Challenges to organocatalysis

本项目旨在利用有机催化生成C=C插入、C- h功能化和羰基/1,3偶极环加成反应的有机催化。有机催化已经改变了化学合成的方式。然而，在早期，这一学科的重点主要是烯醇型化学，而更具有挑战性的反应，如那些涉及类碳中间体，还没有考虑到。以前，这样的反应只能用过渡金属催化剂来实现。该项目解决了这一限制，允许有机催化的优势（丰度和多样性，获得对映不纯性，元素可持续性）影响更广泛的催化景观。这种方法可以为研究反应性模式、立体选择性和级联设计提供机会，并可能导致新的反应技术。

This project aims to use organocatalysis to generate organocatalytic C=C insertion, C-H functionalisation and carbonyl ylide/1,3-dipolar cycloaddition reactions. Organocatalysis has transformed the way chemical synthesis is performed. However, in the early years the focus of this discipline has primarily been enolate type chemistry, and more challenging reactions, such as those involving carbenoid intermediates, have not been contemplated. Previously such reactions have only been achieved using transition metal catalysts. This project addresses this limitation, allowing the strengths of organocatalysis (abundance and diversity, access to enantiopurity, elemental sustainability) to affect the broader landscape of catalysis. This approach could present an opportunity to examine reactivity patterns, stereoselectivity and cascade design and may lead to new reaction technologies.