CHARACTERISATION OF NOVEL BIOACTIVES FROM AUSTRALIAN HONEY WITH THERAPEUTIC POTENTIAL

澳大利亚蜂蜜中具有治疗潜力的新型生物活性物质的表征

• 批准号: LP0348042
• 负责人: Em/Prof Paul Alewood
• 金额: $ 18.35万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-04-02 至 2006-04-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0348042
• 关键词: CHARACTERISATION; NOVEL; BIOACTIVES; AUSTRALIAN; HONEY

Honey from specific Australian flowering plants has been identified that contain significant therapeutic properties in wound healing and other treatments. The research project proposed will identify and fully characterise the bioactive components of selected Australian honey (Medihoney) with antibiotic and growth promoting activites. These aims will be supported by high resolution mass spectrometry interfaced with HPLC and or affinity chip surfaces, 750 MHz NMR analysis and a range of relevant bioassays on specific organisms and cell lines. These outcomes will not only enhance the value of current honey-based products but have the potential to identify new therapeutic lead molecules.

来自澳大利亚特定开花植物的蜂蜜已被鉴定出在伤口愈合和其他治疗中含有显著的治疗特性。拟议的研究项目将鉴定和充分描述精选的澳大利亚蜂蜜(麦迪蜜)的生物活性成分，具有抗菌和促进生长的活性。这些目标将得到与高效液相和/或亲和芯片表面连接的高分辨率质谱仪、750 MHz核磁共振分析以及对特定生物体和细胞系的一系列相关生物分析的支持。这些结果不仅将提高目前以蜂蜜为基础的产品的价值，而且有可能识别新的治疗用铅分子。