Controlled symmetry breaking in semicrystalline polymer crystalsomes
半结晶聚合物晶体体中的受控对称性破缺
基本信息
- 批准号:2104968
- 负责人:
- 金额:$ 63.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
NON-TECHNICAL SUMMARY:Semicrystalline polymers constitute the large majority of polymeric materials in use today. While the basic symmetries of polymer crystals are not different from their small molecular counterparts, the long-chain nature of polymers does significantly affect their crystallization behavior. Understanding the structure and morphology of semicrystalline polymers is crucial to improving their properties and broadening their applications. This project concerns the structural control of polymer crystals. The overarching goal of this research is to achieve unique spherical polymer crystals by controlling the crystallization conditions and/or the polymer molecular structure and to elucidate the morphology and the fundamental molecular-level processes involved in such curved-crystal growth. It is anticipated that these well-controlled spherical crystals may find applications in the fields of drug delivery and immunotherapy. The educational component of the proposal includes: 1) Mentoring graduate and undergraduate students. 2) Addressing the need for the education of modern polymer science by developing two class modules that will be used in graduate courses at Drexel University. 3) Involving high school students and teachers, particularly under-represented populations, in the proposed research activities.TECHNICAL SUMMARY: The long-chain nature of polymers brings the most interesting feature to their crystallization behavior: the intricate amorphous domains in a crystalline material. The hierarchical morphology of the intertwining crystalline and amorphous phases accounts for some unique properties of semicrystalline polymers. Based on the correlation between crystal morphology and translational symmetry, polymer crystals are divided into shape-symmetry commensurate crystals and shape-symmetry incommensurate crystals (SSICs). In the latter, crystal morphology dictates broken translational symmetry along at least one unit-cell axis. This project aims to systematically investigate a class of polymer spherical crystals in the context of SSICs. Two approaches, namely a top-down templating technique and a bottom-up molecular engineering method, will be employed to break the translational symmetry in polymer crystals. The recently discovered spherical crystalsomes will be used as the model system. Accordingly, the specific aims of the proposed work are: 1) Understanding curvature-dependent crystallization and melting in polymer crystalsomes. 2) Developing complex crystalsomes via morphological control. 3) Fabricating crystalsomes using spontaneous translational symmetry breaking. This project will advance the field of polymer crystallization and lead to a library of crystalsomes as tailor-designed polymeric nanoparticles. Potential applications for these include drug delivery and immunotherapy..This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
非技术概述:半结晶聚合物构成了当今使用的绝大多数聚合物材料。 虽然聚合物晶体的基本对称性与它们的小分子对应物没有什么不同,但聚合物的长链性质确实显著影响它们的结晶行为。了解半结晶聚合物的结构和形态对于改善其性能和拓宽其应用领域至关重要。本项目涉及聚合物晶体的结构控制。本研究的总体目标是通过控制结晶条件和/或聚合物分子结构来实现独特的球形聚合物晶体,并阐明这种弯曲晶体生长中所涉及的形态和基本分子水平过程。预期这些良好控制的球形晶体可在药物递送和免疫治疗领域中找到应用。该提案的教育部分包括:1)指导研究生和本科生。2)通过开发将用于德雷克塞尔大学研究生课程的两个课程模块,满足现代聚合物科学教育的需求。3)让高中学生和教师,特别是代表性不足的人群参与拟议的研究活动。技术概要:聚合物的长链性质为它们的结晶行为带来了最有趣的特征:结晶材料中复杂的无定形结构域。结晶相和非晶相相互缠绕的分级形态解释了半结晶聚合物的一些独特性质。根据晶体形态与平移对称性的关系,将聚合物晶体分为形状对称的公度晶体和形状对称的非公度晶体。在后者中,晶体形态决定了沿着至少一个晶胞轴的破缺平移对称性沿着。本研究旨在系统地研究一类聚合物球形晶体在SSICs中的应用。两种方法,即自上而下的模板技术和自下而上的分子工程方法,将被用来打破聚合物晶体中的平移对称性。最近发现的球形晶体体将被用作模型系统。因此,所提出的工作的具体目标是:1)理解曲率依赖的结晶和熔融聚合物晶体。2)通过形态学控制发育复杂的晶体体。3)利用自发平移对称破缺制造晶体体。该项目将推进聚合物结晶领域,并导致晶体体库作为定制设计的聚合物纳米颗粒。 这些的潜在应用包括药物递送和免疫治疗。该奖项反映了NSF的法定使命,并被认为是值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估的支持。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Colloidosome-Templated Poly (L-lactic acid) Crystalsomes
- DOI:10.1016/j.giant.2022.100124
- 发表时间:2022-10
- 期刊:
- 影响因子:7
- 作者:Mark C. Staub;Shichen Yu;Christopher Y. Li
- 通讯作者:Mark C. Staub;Shichen Yu;Christopher Y. Li
Poly (3‐hexylthiophene) (P3HT) Crystalsomes: Tiling 1D Polymer Crystals on a Spherical Surface
聚 (3-己基噻吩) (P3HT) 晶体:在球形表面上平铺一维聚合物晶体
- DOI:10.1002/marc.202200529
- 发表时间:2022
- 期刊:
- 影响因子:4.6
- 作者:Staub, Mark Clyde;Yu, Shichen;Li, Christopher Yuren
- 通讯作者:Li, Christopher Yuren
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Christopher Li其他文献
Chapter 102 – Snoring
第102章-打鼾
- DOI:
10.1016/b978-1-4160-6645-3.00102-x - 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Christopher Li;V. Hoffstein - 通讯作者:
V. Hoffstein
TOPOLOGY INFERENCE IN EVOLUTIONARY GAMES ON GRAPHS
图进化博弈中的拓扑推理
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
Christopher Li;Wenjun Chen;Santiago Segarra - 通讯作者:
Santiago Segarra
Pilot Evaluation of a Dementia Case Finding Clinical Service Using the Informant AD8 for At-Risk Older Adults in Primary Health Care: A Brief Report.
使用 Informal AD8 为初级卫生保健中的高危老年人进行痴呆症病例寻找临床服务的试点评估:简要报告。
- DOI:
10.1016/j.jamda.2016.04.027 - 发表时间:
2016 - 期刊:
- 影响因子:7.6
- 作者:
M. A. Shaik;Chia Hui Khoo;Anandan Gerard Thiagarajah;N. Tan;Christopher Li;Jing Xu;Yanhong Dong - 通讯作者:
Yanhong Dong
Laboratories of Democracy: Policy Experimentation under Decentralization *
民主实验室:权力下放下的政策实验*
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
Chen Cheng;Christopher Li;Scott Ashworth;Daniel Diermeier;Georgy Egorov;Timothy Feddersen;Matthew Jackson;Samir Mamadehussene;Roger Myerson;Wojciech Olszewski;Nicola Persico;Bruno H. Strulovici;Yiqing Xing - 通讯作者:
Yiqing Xing
A theory of strategic voting with non-instrumental motives
- DOI:
10.1007/s00355-020-01250-6 - 发表时间:
2020-03-17 - 期刊:
- 影响因子:0.800
- 作者:
Christopher Li;Ricardo Pique - 通讯作者:
Ricardo Pique
Christopher Li的其他文献
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{{ truncateString('Christopher Li', 18)}}的其他基金
MRI: Acquisition of an advanced scanning electron microscope for in situ and in operando materials characterization and education
MRI:购买先进的扫描电子显微镜,用于原位和操作材料表征和教育
- 批准号:
2117602 - 财政年份:2021
- 资助金额:
$ 63.67万 - 项目类别:
Standard Grant
Multifunctional solid polymer electrolytes for all-solid-state batteries
全固态电池用多功能固体聚合物电解质
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2033882 - 财政年份:2020
- 资助金额:
$ 63.67万 - 项目类别:
Standard Grant
Multifunctional 2D Polymers and Hybrids via Crystal Engineering
通过晶体工程实现多功能二维聚合物和杂化物
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1762626 - 财政年份:2018
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$ 63.67万 - 项目类别:
Standard Grant
Confined and Directed Polymer Crystallization at Curved Liquid/Liquid Interface
弯曲液/液界面处的限域定向聚合物结晶
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1709136 - 财政年份:2017
- 资助金额:
$ 63.67万 - 项目类别:
Standard Grant
Collaborative Research: Polymer Single Crystal-Assisted "Grafting From": A Versatile Approach towards Multicomponent Polymer Brushes with Well-Defined Architectures and Grafting
合作研究:聚合物单晶辅助“接枝”:具有明确结构和接枝的多组分聚合物刷的多功能方法
- 批准号:
1709119 - 财政年份:2017
- 资助金额:
$ 63.67万 - 项目类别:
Standard Grant
SusChEM: Hybrid and Double Network Solid Polymer Electrolytes
SusChEM:混合和双网络固体聚合物电解质
- 批准号:
1603520 - 财政年份:2016
- 资助金额:
$ 63.67万 - 项目类别:
Standard Grant
Biomimetic Mineralization by Combining Block Copolymer Self-Assembly and One Dimensional Crystal Nucleation
结合嵌段共聚物自组装和一维晶体成核的仿生矿化
- 批准号:
1507760 - 财政年份:2015
- 资助金额:
$ 63.67万 - 项目类别:
Continuing Grant
UNS: Ion transport in semicrystalline solid polymer electrolytes
UNS:半结晶固体聚合物电解质中的离子传输
- 批准号:
1510092 - 财政年份:2015
- 资助金额:
$ 63.67万 - 项目类别:
Standard Grant
Self and Programmable Assembly of Nanoparticles with Multicompartment Polymer Brushes
使用多室聚合物刷进行纳米颗粒的自组装和可编程组装
- 批准号:
1438240 - 财政年份:2014
- 资助金额:
$ 63.67万 - 项目类别:
Standard Grant
Polymer Crystallization at Curved Liquid/Liquid Interface
弯曲液/液界面处的聚合物结晶
- 批准号:
1308958 - 财政年份:2013
- 资助金额:
$ 63.67万 - 项目类别:
Continuing Grant
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