Biomimetic Mineralization by Combining Block Copolymer Self-Assembly and One Dimensional Crystal Nucleation

结合嵌段共聚物自组装和一维晶体成核的仿生矿化

基本信息

  • 批准号:
    1507760
  • 负责人:
  • 金额:
    $ 45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-09-01 至 2018-08-31
  • 项目状态:
    已结题

项目摘要

Non-technical: This award by the Biomaterials program in the Division of Materials Research to Drexel University aims to use a "bottom-up", directed assembly method to mimic the natural bone structure, and to understand the origin of the properties of natural bone. Bone is the second most commonly transplanted tissue; over 2.2 million bone graft procedures are performed annually worldwide. Knowledge gained from the study will not only help to develop new generation bone mimics for tissue engineering, it will also shed light on novel hybrid materials design towards stronger and lighter nanocomposites. The educational component of the proposal includes: 1) developing two class modules addressing natural materials properties; 2) mentoring graduate and undergraduate students; and 3) involving high school students and teachers, particularly from underrepresented minority groups, in the proposed research activities. These educational activities encompass the following broad impacts: 1) the proposed plans will help bridge the existing gap between levels of educational developments by involving high school students and teachers in research activities; and 2) the proposed outreach program will be specifically geared towards encouraging the participation of underrepresented minority groups in the Philadelphia region.Technical: Despite various macro-structures, morphogenically different bones share similar nanostructures consisting of collagen fibrils within which organized hydroxyapatite nanocrystals are embedded with a period of 67 nm along the fibrils, and these nanocrystals are aligned parallel to the fibril axis. Synthetic soft materials have been used to successfully to control the orientation of mineral crystals. The spatial distribution of minerals in a synthetic scaffold, however, has yet to be reproduced in a biomimetic manner. The proposed design aims to mimic the hierarchical structure of natural bone on the molecular level. The investigators will combine one-dimensional nucleation and block copolymer (BCP) self-assembly to achieve this goal. By controlling crystallization of carefully selected BCP on 1D polymer nanofibers, because of depletion-induced concentration gradients, the crystal growth follows a periodic pattern with the period ranging from a few terns to hundreds of nanometers. The chemical environment in the vicinity of the BCP crystals can be tuned to allow nanoconfined biomineralization. Through this approach, for the first time, both the orientation and spatial distribution of the mineral nanocrystals can be precisely controlled. Changing BCP molecular weight also allows detailed morphological and structural control of the biomineralization process. These researchers anticipate that the unprecedented structural control will provide a new route for biomimetic design of hybrid materials in general and bone mimics in particular. The broader impact activities include mentoring high school students and teachers with a focus on underrepresented groups from the Philadelphia region.
非技术性:该奖项由德雷克塞尔大学材料研究部的生物材料项目授予,旨在使用“自下而上”的定向组装方法来模拟天然骨骼结构,并了解天然骨骼特性的起源。 骨是第二大最常见的移植组织;全世界每年进行超过220万例骨移植手术。从这项研究中获得的知识不仅有助于开发新一代组织工程骨模拟物,还将为新型混合材料设计提供更强,更轻的纳米复合材料。该提案的教育部分包括:1)开发两个课程模块,解决天然材料的特性; 2)指导研究生和本科生; 3)让高中学生和教师,特别是来自代表性不足的少数群体的学生和教师参与拟议的研究活动。这些教育活动包括以下广泛的影响:1)拟议的计划将有助于弥合教育发展水平之间的现有差距,让高中学生和教师参与研究活动; 2)拟议的推广计划将专门针对鼓励费城地区代表性不足的少数群体的参与。技术:尽管有各种宏观结构,但形态学上不同的骨共享由胶原原纤维组成的相似纳米结构,在所述胶原原纤维内,有序的羟基磷灰石纳米晶体以沿着原纤维的67 nm的周期嵌入,并且这些纳米晶体平行于原纤维轴排列。合成软材料已被成功地用于控制矿物晶体的取向。然而,矿物在合成支架中的空间分布还有待于以仿生方式再现。所提出的设计旨在在分子水平上模仿天然骨的分级结构。 研究人员将结合联合收割机一维成核和嵌段共聚物(BCP)自组装来实现这一目标。 通过控制在一维聚合物纳米纤维上仔细选择的BCP的结晶,由于耗尽诱导的浓度梯度,晶体生长遵循周期性图案,周期范围从几个纳米到数百纳米。 可以调整嵌段共聚物晶体附近的化学环境以实现纳米限制的生物矿化。通过这种方法,第一次可以精确控制矿物纳米晶体的取向和空间分布。改变BCP分子量还允许对生物矿化过程进行详细的形态和结构控制。 这些研究人员预计,前所未有的结构控制将提供一个新的路线,仿生设计的混合材料,特别是骨模拟。更广泛的影响活动包括指导高中学生和教师,重点是费城地区代表性不足的群体。

项目成果

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Christopher Li其他文献

Chapter 102 – Snoring
第102章-打鼾
  • DOI:
    10.1016/b978-1-4160-6645-3.00102-x
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Christopher Li;V. Hoffstein
  • 通讯作者:
    V. Hoffstein
TOPOLOGY INFERENCE IN EVOLUTIONARY GAMES ON GRAPHS
图进化博弈中的拓扑推理
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Christopher Li;Wenjun Chen;Santiago Segarra
  • 通讯作者:
    Santiago Segarra
Pilot Evaluation of a Dementia Case Finding Clinical Service Using the Informant AD8 for At-Risk Older Adults in Primary Health Care: A Brief Report.
使用 Informal AD8 为初级卫生保健中的高危老年人进行痴呆症病例寻找临床服务的试点评估:简要报告。
Laboratories of Democracy: Policy Experimentation under Decentralization *
民主实验室:权力下放下的政策实验*
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Chen Cheng;Christopher Li;Scott Ashworth;Daniel Diermeier;Georgy Egorov;Timothy Feddersen;Matthew Jackson;Samir Mamadehussene;Roger Myerson;Wojciech Olszewski;Nicola Persico;Bruno H. Strulovici;Yiqing Xing
  • 通讯作者:
    Yiqing Xing
A theory of strategic voting with non-instrumental motives
  • DOI:
    10.1007/s00355-020-01250-6
  • 发表时间:
    2020-03-17
  • 期刊:
  • 影响因子:
    0.800
  • 作者:
    Christopher Li;Ricardo Pique
  • 通讯作者:
    Ricardo Pique

Christopher Li的其他文献

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{{ truncateString('Christopher Li', 18)}}的其他基金

MRI: Acquisition of an advanced scanning electron microscope for in situ and in operando materials characterization and education
MRI:购买先进的扫描电子显微镜,用于原位和操作材料表征和教育
  • 批准号:
    2117602
  • 财政年份:
    2021
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Controlled symmetry breaking in semicrystalline polymer crystalsomes
半结晶聚合物晶体体中的受控对称性破缺
  • 批准号:
    2104968
  • 财政年份:
    2021
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Multifunctional solid polymer electrolytes for all-solid-state batteries
全固态电池用多功能固体聚合物电解质
  • 批准号:
    2033882
  • 财政年份:
    2020
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Multifunctional 2D Polymers and Hybrids via Crystal Engineering
通过晶体工程实现多功能二维聚合物和杂化物
  • 批准号:
    1762626
  • 财政年份:
    2018
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Confined and Directed Polymer Crystallization at Curved Liquid/Liquid Interface
弯曲液/液界面处的限域定向聚合物结晶
  • 批准号:
    1709136
  • 财政年份:
    2017
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Collaborative Research: Polymer Single Crystal-Assisted "Grafting From": A Versatile Approach towards Multicomponent Polymer Brushes with Well-Defined Architectures and Grafting
合作研究:聚合物单晶辅助“接枝”:具有明确结构和接枝的多组分聚合物刷的多功能方法
  • 批准号:
    1709119
  • 财政年份:
    2017
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
SusChEM: Hybrid and Double Network Solid Polymer Electrolytes
SusChEM:混合和双网络固体聚合物电解质
  • 批准号:
    1603520
  • 财政年份:
    2016
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
UNS: Ion transport in semicrystalline solid polymer electrolytes
UNS:半结晶固体聚合物电解质中的离子传输
  • 批准号:
    1510092
  • 财政年份:
    2015
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Self and Programmable Assembly of Nanoparticles with Multicompartment Polymer Brushes
使用多室聚合物刷进行纳米颗粒的自组装和可编程组装
  • 批准号:
    1438240
  • 财政年份:
    2014
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Polymer Crystallization at Curved Liquid/Liquid Interface
弯曲液/液界面处的聚合物结晶
  • 批准号:
    1308958
  • 财政年份:
    2013
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant

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