Neural Mechanisms of Task Specific Changes in Sensorimotor Processing

感觉运动处理中任务特定变化的神经机制

• 批准号: 246181773
• 负责人: Professor Dr. Ansgar Büschges
• 金额: --
• 依托单位: Institut für Zoologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/246181773?language=en
• 关键词: Neural; Mechanisms; Task; Specific; Changes

When animals move through their environment, they need to generate a motor output suitable for both propulsion as well as directing the animal towards goals that have been identified by means of visual, chemosensory, auditory or tactile cues. In the course of this task locomotor activity is modified to allow for the generation of curvatures in the locomotor path or to surpass or climb over obstacles. The neural networks generating the motor output for locomotion are localized in the segmented central nervous systems at the level of the locomotor organs: in insects, for example, these networks reside in the thoracic nerve cord. To generate locomotor behavior, these networks are under continuous descending control from higher brain regions. The descending signals not only maintain motor activity, but also allow for continuous modification and adjustment of the actual locomotor output to serve the behavioral needs described above. A change in walking direction is a simple and often necessary maneuver for approaching a goal. Asymmetric kinematics of leg movements on either side allow for such maneuver. At present it is not clear, how signals from higher order centers in the brain influence the segmental networks and which component neurons of the locomotor networks are affected in the course of generating goal directed locomotor behavior. This project aims to close this gap in knowledge working on the stick insect, an animal for which considerable detailed information on the role of segmental sensory feedback in the generation of single leg stepping is available. Previous studies in this animal gave rise to the hypothesis that modifications in the processing of sensory feedback within the segmental networks might in general contribute to such modifications. The project shall answer the following questions: 1. What modifications occur in the influence and processing of sensory feedback from ground contact, movement and load sensors in dependence of the behavioral task a single leg has to serve, i.e. as an outside or an inside leg in curve walking? 2. How is processing of movement signals underlying reinforcement of movement modified in order to serve the control of motor activity on either side of a curve walking animal? 3. Which component neurons in the segmental premotor network are influenced in order to allow for the above described modifications in the generation of a motor output for curve walking?

当动物在它们的环境中移动时，它们需要产生适合于推进以及引导动物朝向通过视觉、化学感觉、听觉或触觉线索识别的目标的运动输出。在这项任务的过程中，运动活动被修改，以允许在运动路径中产生弯曲或超越或爬过障碍物。产生运动输出的神经网络位于运动器官水平的分段中枢神经系统中：例如，在昆虫中，这些网络位于胸神经索中。为了产生运动行为，这些网络受到来自高级大脑区域的连续下行控制。下行信号不仅维持运动活动，而且允许对实际运动输出的连续修改和调整，以满足上述行为需求。改变行走方向是接近目标的一个简单而又必要的动作。两侧腿部运动的不对称运动学允许这种机动。目前尚不清楚来自大脑中高阶中心的信号如何影响节段网络，以及运动网络的哪些组成神经元在产生目标导向运动行为的过程中受到影响。这个项目的目的是缩小这方面的知识差距工作的竹节虫，动物的相当详细的信息，节段性的感觉反馈的作用，在单腿踏步。以前的研究在这种动物引起的假设，在节段性网络内的感觉反馈的处理的修改可能在一般情况下有助于这种修改。该项目应回答以下问题：1。根据一条腿必须执行的行为任务，即曲线行走中的外侧腿或内侧腿，在对来自地面接触、运动和负荷传感器的感觉反馈的影响和处理中发生了什么变化？2.如何处理运动信号的基础上加强运动的修改，以服务于控制运动活动的任何一侧的曲线行走的动物？3.为了允许在曲线行走的运动输出的生成中进行上述修改，节段性前运动网络中的哪些组成神经元受到影响？

项目成果

Effects of force detecting sense organs on muscle synergies are correlated with their response properties.

• DOI: 10.1016/j.asd.2017.05.004
• 发表时间: 2017-07
• 期刊: Arthropod structure & development
• 影响因子: 2
• 作者: Zill SN;Neff D;Chaudhry S;Exter A;Schmitz J;Büschges A
• 通讯作者: Büschges A

Force dynamics and synergist muscle activation in stick insects: the effects of using joint torques as mechanical stimuli.

竹节虫的力动力学和增效肌肉激活：使用关节扭矩作为机械刺激的效果

• DOI: 10.1152/jn.00371.2018
• 发表时间: 2018
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: Zill SN;Dallmann CJ;Büschges A;Chaudhry S;Schmitz J
• 通讯作者: Schmitz J

Body side-specific control of motor activity during turning in a walking animal

• DOI: 10.7554/elife.13799
• 发表时间: 2016-04-27
• 期刊: ELIFE
• 影响因子: 7.7
• 作者: Gruhn, Matthias;Rosenbaum, Philipp;Bueschges, Ansgar
• 通讯作者: Bueschges, Ansgar

Force feedback reinforces muscle synergies in insect legs.

力反馈增强昆虫腿部的肌肉协同作用

• DOI: 10.1016/j.asd.2015.07.001
• 发表时间: 2015
• 期刊: Arthropod structure & development
• 影响因子: 2
• 作者: Zill SN;Chaudry S;Büschges A;Schmitz J
• 通讯作者: Schmitz J

Identification of the origin of force-feedback signals influencing motor neurons of the thoraco-coxal joint in an insect

• DOI: 10.1007/s00359-019-01334-4
• 发表时间: 2019-04-01
• 期刊: JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
• 影响因子: 2.1
• 作者: Haberkorn, Anna;Gruhn, Matthias;Bueschges, Ansgar
• 通讯作者: Bueschges, Ansgar