Glutamatergic contributions to nicotine-induced cognitive enhancement

谷氨酸对尼古丁诱导的认知增强的贡献

• 批准号: 24510962
• 负责人: Professor René Hurlemann, Ph.D.
• 金额: --
• 依托单位: Universitätsklinik für Psychiatrie und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/24510962?language=en
• 关键词: Glutamatergic; contributions; nicotine; induced; cognitive

The neuroscience of social interaction rapidly grows in importance. Key among the neural substrates of emotion processing in social interaction is the amygdala. The amygdala is known to orchestrate aversive and appetitive reinforcement learning through the monitoring of environmental signals of positive and negative emotional value. The most prototypical such signal is the human face, and both fearful and happy faces act as reinforcers in that they enable the observer to rapidly learn which behaviors or objects to approach or avoid. Accumulating evidence suggests that reinforcement learning is dysfunctional in drug addiction. Central to the proposed fMRI project is the assumption that if (1) amygdala function is critical for reinforcement learning, and if (2) nicotine addiction is associated with dysregulated reinforcement learning, then nicotineaddicted subjects should present with amygdala dysfunction. Specifically, we hypothesize that functional, volumetric, and topological abnormalities may exist in the amygdala of nicotine-dependent subjects that may either represent a predisposition to nicotine addiction or a nicotine-induced neuroadaptation. The proposed fMRI project specifically addresses the effects of nicotine dependence on amygdala-dependent emotion pocessing in social stimuli. Given the observation of higher rates of nicotine dependence among female than male smokers, we hypothesize that the amygdala s functional, volumetric, and topological abnormalities may be more pronounced in women than in men.

社会互动的神经科学的重要性迅速增长。杏仁核是社会交往中情绪处理的关键神经基质。杏仁核通过监测积极和消极情绪价值的环境信号来协调厌恶和食欲强化学习。最典型的这种信号是人脸，恐惧和快乐的脸都可以作为观察者，使观察者能够迅速了解哪些行为或物体要接近或避开。越来越多的证据表明，强化学习在药物成瘾中是功能失调的。功能磁共振成像项目的核心假设是：如果（1）杏仁核功能对强化学习至关重要，如果（2）尼古丁成瘾与失调的强化学习有关，那么尼古丁成瘾的受试者应该表现出杏仁核功能障碍。具体而言，我们假设尼古丁依赖受试者的杏仁核中可能存在功能、体积和拓扑异常，这可能代表尼古丁成瘾的易感性或尼古丁诱导的神经适应。拟议的功能磁共振成像项目专门解决尼古丁依赖对杏仁核依赖的情绪处理在社会刺激的影响。鉴于女性吸烟者的尼古丁依赖率高于男性吸烟者，我们假设女性的杏仁核功能、体积和拓扑异常可能比男性更明显。

项目成果

A negative emotional and economic judgment bias in major depression

• DOI: 10.1007/s00406-013-0392-5
• 发表时间: 2013-12-01
• 期刊: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
• 影响因子: 4.7
• 作者: Scheele, Dirk;Mihov, Yoan;Hurlemann, Ren
• 通讯作者: Hurlemann, Ren

Overnight deprivation from smoking disrupts amygdala responses to fear

• DOI: 10.1002/hbm.21293
• 发表时间: 2011-05
• 期刊: Human Brain Mapping
• 影响因子: 4.8
• 作者: O. Onur;Alexandra Patin;Y. Mihov;B. Buecher;B. Stoffel‐Wagner;T. Schlaepfer;H. Walter;W. Maier;R. Hurlemann

Nicotinic Acetylcholine Receptors Contribute to Learning-induced Metaplasticity in the Hippocampus

烟碱乙酰胆碱受体有助于海马体学习诱导的可塑性

• DOI: 10.1162/jocn_a_00383
• 发表时间: 2013-07
• 期刊: Journal of Cognitive Neuroscience
• 影响因子: 3.2
• 作者: Klein, EM;Striepens N;Mihov Y;Schlaepfer TE;Reul J;Goossens L;Schruers K;Kendrick KM;Hurlemann, R
• 通讯作者: Hurlemann, R

Deciphering the neural signature of conversion blindness.

• DOI: 10.1176/appi.ajp.2012.12070905
• 发表时间: 2013
• 期刊: The American journal of psychiatry
• 作者: B. Becker;D. Scheele;R. Moessner;W. Maier;R. Hurlemann

Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam

• DOI: 10.1111/j.1528-1167.2012.03603.x
• 发表时间: 2013-01-01
• 期刊: EPILEPSIA
• 影响因子: 5.6
• 作者: Helmstaedter, Christoph;Mihov, Yoan;Hurlemann, Rene
• 通讯作者: Hurlemann, Rene