Pathophysiology Crystal-induced kidney injury

晶体可以通过许多不同的方式导致肾脏损伤，例如在胆固醇栓塞、肾小管内结晶或尿石症期间。在前一个项目中，我们能够生成有关草酸钙晶体引起的肾脏炎症的重要数据。在这里，我们建议对各种临床相关晶体诱导的肾脏免疫和非免疫细胞的激活和损伤进行系统的研究。此外，我们还将探索创新肾脏胆固醇栓塞症和尿酸盐肾病的疾病模型。此外，我们还将探讨晶体肉芽肿形成的分子机制。在系统研究的帮助下，该项目将揭开晶体肾病的分子病理生理学。

Crystals can induce kidney injury in many different ways, e.g. during cholesterol embolism, intratubular crystallization or during urolithiasis. In the previous project we were able to generate important data on calcium oxalate crystal-induced kidney inflammation. Here we propose systematic studies on the activation and injury of renal immune and non-immune cells induced by a great variety of clinically relevant crystals. In addition, we will explore innovate disease models of cholesterol embolism of the kidney and urate nephropathy. Furthermore, we will explore the molecular mechanisms of crystal granuloma formation. By the help of systematic studies this project will unravel the molecular pathophysiology of crystal nephropathies.