CAREER: Incorporating host phenology into the framework of biodiversity-disease relationships

职业：将寄主物候纳入生物多样性与疾病关系的框架中

• 批准号: 2044897
• 负责人: Catherine Searle
• 金额: $ 91.33万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2044897&HistoricalAwards=false
• 关键词: CAREER; Incorporating; host; phenology; into

Major changes to biodiversity are occurring around the world - this can alter the risk of disease. Understanding and predicting how these changes impact infectious disease requires knowledge of the relationship between biodiversity and disease. However, because biodiversity may vary throughout the year, it can be difficult to measure host diversity and the contribution of each species to disease transmission. Therefore, scientists must understand how the seasonality of organisms in a community affects the risk of disease. In this project, researchers will study seasonal changes to amphibian biodiversity and how these changes impact infection with a fungus. A greater understanding of biodiversity-disease relationships is essential for effective control of emerging infectious diseases and management of susceptible species. This CAREER project also incorporates educational activities that focus on increasing the diversity of students who receive training in the scientific process by providing research opportunities for undergraduate and high school students. This study will combine field sampling, experimental manipulations, and modeling to incorporate host phenology into the study of biodiversity-disease relationships. The project focuses on the following complementary objectives: (1) enhance estimates of host competence for individual species by incorporating data on temporal habitat use, (2) quantify the temporal niche of a pathogen in communities with varying species composition, and (3) predict the effects of climate change on disease risk via altered host phenology. This work will address these objectives by utilizing an amphibian-fungal pathogen system, where the presence of amphibian host species in the aquatic environment varies seasonally and across space. The educational objectives of this CAREER project focus on increasing the diversity of students receiving quality training in the scientific process. Educational activities include (1) improving the availability of course-based undergraduate research experiences, (2) increasing the diversity of undergraduate research interns, and (3) engaging high school students in research through participation in science fairs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物多样性的重大变化正在世界各地发生 - 这可能会改变疾病的风险。理解和预测这些变化如何影响传染病需要了解生物多样性与疾病之间的关系。但是，由于生物多样性在全年中可能有所不同，因此很难衡量宿主的多样性以及每个物种对疾病传播的贡献。因此，科学家必须了解社区中生物的季节性如何影响疾病的风险。在该项目中，研究人员将研究两栖动物生物多样性的季节性变化以及这些变化如何影响真菌感染。对生物多样性 - 疾病关系的更多了解对于有效控制新兴的传染病和对易感物种的管理至关重要。该职业项目还纳入了教育活动，专注于通过为本科和高中生提供研究机会来增加在科学过程中接受培训的学生的多样性。这项研究将结合现场采样，实验操作和建模，以将宿主物候术纳入生物多样性疾病关系的研究。该项目的重点是以下互补目标：（1）通过纳入有关时间栖息地使用的数据来增强单个物种的宿主能力估计，（2）量化物种组成不同的社区的病原体的时间段，（3）通过改变宿主的宿主现象来预测气候变化对疾病风险的影响。这项工作将通过利用两栖动物的病原体系统来解决这些目标，在水生环境中，两栖宿主物种的存在在季节性和空间上都有变化。这个职业项目的教育目标着重于增加接受科学过程中高质量培训的学生的多样性。教育活动包括（1）提高基于课程的本科研究经验的可用性，（2）增加本科研究实习生的多样性，以及（3）通过参加科学博览会的参与来使高中生参与研究。这奖反映了NSF的法定任务，并通过基金会的知识优点和广泛的criperia criperia criperia criperia criperia criperia criperia criptia rection the Awsion。