Dimensions US-China: Collaborative Research: Impacts of heritable plant-fungus symbiosis on phylogenetic, genetic and functional diversity
维度 中美:合作研究:可遗传植物-真菌共生对系统发育、遗传和功能多样性的影响
基本信息
- 批准号:2030060
- 负责人:
- 金额:$ 42.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-01 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
As primary producers of life, the hundreds of thousands of species of flowering plants are an essential component of Earth’s biodiversity. Interestingly, seeds of flowering plants often bear additional biological diversity in the form of partnering fungi and bacteria. Diverse impacts of seed-borne fungi include enhanced protection of host plants from parasites, pathogens and drought, as well as effects on diversity of their ecosystems. Recently, one fungus was even shown to donate a disease resistance gene to a wild relative of wheat. This study employs cutting-edge methods in ecology, genomics and other biological sciences to research the diversity of plants and their seed-borne fungal partners in the U.S. and in China, a global hotspot for plant diversity. Results will guide efforts to preserve biological diversity and promote healthy, resilient and productive natural ecosystems, rangelands and pastures. Outputs to the public and the scientific community will enhance knowledge of plant-microbe symbiosis as a key dimension of diversity. The research and educational exchange activities will strengthen and diversify scientific collaboration between scientists and students in China and the U.S., provide training to graduate students and postdocs in a broad range of biological and bioinformatic sciences, and integrate field, classroom, and lab activities for K-12 and undergraduate students to discover microscopic and macroscopic layers of biological complexity.This project will first entail a survey for seed-borne fungal endophytes across the taxonomic range of flowering plants, with emphasis on the plant diversity in China. The GBOWS (Germplasm Bank of Wild Species) seed collection in Kunming, China encompasses 37% of Chinese flowering plant species, and this and other collections will be surveyed to examine occurrence and possible roles of fungal seed-endophytes in the diversity of flowering plants. Then, endophyte-symbiotic plant species will be surveyed over wide geographic ranges to elucidate interactions of different “dimensions” of diversity of the target plants and their symbionts. Such dimensions will include genetics, gene expression, morphological characteristics, and ecological effects. These studies will also extend to neighboring plants that grow in association with the target species and the seed-endophytes that they, too, might possess. To complement these broad-scale surveys, the third objective will involve field experiments, conducted jointly with K-12 schools, to test how seed-borne fungal endophytes of grasses and legumes may drive diversity of their hosts and the broader plant community.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
作为生命的主要生产者,数十万种开花植物是地球生物多样性的重要组成部分。有趣的是,开花植物的种子通常以真菌和细菌的形式携带额外的生物多样性。种子携带真菌的各种影响包括加强保护宿主植物免受寄生虫,病原体和干旱的影响,以及对其生态系统多样性的影响。最近,一种真菌甚至被证明可以将抗病基因捐赠给小麦的野生亲戚。这项研究采用生态学,基因组学和其他生物科学的尖端方法,研究美国和中国植物及其种子携带真菌伙伴的多样性,这是全球植物多样性的热点。成果将指导保护生物多样性和促进健康、有复原力和多产的自然生态系统、牧场和牧场的努力。向公众和科学界提供的产出将增进对植物-微生物共生作为多样性的一个关键方面的了解。研究和教育交流活动将加强中美两国科学家和学生之间的科学合作,为研究生和博士后提供广泛的生物和生物信息科学方面的培训,并为K-12和本科生提供现场,课堂和实验室活动,以发现生物复杂性的微观和宏观层面。该项目将首先进行开花植物分类范围内的种子携带真菌内生菌调查,重点是中国的植物多样性。中国昆明的GBOWS(野生物种种质库)种子库包含37%的中国开花植物物种,将对该种子库和其他种子库进行调查,以研究真菌种子内生菌在开花植物多样性中的发生和可能作用。然后,内生共生植物物种将在广泛的地理范围内进行调查,以阐明目标植物及其共生体的多样性的不同“维度”的相互作用。这些方面包括遗传学、基因表达、形态特征和生态效应。这些研究还将扩展到与目标物种和它们可能拥有的种子内生菌相关的邻近植物。为了补充这些大规模的调查,第三个目标将涉及与K-12学校联合进行的实地实验,以测试禾本科和豆科植物种子携带的真菌内生菌如何驱动其宿主和更广泛的植物群落的多样性。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hydrology shapes microbial communities and microbiome‐mediated growth of an Everglades tree island species
水文学塑造微生物群落和微生物组——介导大沼泽地树岛物种的生长
- DOI:10.1111/rec.13677
- 发表时间:2022
- 期刊:
- 影响因子:3.2
- 作者:Almeida, Brianna K.;Cline, Eric;Sklar, Fred;Afkhami, Michelle E.
- 通讯作者:Afkhami, Michelle E.
Multidimensional specialization and generalization are pervasive in soil prokaryotes
- DOI:10.1038/s41559-023-02149-y
- 发表时间:2023-08
- 期刊:
- 影响因子:16.8
- 作者:Damian J. Hernandez;K. Kiesewetter;Brianna K. Almeida;Daniel Revillini;Michelle E. Afkhami
- 通讯作者:Damian J. Hernandez;K. Kiesewetter;Brianna K. Almeida;Daniel Revillini;Michelle E. Afkhami
Fragmentation disrupts microbial effects on native plant community productivity
- DOI:10.1111/1365-2745.14097
- 发表时间:2023-03
- 期刊:
- 影响因子:5.5
- 作者:K. Kiesewetter;Leydiana Otano;Michelle E. Afkhami
- 通讯作者:K. Kiesewetter;Leydiana Otano;Michelle E. Afkhami
Salinity legacy: Foliar microbiome's history affects mutualist‐conferred salinity tolerance
盐度遗产:叶面微生物组的历史影响互利共生,赋予盐度耐受性
- DOI:10.1002/ecy.3679
- 发表时间:2022
- 期刊:
- 影响因子:4.8
- 作者:Subedi, Suresh C.;Allen, Preston;Vidales, Rosario;Sternberg, Leonel;Ross, Michael;Afkhami, Michelle E.
- 通讯作者:Afkhami, Michelle E.
Multiple Mutualism Effects generate synergistic selection and strengthen fitness alignment in the interaction between legumes, rhizobia and mycorrhizal fungi
- DOI:10.1111/ele.13814
- 发表时间:2021-06-10
- 期刊:
- 影响因子:8.8
- 作者:Afkhami, Michelle E.;Friesen, Maren L.;Stinchcombe, John R.
- 通讯作者:Stinchcombe, John R.
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Michelle Afkhami其他文献
Novel Salvage Therapies Are Highly Effective in Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) with Philadelphia (Ph)-like Fusions
- DOI:
10.1182/blood-2022-158288 - 发表时间:
2022-11-15 - 期刊:
- 影响因子:
- 作者:
Ibrahim Aldoss;Dongyun Yang;Michelle Afkhami;Zhaohui Gu;Sally Mokhtari;Shilpa Shahani;Vaibhav Agrawal;Hoda Pourhassan;Paul B. Koller;Vanina Tomasian;Milhan Telatar;Monzr M. Al Malki;Amandeep Salhotra;Haris Ali;Ahmed Aribi;Karamjeet S. Sandhu;Shukaib Arslan;Brian J Ball;Salman Otoukesh;Idoroenyi Amanam - 通讯作者:
Idoroenyi Amanam
A Phase 1 Study of Venetoclax in Combination with a Pediatric-Inspired Regimen for the Treatment of Newly Diagnosed Adults with B-Cell Ph-like ALL
- DOI:
10.1182/blood-2023-187469 - 发表时间:
2023-11-02 - 期刊:
- 影响因子:
- 作者:
Ibrahim Aldoss;Jianying Zhang;Marjorie Robbins;Vaibhav Agrawal;Ahmed Aribi;Hoda Pourhassan;Paul B. Koller;Amanda Blackmon;Karamjeet S. Sandhu;Haris Ali;Brian J. Ball;Andrew Artz;Monzr M. Al Malki;Amandeep Salhotra;Zhaohui Gu;Asucena Leon Beltran;Christina Lai;Michelle Afkhami;Lucy Y. Ghoda;Stephen J. Forman - 通讯作者:
Stephen J. Forman
Mechanistic Insights into Reversal of Pulmonary Hypertension by Estrogen Therapy
- DOI:
10.1016/j.bpj.2010.12.2488 - 发表时间:
2011-02-02 - 期刊:
- 影响因子:
- 作者:
Soban Umar;Humann Matori;Andrea Iorga;Michelle Afkhami;Jingyuan Li;Federica Maltese;Mansoureh Eghbali - 通讯作者:
Mansoureh Eghbali
Phase 1b Study of IDH Inhibition with Enasidenib and MEK Inhibition with Cobimetinib in Patients with Relapsed or Refractory Acute Myeloid Leukemia Who Have Co-Occurring emIDH2/em and emRAS/em Signaling Gene Mutations
在同时存在 IDH2 突变和 RAS 突变信号通路基因突变的复发或难治性急性髓系白血病患者中,用恩西地平进行 IDH 抑制和用考比替尼进行 MEK 抑制的 1b 期研究
- DOI:
10.1182/blood-2024-211652 - 发表时间:
2024-11-05 - 期刊:
- 影响因子:23.100
- 作者:
Brian J. Ball;Jianying Zhang;Michelle Afkhami;Marjorie Robbins;Lauren Chang;Samantha Humpal;Vania Porras;Yilun Liu;Tim W Synold;Sarah Farzinkhou;Azra Borogovac;Paul B. Koller;Hoda Pourhassan;Vaibhav Agrawal;Anthony S. Stein;Mary-Elizabeth M. Percival;Alexey V. Danilov;Guido Marcucci - 通讯作者:
Guido Marcucci
Phase 1b Study of IDH Inhibition with Enasidenib and MEK Inhibition with Cobimetinib in Patients with Relapsed or Refractory Acute Myeloid Leukemia Who Have Co-Occurring <em>IDH2</em> and <em>RAS</em> Signaling Gene Mutations
- DOI:
10.1182/blood-2024-211652 - 发表时间:
2024-11-05 - 期刊:
- 影响因子:
- 作者:
Brian J. Ball;Jianying Zhang;Michelle Afkhami;Marjorie Robbins;Lauren Chang;Samantha Humpal;Vania Porras;Yilun Liu;Tim W Synold;Sarah Farzinkhou;Azra Borogovac;Paul B. Koller;Hoda Pourhassan;Vaibhav Agrawal;Anthony S. Stein;Mary-Elizabeth M. Percival;Alexey V. Danilov;Guido Marcucci - 通讯作者:
Guido Marcucci
Michelle Afkhami的其他文献
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{{ truncateString('Michelle Afkhami', 18)}}的其他基金
Microbial landscapes: Are microorganisms hidden drivers of species distributions?
微生物景观:微生物是物种分布的隐藏驱动力吗?
- 批准号:
1922521 - 财政年份:2019
- 资助金额:
$ 42.48万 - 项目类别:
Standard Grant
NSF NPGI Postdoctoral Fellowship in Biology FY 2014
2014 财年 NSF NPGI 生物学博士后奖学金
- 批准号:
1401840 - 财政年份:2014
- 资助金额:
$ 42.48万 - 项目类别:
Fellowship Award
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