Brønsted Acid Activated Chiral Brønsted Bases: Catalysts for Enantioselective Photochemical and Aminyl Radical Reactions.

布朗斯台德酸激活手性布朗斯台德碱：对映选择性光化学和氨基自由基反应的催化剂。

• 批准号: DP0881137
• 负责人: Prof David Lupton
• 金额: $ 21.16万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-02 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0881137
• 关键词: Br; nsted; Acid; Activated; Chiral

In coming years the Australian pharmaceutical industry will face unprecedented challenges regarding the generation of wealth in an environmentally sustainable fashion. This proposal aims to address these issues through the development of a range of organocatalytic methods, which will provide access to valuable materials in a sustainable manner. While the new technologies derived from these studies will deliver general benefits in the area of chemical synthesis, more localised benefits will be achieved through the synthesis of the biologically significant Grandisine natural products, which have a possible role in the management of chronic pain.

在未来几年，澳大利亚制药业将面临前所未有的挑战，如何以环境可持续的方式创造财富。该提案旨在通过开发一系列有机催化方法来解决这些问题，这将以可持续的方式提供有价值的材料。虽然从这些研究中获得的新技术将在化学合成领域带来普遍益处，但通过合成具有生物学意义的Grandisine天然产物将实现更多的局部益处，这些天然产物可能在慢性疼痛管理中发挥作用。