Challenges to organocatalysis

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This project aims to use organocatalysis to generate organocatalytic C=C insertion, C-H functionalisation and carbonyl ylide/1,3-dipolar cycloaddition reactions. Organocatalysis has transformed the way chemical synthesis is performed. However, in the early years the focus of this discipline has primarily been enolate type chemistry, and more challenging reactions, such as those involving carbenoid intermediates, have not been contemplated. Previously such reactions have only been achieved using transition metal catalysts. This project addresses this limitation, allowing the strengths of organocatalysis (abundance and diversity, access to enantiopurity, elemental sustainability) to affect the broader landscape of catalysis. This approach could present an opportunity to examine reactivity patterns, stereoselectivity and cascade design and may lead to new reaction technologies.