Neural activation patterns in cannabis- and amphetamine-dependent individuals: alterations after 28-days of abstinence and prospective associations with relapse risk

大麻和安非他明依赖者的神经激活模式：戒断 28 天后的变化以及与复发风险的前瞻性关联

• 批准号: 266395404
• 负责人: Professor René Hurlemann, Ph.D.
• 金额: --
• 依托单位: University of Electronic Science and Technology of China
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/266395404?language=en
• 关键词: Neural; activation; patterns; cannabis; amphetamine

Addiction is a major health problem worldwide. In particular, the persistent drug craving after detoxification and the high relapse rates represent challenging problems for both the individual and society. Addiction has generally been defined as a chronic, relapsing, neurobiological disease characterized by drug intoxication, craving, bingeing, and withdrawal accompanied by loss of control over drug related behaviors. Converging lines of evidence suggest that the transition from drug use to addiction is associated with altered processing in brain circuits subserving cognition, emotion and motivation. The proposed functional MRI project aims to (1) examine common and distinct alterations in motivational and emotional processing in cannabis- and amphetamine-addicted individuals, and (2) to assess to what extend these alterations represent common or substance-specific predictors of an increased relapse risk. To this end we intend to recruit separate samples of individuals with either cannabis- or amphetamine-addictions before they enter treatment in a specialized local clinic. To examine altered motivational and emotional processing the drug-addicted samples will be compared with a group of non-using controls. To control for confounding (sub-)acute effects of substance intake all participants will undergo 28-days of supervised abstinence before the examination. To further examine the predictive value of the assessed behavioral and neural indices of motivational and emotional functioning and relapse risk participants will be followed-up for a period of 12 months after the initial examination. During the functional MRI examination the integrity of three domains will be challenged that are key to successful long-term abstinence: (i) emotional and behavioral regulation, (ii) stress regulation, and (iii) reactivity to drug-associated cues. We expect that the findings from the present project may help to identify individuals with an increased relapse risk. Moreover, the findings from the present project may help to develop more efficient and substance-specific treatment approaches for cannabis and amphetamine addiction.

成瘾是世界范围内的一个主要健康问题。特别是，戒毒后对毒品的持续渴望和高复吸率对个人和社会都是具有挑战性的问题。成瘾通常被定义为一种慢性、复发性、神经生物学疾病，其特征为药物中毒、渴求、暴食和戒断，并伴有对药物相关行为的失控。越来越多的证据表明，从吸毒到成瘾的转变与大脑回路中有利于认知、情感和动机的处理过程的改变有关。拟议的功能性MRI项目旨在（1）检查大麻和安非他明成瘾者的动机和情绪处理中常见和独特的改变，以及（2）评估这些改变在多大程度上代表复发风险增加的常见或物质特异性预测因子。为此，我们打算在大麻或安非他明成瘾者进入当地专门诊所接受治疗之前，招募单独的样本。为了检查改变的动机和情绪处理，将吸毒成瘾的样本与一组不使用控制进行比较。为了控制物质摄入的混杂（亚）急性效应，所有受试者在检查前将接受28天的监督禁欲。为了进一步检查评估的动机和情绪功能的行为和神经指标的预测价值以及复发风险，参与者将在初次检查后随访12个月。在功能性MRI检查期间，三个领域的完整性将受到挑战，这三个领域是成功长期禁欲的关键：（i）情绪和行为调节，（ii）压力调节，以及（iii）对药物相关线索的反应。我们希望本项目的研究结果可能有助于识别复发风险增加的个体。此外，本项目的研究结果可能有助于为大麻和苯丙胺成瘾制定更有效和针对具体物质的治疗方法。

项目成果

Impaired cognitive performance under psycho-social stress in cannabis dependence is mediated by attenuated precuneus activity

• DOI: 10.1101/429951
• 发表时间: 2018-09
• 期刊: bioRxiv
• 作者: Weihua Zhao;Kaeli Zimmermann;Xinqi Zhou;F. Zhou;M. Fu;Christian Dernbach;D. Scheele;B. Weber;M. Eckstein;R. Hurlemann;K. Kendrick;B. Becker

Emotion regulation deficits in regular marijuana users

经常吸食大麻的人的情绪调节缺陷

• DOI: 10.1002/hbm.23671
• 发表时间: 2017-08-01
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Zimmermann, Kaeli;Walz, Christina;Becker, Benjamin
• 通讯作者: Becker, Benjamin

Cue-reactivity in the ventral striatum characterizes heavy cannabis use, whereas reactivity in the dorsal striatum mediates dependent use

• DOI: 10.1101/516385
• 发表时间: 2019-01
• 期刊: bioRxiv
• 作者: Xinqi Zhou;Kaeli Zimmermann;F. Xin;Weihua Zhao;Roelinka T Derckx;Anja Sassmannshausen;D. Scheele;R. Hurlemann;B. Weber;K. Kendrick;B. Becker

Altered striatal reward processing in abstinent dependent cannabis users: Social context matters

戒断依赖大麻使用者纹状体奖励处理的改变：社会背景很重要

• DOI: 10.1016/j.euroneuro.2019.01.106
• 发表时间: 2019
• 期刊: European Neuropsychopharmacology
• 影响因子: 5.6
• 作者: Zimmermann Kaeli;Kendrick Keith M.;Scheele Dirk;Dau Wolfgang;Banger Markus;Maier Wolfgang;Weber Bernd;Ma Yina;Hurlemann Rene;Becker Benjamin
• 通讯作者: Becker Benjamin

Altered orbitofrontal activity and dorsal striatal connectivity during emotion processing in dependent marijuana users after 28 days of abstinence

戒除 28 天后依赖大麻使用者情绪处理过程中眶额活动和背侧纹状体连接的改变

• DOI: 10.1007/s00213-017-4803-6
• 发表时间: 2017-12
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Zimmermann Kaeli;Yao Shuxia;Heinz Marcel;Zhou Feng;Dau Wolfgang;Banger Markus;Weber Bernd;Hurlemann Ren;Becker Benjamin
• 通讯作者: Becker Benjamin