CAREER: Metabolomics-Enabled Approaches to Advance Characterization of Organic Matter Trapping in Natural and Engineered Matrices

职业:利用代谢组学方法推进天然和工程基质中有机物捕获的表征

基本信息

  • 批准号:
    2041669
  • 负责人:
  • 金额:
    $ 34.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-07-01 至 2023-04-30
  • 项目状态:
    已结题

项目摘要

1653092Aristilde The key objective of this project is to investigate the mechanisms underlying the trapping of organic contaminants at mineral surfaces. This trapping controls transformation and transport rates within lake and river sediments, soil subsurfaces, landfills, and water filtration systems. The overarching goal of the proposed research is to develop a new approach that combines experimental and computational methods to obtain insights at the molecular scale into the trapping of organic contaminants within complex organo-mineral mixtures. The research findings will advance a new theoretical framework for addressing solid waste treatment and long-term organic matter sequestration in lake and river environments.The PI will investigate organic matter structures at mineral surfaces that drive the trapping of organic contaminants. The research activities are built on the PI's expertise in surface spectroscopy, molecular biology, and computational simulations and will exploit recent advances in mass spectrometry and metabolomics for the molecular fingerprinting of biological systems. The PI will exploit a novel application of metabolomics as adopted from the field of molecular biology towards filling an important knowledge gap in environmental engineering processes: elucidating the supramolecular chemistry that governs the trapping of organic contaminants and natural organic matter within organo-mineral matrices. Limitations in this molecular depiction have prevented a comprehensive understanding of the mechanisms responsible for the sequestration of organic contaminants within natural and engineered soil environments. The research goals are to develop a transformative mechanistic understanding of: (1) the hierarchy of assembled biomolecules on mineral surfaces; (2) the evolution of the trapping of organic contaminants within organo-mineral complexes; and, (3) the supramolecular architecture of biomolecular assemblies encapsulating contaminants at mineral interfaces. The outreach activities will be aimed at increasing the public literacy of the molecular-scale and nanoscale processes that drive the fate of organic matter and organic contaminants with relevance to public and ecosystem health. This task will be achieved through the implementation of a newly-designed program entitled ScENE VI: Scientific Explorations of the Natural Environment from the Visible to the Invisible. This program will be integrated with established partnerships with the local hands-on science museum Sciencenter, the Cornell cooperative extension office in New York City, the Cornell Occupational and Environmental Health, and the New York Department of Conservation. The activities through ScENE VI aim to provide interactive activities for young museum visitors and underrepresented teens of NYC 4-H youth development program.
1653092 Aristilde该项目的主要目标是研究矿物表面捕获有机污染物的机制。这种捕获控制湖泊和河流沉积物、土壤次表层、垃圾填埋场和水过滤系统内的转化和运输速率。拟议的研究的总体目标是开发一种新的方法,结合实验和计算方法,以获得在分子尺度上捕获复杂的有机矿物混合物中的有机污染物的见解。该研究成果将为解决固体废物处理和湖泊和河流环境中长期有机物封存问题提出一个新的理论框架。PI将研究矿物表面的有机物结构,这些结构驱动有机污染物的捕获。 研究活动建立在PI在表面光谱学,分子生物学和计算模拟方面的专业知识基础上,并将利用质谱和代谢组学的最新进展进行生物系统的分子指纹分析。 PI将利用代谢组学的新应用,从分子生物学领域填补环境工程过程中的一个重要知识空白:阐明超分子化学,控制有机污染物和天然有机物在有机无机基质中的捕获。这种分子描述的局限性阻碍了对自然和工程土壤环境中有机污染物螯合机制的全面理解。研究目标是发展一种变革性的机械理解:(1)矿物表面组装生物分子的层次结构;(2)有机-矿物复合物中有机污染物捕获的演变;以及(3)矿物界面生物分子组装包封污染物的超分子结构。外联活动的目的是提高公众对影响有机物质和有机污染物命运的分子级和纳米级过程的认识,这些过程与公众和生态系统健康有关。这一任务将通过实施一项新设计的方案来完成,该方案题为ScENE VI:对自然环境进行从可见到不可见的科学探索。该计划将与当地动手科学博物馆Sciencenter,康奈尔合作推广办公室在纽约市,康奈尔职业和环境健康,和纽约保护部建立合作伙伴关系。通过ScENE VI的活动旨在为年轻的博物馆游客和纽约市4-H青年发展计划的代表性不足的青少年提供互动活动。

项目成果

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Ludmilla Aristilde其他文献

Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists
跨尺度解构合成生物学:一种培训合成生物学家的概念方法
  • DOI:
    10.1038/s41467-024-49626-x
  • 发表时间:
    2024-06-26
  • 期刊:
  • 影响因子:
    15.700
  • 作者:
    Ashty S. Karim;Dylan M. Brown;Chloé M. Archuleta;Sharisse Grannan;Ludmilla Aristilde;Yogesh Goyal;Josh N. Leonard;Niall M. Mangan;Arthur Prindle;Gabriel J. Rocklin;Keith J. Tyo;Laurie Zoloth;Michael C. Jewett;Susanna Calkins;Neha P. Kamat;Danielle Tullman-Ercek;Julius B. Lucks
  • 通讯作者:
    Julius B. Lucks
An integrated systems biology approach reveals differences in formate metabolism in the genus emMethanothermobacter/em
一种综合系统生物学方法揭示了甲烷八叠球菌属中甲酸代谢的差异
  • DOI:
    10.1016/j.isci.2023.108016
  • 发表时间:
    2023-10-20
  • 期刊:
  • 影响因子:
    4.100
  • 作者:
    Isabella Casini;Tim McCubbin;Sofia Esquivel-Elizondo;Guillermo G. Luque;Daria Evseeva;Christian Fink;Sebastian Beblawy;Nicholas D. Youngblut;Ludmilla Aristilde;Daniel H. Huson;Andreas Dräger;Ruth E. Ley;Esteban Marcellin;Largus T. Angenent;Bastian Molitor
  • 通讯作者:
    Bastian Molitor
Unraveling iron oxides as abiotic catalysts of organic phosphorus recycling in soil and sediment matrices
揭示氧化铁作为土壤和沉积物基质中有机磷循环的非生物催化剂
  • DOI:
    10.1038/s41467-024-47931-z
  • 发表时间:
    2024-07-18
  • 期刊:
  • 影响因子:
    15.700
  • 作者:
    Jade J. Basinski;Sharon E. Bone;Annaleise R. Klein;Wiriya Thongsomboon;Valerie Mitchell;John T. Shukle;Gregory K. Druschel;Aaron Thompson;Ludmilla Aristilde
  • 通讯作者:
    Ludmilla Aristilde
Toward industrial C8 production: oxygen intrusion drives renewable emn/em-caprylate production from ethanol and acetate emvia/em intermediate metabolite production
迈向工业 C8 生产:氧气侵入推动乙醇和乙酸盐经由中间代谢物生产可再生的月桂酸酯
  • DOI:
    10.1039/d5gc00411j
  • 发表时间:
    2024-12-06
  • 期刊:
  • 影响因子:
    9.200
  • 作者:
    Kurt Gemeinhardt;Byoung Seung Jeon;Jean Nepomuscene Ntihuga;Han Wang;Caroline Schlaiß;Timo N. Lucas;Irina Bessarab;Nicolas Nalpas;Nanqing Zhou;Joseph G. Usack;Daniel H. Huson;Rohan B. H. Williams;Boris Maček;Ludmilla Aristilde;Largus T. Angenent
  • 通讯作者:
    Largus T. Angenent

Ludmilla Aristilde的其他文献

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{{ truncateString('Ludmilla Aristilde', 18)}}的其他基金

CAS-MNP: Molecular Probing Surface Reactivity Dynamics of Native versus Photo-Oxidized Microplastics and Nanoplastics in Environmental Aqueous Media
CAS-MNP:环境水介质中天然与光氧化微塑料和纳米塑料的分子探测表面反应动力学
  • 批准号:
    2109097
  • 财政年份:
    2021
  • 资助金额:
    $ 34.75万
  • 项目类别:
    Standard Grant
Elucidating and Computing Metabolic Networks for Co-Valorization of Cellulose and Lignin Derivatives
阐明和计算纤维素和木质素衍生物共同增值的代谢网络
  • 批准号:
    2022854
  • 财政年份:
    2020
  • 资助金额:
    $ 34.75万
  • 项目类别:
    Standard Grant
CAREER: Metabolomics-Enabled Approaches to Advance Characterization of Organic Matter Trapping in Natural and Engineered Matrices
职业:利用代谢组学方法推进天然和工程基质中有机物捕获的表征
  • 批准号:
    1653092
  • 财政年份:
    2017
  • 资助金额:
    $ 34.75万
  • 项目类别:
    Standard Grant
Collaborative Proposal: INFEWS N/P/H2O: Supramolecular Recognition in the Biocatalytic Transformation of Organic Phosphorus-Containing Environmental Matrices
合作提案:INFEWS N/P/H2O:含有机磷环境基质生物催化转化中的超分子识别
  • 批准号:
    1709626
  • 财政年份:
    2017
  • 资助金额:
    $ 34.75万
  • 项目类别:
    Standard Grant
EAGER: A Novel Approach for Molecular-Scale Probing of Hierarchical Organic Assemblies at Mineral Interfaces
EAGER:一种分子尺度探测矿物界面分层有机组装体的新方法
  • 批准号:
    1646815
  • 财政年份:
    2016
  • 资助金额:
    $ 34.75万
  • 项目类别:
    Continuing Grant
Early Career: Upgrade of an X-ray Diffractometer with Capillary & Humidity-Temperature Stages for Suspension & Hydrated Powder Measurements, and Outreach for Geochemistry R
早期职业生涯:带毛细管的 X 射线衍射仪升级
  • 批准号:
    1343063
  • 财政年份:
    2014
  • 资助金额:
    $ 34.75万
  • 项目类别:
    Standard Grant
Research Starter Grant: Metabolic Pathways in Bacterial Utilization of Hemicellulosic Sugars
研究启动资金:细菌利用半纤维素糖的代谢途径
  • 批准号:
    1337292
  • 财政年份:
    2013
  • 资助金额:
    $ 34.75万
  • 项目类别:
    Standard Grant
NSF Minority Postdoctoral Research Fellowship for FY2008
2008 财年 NSF 少数族裔博士后研究奖学金
  • 批准号:
    0805498
  • 财政年份:
    2009
  • 资助金额:
    $ 34.75万
  • 项目类别:
    Fellowship Award

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单细胞代谢组学的下一代质谱分析
  • 批准号:
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  • 财政年份:
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转变:代谢组学驱动的对协调代谢反应和合成生物学底盘适应性进化的规则的理解
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职业:用于生物研究的高场和台式 NMR 的开放获取、实时高通量代谢组学
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  • 财政年份:
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  • 项目类别:
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