PFI-TT: Development and Evaluation of an Absorbable Surgical Adhesive Patch to Reinforce Internal Suture Lines in the Urinary Tract

PFI-TT：用于加固尿路内部缝合线的可吸收手术粘合贴片的开发和评估

• 批准号: 2214057
• 负责人: Renea Sturm
• 金额: $ 25万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2214057&HistoricalAwards=false
• 关键词: PFI; TT; Development; Evaluation; Absorbable

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project will be to create a flexible, bioabsorbable, internal suture reinforcement device to significantly reduce post-operative complications and readmissions, decreasing hospitalization costs, and improving patient quality of life. The use of this device is anticipated to decrease total complications and readmissions by 20%, resulting in an average savings of $5,600 per procedure. This project will both evaluate the materials on tissue and digitally model tissue and materials for rapid device prototyping. Surgeon feedback will be used to further iterate the prototype to ensure that it is a readily applied closure system, optimized for surgeon use.The proposed project will develop a biodegradable, implantable, surgical closure device designed to consistently and reliably support and secure suture lines thereby promoting wound healing, regardless of tissue quality and/or surgeon experience. The initial development of this device will be for urinary tract reconstructive (UTR) procedures, including complex lower UTR (LUTR) such as bladder reconstruction, tissue closures following prostate surgery, and upper UTR such as ureteral procedures to facilitate drainage following kidney reconstruction. LUTRs, for example, involve long suture lines requiring significant skill and experience to minimize the post-operative complications. Additionally, in these cases, the tissue is often suboptimal resulting from aging, radiation, or fibrosis. The suture reinforcement device developed seeks to provide a technical solution designed to reduce complications and readmissions by reinforcing tissue and removing localized tension from the suture lines. The device will be designed to support the established method of tissue closure by reinforcing the suture lines already utilized by the surgeons. The proposed device would not significantly change the closure workflow and thus, would minimize any potential learning curve associated with the use of the device maximizing adoption.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该创新合作伙伴关系 - 技术转化 (PFI-TT) 项目的更广泛影响/商业潜力将是创建一种灵活的、生物可吸收的内部缝合加固装置，以显着减少术后并发症和再入院、降低住院费用并提高患者的生活质量。使用该设备预计可将总并发症和再入院率降低 20%，每次手术平均节省 5,600 美元。该项目将评估组织材料，并对组织和材料进行数字建模，以进行快速设备原型制作。外科医生的反馈将用于进一步迭代原型，以确保它是一个易于应用的闭合系统，并针对外科医生的使用进行了优化。拟议的项目将开发一种可生物降解、可植入的手术闭合装置，旨在始终可靠地支撑和固定缝合线，从而促进伤口愈合，无论组织质量和/或外科医生经验如何。该设备的初步开发将用于尿路重建 (UTR) 手术，包括复杂的下 UTR (LUTR)，如膀胱重建、前列腺手术后的组织闭合，以及上 UTR，如输尿管手术，以促进肾脏重建后的引流。例如，LUTR 涉及长缝合线，需要大量的技能和经验，以最大限度地减少术后并发症。此外，在这些情况下，组织通常由于老化、辐射或纤维化而达不到最佳状态。所开发的缝合加固装置旨在提供一种技术解决方案，旨在通过加固组织并消除缝合线上的局部张力来减少并发症和再入院。该装置的设计目的是通过加强外科医生已经使用的缝合线来支持既定的组织闭合方法。拟议的设备不会显着改变闭合工作流程，因此将最大限度地减少与设备使用相关的任何潜在学习曲线，从而最大限度地提高采用率。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

MP42-20 TO SEAL OR NOT TO SEAL: EXAMINING THE ROLE OF TISSUE ADHESIVES FOR BLADDER AND URETERAL RECONSTRUCTION

MP42-20——密封或不密封：检查组织粘合剂在膀胱和输尿管重建中的作用

• DOI: 10.1097/ju.0000000000003280.20
• 发表时间: 2023
• 期刊: Journal of Urology
• 影响因子: 6.6
• 作者: Ramirez, Juan;Aninwene, George E.;Sturm, Renea M.
• 通讯作者: Sturm, Renea M.