Sustaining the operation of the Peromyscus Genetic Stock Center

鹿鼠(Permyscus)是北美数量最多的啮齿动物，被美国和世界各地的研究人员广泛用于从生态学和进化论到遗传学、生理学、公共卫生和传染病的研究。除了学术研究人员，Permyscus的用户还包括美国的其他联邦机构以及私人实体。南卡罗来纳大学Permyscus Genetic Stock Center(PGSC)以一小笔费用维护并分发给感兴趣的研究人员，这些动物来自5个不同物种的Permyscus，作为封闭殖民地在其设施中饲养了40多年。除了动物外，PGSC还应要求提供谱系数据并进行小规模实验。此外，它还作为传播与Permyscus生物学有关的信息的中心。最后，它积极培训所有不同层次的研究人员，从学生到高级教职员工，学习与Permyscus相关的生物学。目前的奖项有助于PGSC的不间断运作。Permyscus Genetic Stock Center(PGSC)的任务是维护不同物种的近交鹿小鼠(Permyscus属)的群体，并将它们分发给美国和世界各地的研究人员。目前，PGSC维持着6个不同的封闭群体，涉及5个Permyscus物种：P.manulatus(2个群体)、P.Polonotus、P.eremicus、P.calforNicus和P.leucopus。对于在PGSC中产生的所有动物，自最初建立殖民地以来的系谱数据对外部用户可用。此外，具体的小规模实验任务正在按要求进行，并作为“合同研究”业务提供。PGSC的连续和不间断运行满足了对Permyscus感兴趣的研究人员的一系列特殊需求。这些问题包括但不限于：提供来自“参考”野生类型种群的给定质量和遗传组成的动物；提供系谱数据，追溯PGSC中产生(并提供给外部用户)的每一种动物，追溯到该殖民地建立时的原始祖先；存在一个与Permyscus相关的研究中心，该中心积累信息并将信息传播给相关社区。PGSC也是研究人员访问和接受关于Permyscus处理和种群维护的培训的训练点。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

Deer mice (Genus Peromyscus) are the most abundant rodents in North America and are used extensively by investigators in the USA and all over the world for research in disciplines ranging from ecology and evolution, to genetics, physiology, public health and infectious diseases. Besides academic investigators, Peromyscus users also include other federal agencies in the U.S. as well as private entities. The Peromyscus Genetic Stock Center (PGSC) of the University of South Carolina maintains and distributes for a small fee, to interested investigators, animals of 5 different species of Peromyscus that are maintained in its facilities for more than 40 years as closed colonies. In addition to the animals, the PGSC also provides upon request pedigree data and performs small scale experiments. In addition, it operates as a focal point for the dissemination of information related to Peromyscus biology. Finally, it actively trains investigators of all different levels, from students to senior faculty, in Peromyscus-related biology. The current award assists in the uninterrupted operation of the PGSC. The mission of the Peromyscus Genetic Stock Center (PGSC) is to maintain colonies of various species of outbred, genetically diverse deer mice (genus Peromyscus) and distribute them to investigators in the US and all over the world. Currently the PGSC maintains six different closed colonies, involving 5 Peromyscus species: P. maniculatus (2 colonies), P. polionotus, P. eremicus, P. californicus, and P. leucopus. For all animals generated in the PGSC, pedigree data since the original establishment of the colonies are available to external users. In addition, specific small- scale experimental tasks are being performed upon request and are provided as “contract research” operations. The continuous and uninterrupted operation of the PGSC satisfy a series of specific needs to the community of Peromyscus-interested investigators. Those include but not limited to: availability of animals of given quality and genetic make-up from “reference”, wild type populations; availability of pedigree data that allow tracing back each animal generated (and supplied to outside users) in the PGSC to the original ancestors from when the colony was established; the existence of a focal point for Peromyscus-associated research which accumulates and disseminates information to the communities of interest. The PGSC also serves as a training point which investigators visit and receive training on Peromyscus handling and colony maintenance.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.