CSBR: Living Stocks Support for the Peromyscus Genetic Stock Center

授予南卡罗来纳州大学一个奖项，为Peromyscus遗传储备中心（PGSC）提供支持。鹿鼠属动物（通常称为鹿鼠、白色足鼠、海滩鼠等）是NSF支持的和其他研究进化，适应和应激反应，行为，生理学，宿主-寄生虫相互作用，微生物组相关研究等研究人员的首选模型。PGSC维持和分发鹿鼠的远交种。此外，它还提供各种物种的生物样本，如新鲜、冷冻和保存的组织、DNA、粪便和血液样本，并应外部要求开展小规模研究项目，以满足外部调查人员的研究需要。鉴于科学对透明度和可重复性的持续需求，PGSC提供了一个稳定和不间断的动物供应，这些动物具有经过验证的质量，健康，遗传和生理状态。PGSC也是Peromyscus相关研究的中心，并为本科生和研究生以及其他使用Peromyscus进行研究的研究人员提供培训。鹿鼠Peromyscus maniculatus和同类物种是最常见的北美本土哺乳动物。 它们分布在阿拉斯加到中美洲的许多自然栖息地。由于其丰富的，这些动物构成了近地陆地生态系统的主要组成部分。 PGSC保持从鹿鼠属鹿鼠野生种群中存在的地理变异中提取的遗传和表型变异。这些股票提供了重要的资源，研究基因型表型的关系，当地的适应和自然种群的进化。 自然选择和适应的一些最明确的证据来自对鹿鼠的研究。 Peromyscus已经成为研究主要生物过程的首选模型，如物种形成，适应和应激反应，生理学和进化背景下的行为适应，宿主-寄生虫相互作用，微生物组相关研究等。 该中心通过提供活体种群进行定量遗传和基因组分析，以确定生态重要性，适应性表型变异的基因，并预测空间变化和时间变化环境中的种群进化反应，从而实现这些研究。 Peromyscus Genetic Stock Center（PGSC）维护和分发Peromyscus的远交种和几种行为和毛色突变体用于研究。 此外，它还向调查人员提供各种物种的生物样本，如新鲜、冷冻和保存的组织、DNA、粪便和血液样本，并应外部要求开展小规模研究项目，以满足调查人员的研究需要。PGSC还通过每年出版两次的时事通讯“Perotimes”和PGSC网站（www.pgsc.cas.sc.edu）作为Peromyscus相关信息的交换所。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to the University of South Carolina to provide support for the Peromyscus Genetic Stock Center (PGSC). Animals of the genus Peromyscus (commonly referred to as deer mice, white footed mice, beach mice, etc.) are a model of choice for NSF-supported and other investigators that study evolution, adaptation and stress response, behavior, physiology, host-parasite interactions, microbiome-associated studies and others. The PGSC maintains and distributes outbred stocks of Peromyscus. In addition, it provides biological samples of various species, such as fresh, frozen and preserved tissues, DNA, fecal and blood samples and in response to external requests performs small-scale research projects to facilitate the research needs of external investigators. In view of the continuing need for transparency and reproducibility in science, the PGSC provides a consistent and uninterrupted supply of animals with verified quality, health, genetic and physiological status. The PGSC also operates as a focal point for Peromyscus associated research and provides training for undergraduate and graduate students, and other investigators using Peromyscus in research.The deer mouse Peromyscus maniculatus and congeneric species are the most common native North American mammal. They range from Alaska to Central America and occur in many natural habitats. Because of their abundance, these animals constitute a major component of nearctic terrestrial ecosystems. The PGSC maintains genetic and phenotypic variants drawn from the geographic variation present in wild populations of deer mice in the genus Peromyscus. These stocks provide critical resources for the study of genotype to phenotype relationships, local adaptation, and evolution in natural populations. Some of the clearest evidence of natural selection and adaptation have come from studies of deer mice. Peromyscus has emerged a model of choice for the study of major biological processes such as speciation, adaptation and stress response, behavior adaptation in the context of physiology and evolution, host-parasite interactions, microbiome-associated studies and others. The stock center enables these studies by providing living stocks for quantitative genetic and genomic analyses to identify the genes underlying ecologically important, adaptive phenotypic variation and make predictions about population evolutionary response in a spatially variable and temporally changing environment. The Peromyscus Genetic Stock Center (PGSC) maintains and distributes outbred stocks of Peromyscus and several behavioral and coat-color mutants for research. In addition, it provides investigators with biological samples of various species, such as fresh, frozen and preserved tissues, DNA, fecal and blood samples and in response to external requests performs small-scale research projects to facilitate investigator's research needs. The PGSC also functions as a clearing-house for Peromyscus associated information through the 'Perotimes', a newsletter that is published twice a year, and the PGSC website (www.pgsc.cas.sc.edu).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.