Challenges to organocatalysis

有机催化面临的挑战

• 批准号: DP170103567
• 负责人: Prof David Lupton
• 金额: $ 22.11万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170103567
• 关键词: Challenges; organocatalysis

This project aims to use organocatalysis to generate organocatalytic C=C insertion, C-H functionalisation and carbonyl ylide/1,3-dipolar cycloaddition reactions. Organocatalysis has transformed the way chemical synthesis is performed. However, in the early years the focus of this discipline has primarily been enolate type chemistry, and more challenging reactions, such as those involving carbenoid intermediates, have not been contemplated. Previously such reactions have only been achieved using transition metal catalysts. This project addresses this limitation, allowing the strengths of organocatalysis (abundance and diversity, access to enantiopurity, elemental sustainability) to affect the broader landscape of catalysis. This approach could present an opportunity to examine reactivity patterns, stereoselectivity and cascade design and may lead to new reaction technologies.

该项目旨在使用有机催化来产生有机催化的C=C插入、C-H官能化和羰基叶立德/1，3-偶极环加成反应。有机催化已经改变了化学合成的方式。然而，在早期，这门学科的重点主要是烯醇化物类型的化学，更具有挑战性的反应，如涉及卡宾中间体的反应，还没有被考虑。以前，这种反应只能使用过渡金属催化剂来实现。该项目解决了这一限制，允许有机催化的优势（丰度和多样性，获得对映体纯度，元素可持续性）影响更广泛的催化景观。这种方法可以提供一个机会，检查反应模式，立体选择性和级联设计，并可能导致新的反应技术。