RAPID: COVID Response: Identifying practices that minimize exposure to disinfection byproducts

快速:新冠病毒应对:确定尽量减少接触消毒副产物的做法

基本信息

  • 批准号:
    2027420
  • 负责人:
  • 金额:
    $ 19.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-05-01 至 2021-04-30
  • 项目状态:
    已结题

项目摘要

To curb the spread of COVID-19, communities across the world are disinfecting buildings and other public places. Cleaning workers wear different levels of personal protection ranging from simple surgical masks to professional high efficiency filtration masks. Depending on the mask type, cleaning process, surfaces, and disinfectants used, cleaning workers can be exposed to disinfection byproducts that form as a result of reactions between disinfectants, the surfaces being cleaned, and the mask materials. This project will quantify inhalation of disinfection byproducts during disinfection while wearing different classes of masks and use this information to make recommendations on which mask to wear and how often to change or clean the mask or mask components. These data are directly relevant to the current worldwide COVID-19 crisis and similar future pandemic challenges. The core project team includes at least three graduate research assistants, one postdoctoral scholar, and five professors with different backgrounds and at different stages of their careers. Thus, a further impact of this project will be advancing education and training the next generation of scientists and engineers in techniques to respond to pandemic challenges. This project consists of a two-phase approach to address potential health threats to cleaning workers resulting from the large-scale use of disinfection in response to the global COVID-19 pandemic. The goal of the first phase is to define possible concentration ranges of chemicals that flow through personal protection masks based on: 1) the type of disinfectant used; 2) the application process (e.g. wiping, spraying, or fogging); 3) chemical processes forming byproducts (such as reaction of cleaning products on surfaces); 4) environmental conditions (such as ventilation/dilution rate); and 5) proximity of the cleaning worker to the chemical source. The goal of phase two is to characterize the inhalation of disinfection byproducts. A full-scale thermal manikin equipped with a nose and mouth breathing simulation system will be exposed to uniform concentrations of byproducts determined in phase one in an environmental chamber. Surface chemical reaction processes and kinetics will be studied with different masks and byproduct inhalation will be assessed via mass spectrometry. The manikin will be equipped with four different classes of masks: surgical mask, dust mask without exhalation relief valve, dust mask with exhalation relief valve, and professional mask. It is likely that some masks decrease inhalation exposure to disinfection byproducts while others increase exposure via adsorption of cleaning product vapors to the mask and by addition of moisture due to exhalation. These processes lead to a mask chemistry that produces additional chemical products whose concentration is much greater in the mask than in the ambient air. These secondary products are potentially more harmful than the primary vapors of cleaning products. Successful completion of this study will provide timely and critical data relevant to the current crisis by identifying risks for different types of masks and cleaning products. Such information will inform recommendations on mask use to protect the health of cleaning workers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
为了遏制 COVID-19 的传播,世界各地的社区正在对建筑物和其他公共场所进行消毒。清洁工人佩戴不同级别的个人防护,从简单的外科口罩到专业的高效过滤口罩。根据口罩类型、清洁过程、表面和使用的消毒剂,清洁工人可能会接触到消毒剂、被清洁表面和口罩材料之间反应形成的消毒副产物。该项目将量化佩戴不同类别口罩时消毒过程中吸入的消毒副产物,并利用这些信息就佩戴哪种口罩以及更换或清洁口罩或口罩组件的频率提出建议。这些数据与当前全球范围内的 COVID-19 危机和未来类似的流行病挑战直接相关。核心项目团队包括至少三名研究生研究助理、一名博士后学者和五名不同背景、不同职业阶段的教授。因此,该项目的进一步影响将是促进教育和培训下一代科学家和工程师应对流行病挑战的技术。该项目包括一个两阶段的方法,旨在解决因应对全球 COVID-19 大流行而大规模使用消毒措施对清洁工人造成的潜在健康威胁。第一阶段的目标是根据以下因素确定流经个人防护口罩的化学物质的可能浓度范围:1) 使用的消毒剂类型; 2) 应用过程(例如擦拭、喷涂或雾化); 3)化学过程形成副产品(例如清洁产品在表面上的反应); 4)环境条件(如通风/稀释率); 5) 清洁工人距离化学品源的距离。第二阶段的目标是表征消毒副产物的吸入。配备鼻子和嘴巴呼吸模拟系统的全尺寸热模型将暴露在环境室中第一阶段确定的均匀浓度的副产品中。将使用不同的面罩研究表面化学反应过程和动力学,并通过质谱法评估副产物的吸入。该模型将配备四种不同类别的口罩:外科口罩、不带呼气安全阀的防尘口罩、带呼气安全阀的防尘口罩和专业口罩。一些口罩可能会减少消毒副产品的吸入暴露,而另一些口罩可能会通过将清洁产品蒸汽吸附到口罩上以及因呼气而增加水分来增加接触消毒副产品的机会。这些过程导致面罩化学物质产生额外的化学产品,其浓度在面罩中比在环境空气中高得多。这些次级产品可能比清洁产品的主要蒸气更有害。这项研究的成功完成将通过识别不同类型口罩和清洁产品的风险,提供与当前危机相关的及时和关键数据。此类信息将为有关使用口罩的建议提供信息,以保护清洁工人的健康。该奖项反映了 NSF 的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Emissions from Hydrogen Peroxide Disinfection and Their Interaction with Mask Surfaces
  • DOI:
    10.1021/acsengineeringau.3c00036
  • 发表时间:
    2024-01-09
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Abue,Pearl;Bhattacharyya,Nirvan;Ruiz,Lea Hildebrandt
  • 通讯作者:
    Ruiz,Lea Hildebrandt
Volatile organic compound (VOC) emissions from the usage of benzalkonium chloride and other disinfectants based on quaternary ammonium compounds
使用苯扎氯铵和其他季铵化合物消毒剂产生的挥发性有机化合物 (VOC) 排放
  • DOI:
    10.1039/d2ea00054g
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jahn, Leif G.;Tang, Mengjia;Blomdahl, Daniel;Bhattacharyya, Nirvan;Abue, Pearl;Novoselac, Atila;Ruiz, Lea Hildebrandt;Misztal, Pawel K.
  • 通讯作者:
    Misztal, Pawel K.
Bleach Emissions Interact Substantially with Surgical and KN95 Mask Surfaces
漂白剂排放物与手术口罩和 KN95 口罩表面发生显着相互作用
  • DOI:
    10.1021/acs.est.2c07937
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    11.4
  • 作者:
    Bhattacharyya, Nirvan;Tang, Mengjia;Blomdahl, Daniel C.;Jahn, Leif G.;Abue, Pearl;Allen, David T.;Corsi, Richard L.;Novoselac, Atila;Misztal, Pawel K.;Hildebrandt Ruiz, Lea
  • 通讯作者:
    Hildebrandt Ruiz, Lea
Influence of Application Method on Disinfectant Byproduct Formation during Indoor Bleach Cleaning: A Case Study on Phenol Chlorination
  • DOI:
    10.1021/acsestair.3c00011
  • 发表时间:
    2023-11
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Leif G. Jahn;Nirvan Bhattacharyya;Daniel C. Blomdahl;Mengjia Tang;Pearl Abue;A. Novoselac;Lea Hildebrandt Ruiz;P. Misztal
  • 通讯作者:
    Leif G. Jahn;Nirvan Bhattacharyya;Daniel C. Blomdahl;Mengjia Tang;Pearl Abue;A. Novoselac;Lea Hildebrandt Ruiz;P. Misztal
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Lea Hildebrandt Ruiz其他文献

Interactive comment on “ Secondary organic aerosol from chlorine-initiated oxidation of isoprene ” by Dongyu S
董宇S对《异戊二烯氯引发氧化产生的二次有机气溶胶》的互动评论
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Lea Hildebrandt Ruiz;Dongyu S. Wang
  • 通讯作者:
    Dongyu S. Wang
Air pollution from unconventional oil and gas development in the Eagle Ford Shale
  • DOI:
    10.1016/j.atmosenv.2024.120812
  • 发表时间:
    2024-12-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kristi N. McPherson;Leif G. Jahn;Catherine G. Masoud;Nirvan Bhattacharyya;Mrinali Modi;Kanan Patel;Pearl Abue;Daniel Blomdahl;Pawel K. Misztal;Lea Hildebrandt Ruiz
  • 通讯作者:
    Lea Hildebrandt Ruiz

Lea Hildebrandt Ruiz的其他文献

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{{ truncateString('Lea Hildebrandt Ruiz', 18)}}的其他基金

Collaborative Research: A Halogen Oxidant Flow Reactor: Development and Use in Laboratory and Field Studies
合作研究:卤素氧化剂流动反应器:实验室和现场研究的开发和使用
  • 批准号:
    1934369
  • 财政年份:
    2019
  • 资助金额:
    $ 19.03万
  • 项目类别:
    Continuing Grant
Collaborative Research: ICARUS - Index of Chamber Atmospheric Research in the United States
合作研究:ICARUS - 美国室内大气研究索引
  • 批准号:
    1740587
  • 财政年份:
    2017
  • 资助金额:
    $ 19.03万
  • 项目类别:
    Standard Grant
CAREER: Air-Quality Effects of Atmospheric Chlorine Chemistry
职业:大气氯化学对空气质量的影响
  • 批准号:
    1653625
  • 财政年份:
    2017
  • 资助金额:
    $ 19.03万
  • 项目类别:
    Continuing Grant
AGS-PRF: Understanding the Early Growth of Atmospheric Nanoparticles
AGS-PRF:了解大气纳米粒子的早期生长
  • 批准号:
    1137757
  • 财政年份:
    2011
  • 资助金额:
    $ 19.03万
  • 项目类别:
    Fellowship Award

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