I-Corps: Interferometric Imaging for Multiplexed Molecular Kinetics

这个I-Corps项目更广泛的影响/商业潜力是探索传感器的翻译，以获得更好的诊断和治疗。所提出的技术可以以低成本创建，使仪器，集成并行传感器的高通量system.This I-Corps项目探索的干涉反射成像传感器（IRIS），无标签检测（LFD）系统的应用。所提出的系统使用光学生物传感器在基于Si的微流控芯片作为低成本消耗品的分子结合动力学的多路成像检测。数百个捕获探针可以排列在IRIS芯片上，并针对目标分子进行并行测试。拟议的系统解决了多路复用和强大的小分子亲和力测量的需求，这可以使新的配体的检测和监测的小分子的紧凑sensors.This奖项的发现反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

The broader impact/commercial potential of this I-Corps project is to explore translation of a sensor for better diagnostics and therapeutics. The proposed technology can be created at low cost, enabling an instrument that integrates parallel sensors for a high-throughput system.This I-Corps project explores applications for the Interferometric Reflectance Imaging Sensor (IRIS), a label-free detection (LFD) system. The proposed system uses optical biosensors in multiplexed imaging detection of molecular binding kinetics on Si-based microfluidic chips as low-cost consumables. Hundreds of capture probes can be arrayed on the IRIS chip and tested against a target molecule in parallel. The proposed system addresses needs for multiplexed and robust small molecule affinity measurements, which can enable the discovery of new ligands for detection and monitoring of small molecules for compact sensors.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.