Sustaining the operation of the Peromyscus Genetic Stock Center

维持白鼠遗传资源中心的运作

• 批准号: 2105999
• 负责人: Hippokratis Kiaris
• 金额: $ 48.71万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2105999&HistoricalAwards=false
• 关键词: Sustaining; operation; Peromyscus; Genetic; Stock

Deer mice (Genus Peromyscus) are the most abundant rodents in North America and are used extensively by investigators in the USA and all over the world for research in disciplines ranging from ecology and evolution, to genetics, physiology, public health and infectious diseases. Besides academic investigators, Peromyscus users also include other federal agencies in the U.S. as well as private entities. The Peromyscus Genetic Stock Center (PGSC) of the University of South Carolina maintains and distributes for a small fee, to interested investigators, animals of 5 different species of Peromyscus that are maintained in its facilities for more than 40 years as closed colonies. In addition to the animals, the PGSC also provides upon request pedigree data and performs small scale experiments. In addition, it operates as a focal point for the dissemination of information related to Peromyscus biology. Finally, it actively trains investigators of all different levels, from students to senior faculty, in Peromyscus-related biology. The current award assists in the uninterrupted operation of the PGSC. The mission of the Peromyscus Genetic Stock Center (PGSC) is to maintain colonies of various species of outbred, genetically diverse deer mice (genus Peromyscus) and distribute them to investigators in the US and all over the world. Currently the PGSC maintains six different closed colonies, involving 5 Peromyscus species: P. maniculatus (2 colonies), P. polionotus, P. eremicus, P. californicus, and P. leucopus. For all animals generated in the PGSC, pedigree data since the original establishment of the colonies are available to external users. In addition, specific small- scale experimental tasks are being performed upon request and are provided as “contract research” operations. The continuous and uninterrupted operation of the PGSC satisfy a series of specific needs to the community of Peromyscus-interested investigators. Those include but not limited to: availability of animals of given quality and genetic make-up from “reference”, wild type populations; availability of pedigree data that allow tracing back each animal generated (and supplied to outside users) in the PGSC to the original ancestors from when the colony was established; the existence of a focal point for Peromyscus-associated research which accumulates and disseminates information to the communities of interest. The PGSC also serves as a training point which investigators visit and receive training on Peromyscus handling and colony maintenance.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

鹿鼠（鹿鼠属）是北美最丰富的啮齿动物，被美国和世界各地的研究人员广泛用于生态学和进化、遗传学、生理学、公共卫生和传染病等学科的研究。除了学术调查人员，Peromyscus的用户还包括美国其他联邦机构以及私人实体。南卡罗来纳大学的高omyscus遗传资源中心（PGSC）为感兴趣的研究人员维护并分发了5种不同的高omyscus动物，这些动物作为封闭的群体在其设施中保存了40多年。除了动物外，PGSC还应要求提供系谱数据并进行小规模实验。此外，它还作为传播有关Peromyscus生物学信息的焦点。最后，它积极培训从学生到高级教师的各个层次的研究人员，研究与石原菌有关的生物学。目前的奖项有助于PGSC的不间断运作。Peromyscus遗传资源中心（PGSC）的任务是维护各种近亲繁殖，遗传多样化的鹿鼠（Peromyscus属）的殖民地，并将它们分发给美国和世界各地的研究人员。目前，PGSC维持着6个不同的封闭菌落，涉及5种Peromyscus: P. maniculatus（2个菌落）、P. polionotus、P. eremicus、P. californicus和P. leucopus。对于在PGSC中产生的所有动物，自最初建立菌落以来的系谱数据可供外部用户使用。此外，还应要求进行特定的小规模实验任务，并作为“合同研究”业务提供。PGSC的连续和不间断的运行满足了对peromyscus感兴趣的研究人员社区的一系列特定需求。这些包括但不限于：从“参考”野生型种群中获得具有一定质量和基因构成的动物；谱系数据的可用性，可以追溯到PGSC中产生的每只动物（并提供给外部用户）的原始祖先，从殖民地建立时开始；有一个聚焦点的存在，聚焦点可以积累和传播相关的信息。PGSC还作为一个培训点，调查人员访问并接受关于处理和菌落维护的培训。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。