I-Corps: Lignin-derived antimicrobials to control bacterial contamination in fuel ethanol fermentation

I-Corps:木质素衍生抗菌剂可控制燃料乙醇发酵中的细菌污染

基本信息

  • 批准号:
    2105899
  • 负责人:
  • 金额:
    $ 5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-02-01 至 2023-04-30
  • 项目状态:
    已结题

项目摘要

The broader impact/commercial potential of this I-Corps project is the development of a sustainable antibiotic replacement, produced from a known waste stream (lignin), for use during fuel ethanol fermentation. In the fuel ethanol industry, traditional antibiotics, such as virginiamycin or penicillin, are introduced prophylactically into the fermentation process to reduce occurrences of bacterial contamination. However, widespread use of such antibiotics has increased the emergence of antibiotic-resistant microorganisms that pose an ever-growing risk to human health and the environment. Additionally, these antibiotics have been shown to persist in downstream coproducts such as distillers’ grains, which is becoming a major concern for consumers of livestock that are fed the byproduct. Therefore, the production of novel antimicrobial agents with similar selective toxicity, better biodegradability, and effectiveness against antibiotic-resistant bacterial strains would be highly marketable and useful in industrial yeast fermentation environments. If commercialized successfully, the proposed innovation may offer industrial consumers a sustainably derived antibiotic product to combat contamination during fermentation without the pitfalls of traditional antibiotics. In addition, valorization of lignin waste streams for value-added products may allow future lignocellulosic-based biorefineries to be more cost-effective.This I-Corps project is based on the development of an antibiotic replacement produced from lignin waste streams. Lignin is one of the most abundant natural phenolic polymers on earth, plays an important role in plants’ natural defense mechanisms, and is currently considered a major waste product in the paper and pulp industries and lignocellulosic biorefineries. Despite the widely reported antioxidant and antimicrobial properties, lignin-derived antimicrobials have poor selectivity thus limiting their real-world applications. The proposed technology offers a potential solution by converting lignin into a cost-effective and biodegradable antimicrobial product that may selectively inhibit bacterial contaminates and increase ethanol yields during fuel ethanol fermentation. By oxidatively depolymerizing lignin into a liquid product under mild reaction conditions, the resulting product has shown selective antimicrobial properties against lactic acid bacteria, including antibiotic resistant strains, without affecting yeast growth and hydrolase activity. Proof of concept has been demonstrated at the lab scale, but further development of the technology demands a better understanding of the potential customer needs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个i-Corps项目的更广泛的影响/商业潜力是开发一种可持续的抗生素替代品,从已知的废液(木质素)中生产,用于燃料乙醇发酵。在燃料乙醇行业,传统的抗生素,如维吉尼亚霉素或青霉素,被预防性地引入发酵过程,以减少细菌污染的发生。然而,这类抗生素的广泛使用增加了抗药性微生物的出现,对人类健康和环境构成了越来越大的风险。此外,这些抗生素已被证明在下游的副产品中持续存在,如酒糟,这正成为喂养副产品的牲畜消费者的主要担忧。因此,生产具有相似选择毒性、更好的生物降解性和对抗生素耐药菌株有效的新型抗菌剂在工业酵母发酵环境中具有很高的市场和实用价值。如果成功商业化,拟议中的创新可能会为工业消费者提供一种可持续衍生的抗生素产品,以对抗发酵过程中的污染,而不会出现传统抗生素的陷阱。此外,木质素废液用于增值产品的价格化可能会使未来基于木质纤维的生物精炼更具成本效益。这个i-Corps项目是基于开发利用木质素废液生产的抗生素替代品。木质素是地球上含量最丰富的天然酚类聚合物之一,在植物的自然防御机制中发挥着重要作用,目前被认为是造纸和纸浆工业以及木质纤维生物炼油厂的主要废物。尽管木质素具有广泛的抗氧化剂和抗菌性能,但木质素衍生的抗菌剂选择性较差,从而限制了其在现实世界中的应用。这项拟议的技术提供了一种潜在的解决方案,将木质素转化为一种成本效益高的可生物降解的抗菌产品,在燃料乙醇发酵过程中可以选择性地抑制细菌污染并增加乙醇产量。通过在温和的反应条件下将木质素氧化解聚为液体产物,生成的产物对乳酸菌(包括耐药菌株)表现出选择性的抗菌性能,而不影响酵母生长和水解酶活性。概念证明已经在实验室规模上得到了证明,但技术的进一步发展需要更好地了解潜在的客户需求。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

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Jian Shi其他文献

Prioritizing gene cascading paths to model colorectal cancer through engineered organoids
通过工程类器官优先考虑基因级联路径来模拟结直肠癌
  • DOI:
    10.3389/fbioe.2020.00012
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    Yanyan Ping;Chaohan Xu;Liwen Xu;Gaoming Liao;Chunyu Deng;Yujia Lan;Fulong Yu;Jian Shi;Li Wang;Yun Xiao;Xia Li
  • 通讯作者:
    Xia Li
A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina.
阿司匹林加替罗非班与阿司匹林加肝素治疗不稳定心绞痛的比较。
  • DOI:
  • 发表时间:
    1998
  • 期刊:
  • 影响因子:
    158.5
  • 作者:
    Ceng Chen;Jian Shi;Yadong Guo;Lagabaiyla Zha;L. Lan;Yunfeng Chang;Yanjun Ding
  • 通讯作者:
    Yanjun Ding
Biogeochemical transformation processes of iron, manganese, ammonium under coexisting conditions in groundwater based on experimental data
基于实验数据的地下水共存条件下铁、锰、铵的生物地球化学转化过程
  • DOI:
    10.1016/j.jhydrol.2021.127120
  • 发表时间:
    2021-12
  • 期刊:
  • 影响因子:
    6.4
  • 作者:
    Rui Zuo;Minghao Pan;Jian Li;Li Meng;Jie Yang;Yuanzheng Zhai;Zhenkun Xue;Jiawei Liu;Jian Shi;Yanguo Teng
  • 通讯作者:
    Yanguo Teng
Isolating - a new resampling method for gene order data
分离——一种新的基因顺序数据重采样方法
Motion Controller for Atomic Force Microscopy Based Nanobiomanipulation
基于原子力显微镜的纳米生物操作运动控制器
  • DOI:
    10.1007/978-3-642-22173-6_9
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    N. Xi;Ruiguo Yang;K. Lai;Bo Song;Bingtuan Gao;Jian Shi;C. Su
  • 通讯作者:
    C. Su

Jian Shi的其他文献

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{{ truncateString('Jian Shi', 18)}}的其他基金

CAS-Climate: CAREER: A Unified Zero-Carbon-Driven Design Framework for Accelerating Power Grid Deep Decarbonization (ZERO-ACCELERATOR)
CAS-气候:职业:加速电网深度脱碳的统一零碳驱动设计框架(零加速器)
  • 批准号:
    2338158
  • 财政年份:
    2024
  • 资助金额:
    $ 5万
  • 项目类别:
    Continuing Grant
Chiral Strain Engineering of Polar Semiconductors
极性半导体的手性应变工程
  • 批准号:
    2312944
  • 财政年份:
    2023
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
Switchable Persistent Spin Helix Devices
可切换的持续自旋螺旋装置
  • 批准号:
    2314614
  • 财政年份:
    2023
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
Symmetry-protected spin dynamics in ferroelectric spin device
铁电自旋器件中对称保护的自旋动力学
  • 批准号:
    2031692
  • 财政年份:
    2020
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
Scalable Manufacturing of Single Crystalline Halide Perovskite Film via Interface Engineering
通过界面工程大规模制造单晶卤化物钙钛矿薄膜
  • 批准号:
    2024972
  • 财政年份:
    2020
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
Van der Waals Halide Perovskite Photo-ferroelectric Synapse
范德华卤化物钙钛矿光铁电突触
  • 批准号:
    1916652
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
RII Track-4: Elucidating Enzyme-Ionic Liquid Interactions to Enable Effective Lignin Valorization
RII Track-4:阐明酶-离子液体相互作用以实现有效的木质素增值
  • 批准号:
    1929122
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
SusChEM: Exploring Chalcohalide Split-Anion Perovskite Photovoltaics Materials
SusChEM:探索硫卤化物分裂阴离子钙钛矿光伏材料
  • 批准号:
    1706815
  • 财政年份:
    2017
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
HOD: Handling missing data and time-varying confounding in causal inference for observational event history data
HOD:处理观测事件历史数据因果推断中的缺失数据和时变混杂
  • 批准号:
    MR/M025152/2
  • 财政年份:
    2017
  • 资助金额:
    $ 5万
  • 项目类别:
    Research Grant
Modification of Soft Inorganic Thin Films through the use of van der Waals Epitaxial Strain
通过使用范德华外延应变对软无机薄膜进行改性
  • 批准号:
    1635520
  • 财政年份:
    2016
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant

相似国自然基金

“Lignin-first”策略下镁碱催化原生木质素定向氧化为小分子有机酸的机制研究
  • 批准号:
    21908075
  • 批准年份:
    2019
  • 资助金额:
    25.0 万元
  • 项目类别:
    青年科学基金项目

相似海外基金

Preparation of high-performance biomass-derived resins by simultaneous conduction of lignin separation and phenolic OH group increase
同时进行木质素分离和酚羟基增加制备高性能生物质树脂
  • 批准号:
    23H03574
  • 财政年份:
    2023
  • 资助金额:
    $ 5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of Sustainable Circulating Polymer from Lignin Derived Molecules
利用木质素衍生分子开发可持续循环聚合物
  • 批准号:
    22H02121
  • 财政年份:
    2022
  • 资助金额:
    $ 5万
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Understanding the effect of lignin chemistry on the graphitic structure of lignin derived carbon fibres
了解木质素化学对木质素衍生碳纤维石墨结构的影响
  • 批准号:
    2756690
  • 财政年份:
    2022
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    $ 5万
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Understanding the role of lignin types in plant-derived methane
了解木质素类型在植物源甲烷中的作用
  • 批准号:
    561396-2021
  • 财政年份:
    2021
  • 资助金额:
    $ 5万
  • 项目类别:
    University Undergraduate Student Research Awards
Bacterial siderophore production from lignin derived compounds
从木质素衍生化合物生产细菌铁载体
  • 批准号:
    565859-2021
  • 财政年份:
    2021
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    $ 5万
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    Alexander Graham Bell Canada Graduate Scholarships - Master's
Collaborative Research: Identification of Lignin-derived Ligands Associating With Iron
合作研究:鉴定与铁结合的木质素衍生配体
  • 批准号:
    2108270
  • 财政年份:
    2021
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
Collaborative Research: Identification of Lignin-derived Ligands Associating With Iron
合作研究:鉴定与铁结合的木质素衍生配体
  • 批准号:
    2108340
  • 财政年份:
    2021
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    $ 5万
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    Standard Grant
Probing the behaviour of lignin derived monomers in catalytic zeolite systems
探讨木质素衍生单体在催化沸石系统中的行为
  • 批准号:
    2436270
  • 财政年份:
    2020
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CAS: Polymers from biomass using monomers derived from lignin
CAS:使用木质素单体制成的生物质聚合物
  • 批准号:
    2003863
  • 财政年份:
    2020
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
Transformation of lignin-derived aromatics in wood biomass into nonaromatic polymeric substances with fluorescent activities
将木材生物质中木质素衍生的芳香族化合物转化为具有荧光活性的非芳香族聚合物
  • 批准号:
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    2020
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    $ 5万
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