CAREER: Transforming Multi-parametric Photoacoustic Microscopy

该项目旨在将显微镜从目前的低速台式系统转变为第一种高速微型/便携式设备，使可穿戴，手持应用成为可能。显微镜将包括许多目前可用的单独的光学模态到一个单一的多参数系统。拟议的系统将保留这些模式，而不会降低性能，但具有更好的可移植性，缩小尺寸，提高功能成像能力的数据收集效率。这一突破有望在神经科学、癌症临床治疗、心血管药物个性化筛查和伤口愈合管理等领域得到广泛应用。本项目所开发的技术将大大扩展多参数PAM在麻醉约束动物基础研究之外的应用范围。拟议的研究涉及光学和机械设计，数值模拟，微加工，数据处理，仪器开发和测试的多学科性质将为所有参与者提供均衡的培训机会。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This project aims to transform microscopy from the current low-speed benchtop system into the first-of-a-kind high-speed miniature/portable device that will enable wearable, handheld applications. The microscope will include many of the currently available separate optical modalities into a single multi-parameter system. The proposed system will retain these modalities with no reduction in performance yet with improved portability, reduction in size, and increased data collection efficiency for functional imaging capabilities. This breakthrough is expected to find broad applications in areas spanning from neuroscience to clinical treatment of cancer, personalized screening of cardiovascular drugs, and management of wound healing. The technology developed in this program will significantly expand the scope of multi-parametric PAM beyond basic research in anesthetized of restrained animals. The multidisciplinary nature of the proposed research involving optical and mechanical design, numerical simulation, microfabrication, data processing, instrument development and testing will offer well-balanced training opportunities for all participants.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.