BEE: Evolutionary rescue in response to infectious disease: when will populations be rescued from pathogens?

BEE：应对传染病的进化救援：何时才能将人群从病原体中拯救出来？

• 批准号: 1856710
• 负责人: Catherine Searle
• 金额: $ 40.14万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1856710&HistoricalAwards=false
• 关键词: BEE; Evolutionary; rescue; response; infectious

Many species and populations are threatened by rapidly changing environmental conditions, including the introduction of novel infectious diseases. As outbreaks of infectious diseases get more common and severe, understanding how populations can survive when faced with deadly pathogens is increasingly important. Evolutionary rescue, which happens when a population evolves to survive environmental change that would otherwise cause extinction, may provide a way for some populations to persist in a changing world. Most studies of evolutionary rescue have focused on non-living drivers of environmental change (e.g., pollution, extreme temperatures), with little known regarding the role that evolutionary rescue plays in response to disease. In this project researchers will study a species of water flea (Daphnia) whose populations' challenges due to both non-living environmental change and pathogen infection are well known. By identifying the conditions that allow a population of water fleas to experience evolutionary rescue in response to disease the researchers will gain knowledge that will help in management and control of infectious diseases in many other systems. This project will also train graduate and undergraduate students with a focus on those from underrepresented groups. Additionally, the investigators will develop interactive classroom activities for undergraduate biology courses and organize a workshop to train early-career scientists in methods of modeling infectious disease. The investigators will combine experimental manipulations, genotyping, transcriptomics, and modeling to study evolutionary rescue in response to the introduction of a pathogen. They will address the following complementary questions: (1) How does evolutionary rescue in response to a pathogen differ from evolutionary rescue in response to an abiotic stressor? (2) Can abiotic stress facilitate evolutionary rescue from disease? and (3) What are the effects of community diversity on a population's evolutionary response to a pathogen? The proposed work will address these questions by utilizing a highly tractable Daphnia-pathogen system to perform experimental manipulations of populations at multiple scales (laboratory to outdoor mesocosm) while tracking demographic and genetic changes through time. Experimental manipulations will be paired with modeling efforts to identify mechanisms and generalize the results to additional host-pathogen systems. This approach will provide novel insight into how populations can respond and recover from outbreaks of infectious disease.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

许多物种和种群受到迅速变化的环境条件的威胁，包括新传染病的传入。随着传染病的爆发变得越来越普遍和严重，了解人类在面对致命病原体时如何生存变得越来越重要。进化拯救（Evolutionary rescue）是指一个种群为了在可能导致灭绝的环境变化中生存而进化，这可能为一些种群在不断变化的世界中生存提供了一种方法。大多数关于进化救援的研究都集中在环境变化的非生物驱动因素（如污染、极端温度）上，而对进化救援在疾病反应中所起的作用知之甚少。在本项目中，研究人员将研究一种水蚤（Daphnia），其种群因非生物环境变化和病原体感染而面临的挑战是众所周知的。通过确定允许水蚤种群在对疾病的反应中经历进化拯救的条件，研究人员将获得有助于在许多其他系统中管理和控制传染病的知识。该项目还将培训研究生和本科生，重点是来自代表性不足群体的学生。此外，研究人员将为本科生物学课程开发互动式课堂活动，并组织一个讲习班，培训早期职业科学家在传染病建模方法方面的工作。研究人员将结合实验操作、基因分型、转录组学和建模来研究对病原体引入的反应的进化拯救。他们将解决以下补充问题：(1)应对病原体的进化救援与应对非生物应激源的进化救援有何不同？(2)非生物应激能否促进疾病的进化拯救？(3)群落多样性对种群对病原体的进化反应有何影响？提出的工作将通过利用高度可处理的水蚤-病原体系统在多个尺度（实验室到室外中尺度）对种群进行实验操作，同时跟踪人口统计和遗传变化，来解决这些问题。实验操作将与建模工作配对，以确定机制并将结果推广到其他宿主-病原体系统。这种方法将为人们如何应对和从传染病爆发中恢复提供新的见解。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Evolutionary rescue in host‐pathogen systems*

宿主病原体系统的进化拯救*

• DOI: 10.1111/evo.14269
• 发表时间: 2021
• 期刊: Evolution
• 影响因子: 3.3
• 作者: Searle, Catherine L.;Christie, Mark R.
• 通讯作者: Christie, Mark R.

Epidemics in native species influence the outcome of a species invasion

本地物种的流行病影响物种入侵的结果

• DOI: 10.1007/s00442-023-05444-4
• 发表时间: 2024
• 期刊: Oecologia
• 影响因子: 2.7
• 作者: Blackwood, Paradyse E.;Jonasen, Kacie L.;Hoenig, Brandon D.;Heil, Brittany N.;Searle, Catherine L.
• 通讯作者: Searle, Catherine L.

Ecological correlates of extinction risk and persistence of direct-developing stream-dwelling frogs in Mesoamerica

中美洲直接发育的溪流蛙的灭绝风险和持久性的生态相关性

• DOI: 10.1016/j.gecco.2022.e02197
• 发表时间: 2022
• 期刊: Global Ecology and Conservation
• 影响因子: 4
• 作者: Zumbado-Ulate, Hector;Neam, Kelsey;García-Rodríguez, Adrián;Ochoa-Ochoa, Leticia;Chaves, Gerardo;Kolby, Jonathan E.;Granados-Martínez, Sofía;Hertz, Andreas;Bolaños, Federico;Ariano-Sánchez, Daniel
• 通讯作者: Ariano-Sánchez, Daniel

The effects of parasite exposure on mortality from aquatic contaminants, carbaryl and elevated salinity, in a freshwater crustacean

淡水甲壳动物中寄生虫暴露对水生污染物、西维因和盐度升高造成的死亡率的影响

• DOI: 10.1093/plankt/fbaa023
• 发表时间: 2020
• 期刊: Journal of Plankton Research
• 影响因子: 2.1
• 作者: Ilmain, Juliana K;Searle, Catherine L
• 通讯作者: Searle, Catherine L