新的战略来应对这一挑战。新开发的“基因驱动器”可在种群中迅速传播，具有可持续管理甚至根除害虫的巨大潜力。该项目旨在开发小鼠作为典型脊椎动物害虫物种的基因驱动技术。该项目将提供有价值的工具，直接影响澳大利亚的食品科学和研究优先事项。