I-Corps: Biodegradable device for the surgical closure and structural support of luminal repairs

该I-Corps项目更广泛的影响/商业潜力是开发Bio-Zipper技术，以改善与下尿路重建（LUTR）手术相关的内部组织闭合的结果。 与外科医生、医疗保健提供者和机器人手术专家的合作将决定如何最好地开发、修改和优化Bio-Zipper，以确保它不仅高效，而且被该领域的领导者高度采用。一旦对该器械进行优化，以降低LUTR手术中成功内部闭合的障碍，则该器械的使用将扩展到具有挑战性的其他微创手术领域，例如胃肠道手术后的重建、阑尾手术和直肠切除术。Bio-Zipper将降低机器人手术成功的技能障碍，并提供一致、可靠的闭合方法。该器械根据靶组织进行了微小修改，可通过在临床挑战领域提供更多微创机器人手术选项来改善患者结局。该设备可能会推动更多医疗中心采用更复杂的机器人手术。I-Corps项目的重点是Bio-Zipper技术，该技术降低了下尿路重建手术中成功内部闭合的障碍。 该装置的使用还可以扩展到微创手术的其他领域，其中内部组织闭合具有挑战性。用于LUTR的Bio-Zipper管腔修复器械通过开发仿生粘合剂贴片直接解决了实践差距，该贴片的机械性能与其所应用的组织的机械性能相匹配。该器械专门设计用于确保整个修复过程中的张力分布，并在愈合过程中提供水密、稳定的支撑，尽管存在生理性间歇性膀胱充盈。该设备有可能通过快速、一致的闭合改善接受LUTR的儿童和成人的生活质量和结局，这将有助于过渡到微创、腔内、患者驱动的分流选择。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is a the development of a Bio-Zipper technology to improve outcomes in internal tissue closures related to Lower Urinary Tract Reconstructive (LUTR) surgery. Collaboration with surgeons, healthcare providers, and robotic surgery specialists will determine how to best develop, modify, and optimize the Bio-Zipper to ensure that it will not only be highly effective, but also highly adopted by leaders in the field. Once the device is optimized to lower the hurdles to successful internal closures in LUTR surgery, the device utilization will be expanded into other areas of minimally invasive surgery where internal tissue closure is challenging, such as reconstructions following gastrointestinal tract procedures, appendiceal procedures, and proctectomy. The Bio-Zipper will lower the skill-based barriers to successful robotic surgeries and provide a consistent, reliable closure method. This device, with small modifications based on the target tissue, may result in improved patient outcomes by allowing for more minimally-invasive robotic surgical options in clinically challenging areas. The device may drive the adoption of more complex robotic surgeries in a larger number of medical centers.This I-Corps project focuses on a Bio-Zipper technology that lowers the hurdles to successful internal closures in Lower Urinary Tract Reconstruction surgery. The use of the device may also be expanded into other areas of minimally-invasive surgery where internal tissue closures are challenging. The Bio-Zipper Luminal Repair Device for LUTR addresses practice gaps directly through the development of a biomimetic adhesive patch with mechanical properties tuned to those of the tissue to which it has been applied. The device is specifically designed to ensure distribution of tension across the repair and to provide watertight, stable support despite physiologic, intermittent bladder filling during the healing process. The device has the potential to improve quality of life and outcomes for children and adults undergoing LUTR via rapid, consistent closures that will facilitate the transition to minimally invasive, intracorporeal, patient-driven diversion selection.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.