Novel cysteine-rich conotoxin frameworks from Australian cone snails

来自澳大利亚锥螺的新型富含半胱氨酸的芋螺毒素框架

• 批准号: DP160101043
• 负责人: Em/Prof Paul Alewood
• 金额: $ 14.71万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-07-08
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160101043
• 关键词: Novel; cysteine; rich; conotoxin; frameworks

This project aims to discover conotoxins that are potential drug leads or useful pharmacological tools. It aims to increase both the discovery of novel conotoxin cysteine-rich frameworks through integrated transcriptomics and proteomics (venomics), conotoxin synthesis and 3-D structure determination, and to generate conotoxin disulfide bond mimetics and conotoxin dendrimers to increase stability, potency and selectivity. The work is designed to be based on a venomics platforms to accelerate conotoxin framework discovery while using novel mimetics and dendrimeric constructs to improve their biophysical properties. The expected outcomes include an expansion of novel conotoxin sequences and novel frameworks to generate lead molecules for potential development.

本项目旨在发现芋螺毒素作为潜在的药物先导或有用的药理学工具。其目的是通过整合转录组学和蛋白质组学（静脉组学）、芋螺毒素合成和3-D结构测定来增加新的富含半胱氨酸的芋螺毒素框架的发现，并产生芋螺毒素二硫键模拟物和芋螺毒素树枝状聚合物以增加稳定性、效力和选择性。这项工作旨在基于毒液组学平台来加速芋螺毒素框架的发现，同时使用新型模拟物和树枝状聚合物构建体来改善其生物物理特性。预期的成果包括扩大新的芋螺毒素序列和新的框架，以产生潜在的发展铅分子。