RAPID: Understanding the Transmission and Prevention of COVID-19 with Biomedical Knowledge Engineering

点击翻译按钮获取中文摘要

COVID-19 has been a global pandemic affecting millions of people across hundreds of countries. Great efforts have been devoted to the research on the understanding of the transmission and prevention of COVID-19. Staying up-to-date with the latest research is crucial to the researchers and practitioners. However, the rapid growing of the number of the relevant literature makes this a challenging task. This project proposes to build a COVID 19 specific knowledge graph to facilitate the acquisition of COVID-19 related knowledge. The knowledge graph will also be continuously updated with the information extracted from latest biomedical literature with natural language processing techniques. A software pipeline that integrates and makes the knowledge graph publicly available as a web service with user friendly interface supporting information retrieval and question answering. Interactive visualization will be provided for the users to explore the knowledge graph and derive the inference paths to obtain the answers. All associated data and source codes for constructing the knowledge graph will be made publicly available. This project constructs a COVID-19 specific knowledge graph by 1) integrating the existing knowledge bases on biomedical entities from biological, clinical and epidemiological scales; 2) extracting new knowledge from latest biomedical literature and enhancing the constructed knowledge graph continuously. Although the knowledge graph targets COVID-19, the developed pipeline and techniques can be easily extended to other critical diseases as well. The technical content of the proposed research will impact public health, biomedical informatics, computer science and epidemiology. The results of the proposed research will be incorporated into the classes. Females and underrepresented researchers, undergraduates and K-12 students, will be actively engaged in the research effort of this project.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.