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New Photocatalytic Systems for Efficient Organic Synthesis

用于高效有机合成的新型光催化系统

基本信息

批准号：
2102646
负责人：
Oleg Larionov
金额：
$ 47.5万
依托单位：
University of Texas at San Antonio
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2102646&HistoricalAwards=false
关键词：
New Photocatalytic Systems Efficient Organic

项目摘要

With the support of the Chemical Synthesis (SYN) program in the Division of Chemistry, Oleg V. Larionov of the University of Texas at San Antonio is developing new catalysts that use the energy of the visible light to enable previously unknown chemical reactions. The new catalysts enable the chemical reactions by selectively breaking chemical bonds that connect specific atoms within large molecules and replacing them with other groups of atoms, producing new and more complex molecules, while generating less waste and expending less non-renewable resources. The new reactions will simplify production of agrochemicals, medicines, and plastics. Additional societal benefits will include training of underrepresented groups in various aspects of chemical research and improvements in the chemical education through the development of an innovative workshop on sustainable technologies.Progress in the development of new catalytic transformations requires deeper understanding of mechanistic details of diverse catalytic systems. In this project, Oleg Larionov is advancing the discovery of new catalytic manifolds, enabling efficient and selective functionalizations of strong bonds by radical and radical-ionic pathways that become accessible upon photo-activation with visible light. He and his students are developing new photocatalysts, engaging substrates by means of directional catalyst–substrate interactions that provide the necessary selectivity in a departure from typical non-directional catalytic systems. The research is expected to streamline synthetic access to valuable functionalized materials and will add to the understanding of complex catalytic manifolds including those that will likely underpin future synthetic methodologies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学合成 (SYN) 项目的支持下，德克萨斯大学圣安东尼奥分校的 Oleg V. Larionov 正在开发新型催化剂，利用可见光的能量来实现以前未知的化学反应。新催化剂通过选择性地破坏连接大分子内特定原子的化学键并用其他原子团取代它们来实现化学反应，产生新的、更复杂的分子，同时产生更少的废物并消耗更少的不可再生资源。新反应将简化农用化学品、药品和塑料的生产。其他社会效益将包括在化学研究的各个方面对代表性不足的群体进行培训，以及通过开发可持续技术创新研讨会来改进化学教育。新催化转化的开发进展需要更深入地了解不同催化系统的机械细节。在这个项目中，Oleg Larionov 正在推进新催化歧管的发现，通过自由基和自由基离子途径实现强键的高效和选择性功能化，这些途径在可见光光活化后变得可访问。他和他的学生正在开发新型光催化剂，通过定向催化剂-基质相互作用来接合基质，从而提供必要的选择性，从而不同于典型的非定向催化系统。该研究预计将简化对有价值的功能化材料的合成获取，并将增进对复杂催化歧管的理解，包括那些可能支撑未来合成方法的催化歧管。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。