CSBR: Living Stocks Support for the Peromyscus Genetic Stock Center

CSBR：为白鼠遗传种群中心提供活体种群支持

• 批准号: 1755670
• 负责人: Hippokratis Kiaris
• 金额: $ 49.92万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1755670&HistoricalAwards=false
• 关键词: CSBR; Living; Stocks; Support; Peromyscus

An award is made to the University of South Carolina to provide support for the Peromyscus Genetic Stock Center (PGSC). Animals of the genus Peromyscus (commonly referred to as deer mice, white footed mice, beach mice, etc.) are a model of choice for NSF-supported and other investigators that study evolution, adaptation and stress response, behavior, physiology, host-parasite interactions, microbiome-associated studies and others. The PGSC maintains and distributes outbred stocks of Peromyscus. In addition, it provides biological samples of various species, such as fresh, frozen and preserved tissues, DNA, fecal and blood samples and in response to external requests performs small-scale research projects to facilitate the research needs of external investigators. In view of the continuing need for transparency and reproducibility in science, the PGSC provides a consistent and uninterrupted supply of animals with verified quality, health, genetic and physiological status. The PGSC also operates as a focal point for Peromyscus associated research and provides training for undergraduate and graduate students, and other investigators using Peromyscus in research.The deer mouse Peromyscus maniculatus and congeneric species are the most common native North American mammal. They range from Alaska to Central America and occur in many natural habitats. Because of their abundance, these animals constitute a major component of nearctic terrestrial ecosystems. The PGSC maintains genetic and phenotypic variants drawn from the geographic variation present in wild populations of deer mice in the genus Peromyscus. These stocks provide critical resources for the study of genotype to phenotype relationships, local adaptation, and evolution in natural populations. Some of the clearest evidence of natural selection and adaptation have come from studies of deer mice. Peromyscus has emerged a model of choice for the study of major biological processes such as speciation, adaptation and stress response, behavior adaptation in the context of physiology and evolution, host-parasite interactions, microbiome-associated studies and others. The stock center enables these studies by providing living stocks for quantitative genetic and genomic analyses to identify the genes underlying ecologically important, adaptive phenotypic variation and make predictions about population evolutionary response in a spatially variable and temporally changing environment. The Peromyscus Genetic Stock Center (PGSC) maintains and distributes outbred stocks of Peromyscus and several behavioral and coat-color mutants for research. In addition, it provides investigators with biological samples of various species, such as fresh, frozen and preserved tissues, DNA, fecal and blood samples and in response to external requests performs small-scale research projects to facilitate investigator's research needs. The PGSC also functions as a clearing-house for Peromyscus associated information through the 'Perotimes', a newsletter that is published twice a year, and the PGSC website (www.pgsc.cas.sc.edu).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

南卡罗来纳大学获得了一项奖励，为Peromyscus遗传资源中心（PGSC）提供支持。Peromyscus属动物（通常被称为鹿鼠、白足鼠、沙滩鼠等）是nsf支持的研究人员和其他研究人员研究进化、适应和应激反应、行为、生理学、宿主-寄生虫相互作用、微生物组相关研究等的首选模型。PGSC维持和分发远交种的佩罗米斯鱼。此外，它还提供各种物种的生物样本，如新鲜、冷冻和保存的组织、DNA、粪便和血液样本，并应外部要求进行小规模研究项目，以便利外部调查人员的研究需要。鉴于科学方面对透明度和可重复性的持续需求，PGSC持续和不间断地提供质量、健康、遗传和生理状况经过验证的动物。PGSC还作为Peromyscus相关研究的焦点，并为本科生和研究生以及在研究中使用Peromyscus的其他研究人员提供培训。鹿鼠（Peromyscus maniculatus）及其同属种是北美最常见的本土哺乳动物。它们分布在从阿拉斯加到中美洲的许多自然栖息地。由于数量众多，这些动物构成了新北极陆地生态系统的主要组成部分。PGSC维持了从野生鹿鼠种群中存在的地理变异中得出的遗传和表型变异。这些种群为研究自然种群的基因型与表型关系、局部适应和进化提供了重要资源。一些关于自然选择和适应的最清晰证据来自对鹿鼠的研究。Peromyscus已成为研究主要生物过程的首选模型，如物种形成、适应和应激反应、生理和进化背景下的行为适应、宿主-寄生虫相互作用、微生物组相关研究等。种群中心通过提供活体种群进行定量遗传和基因组分析，以确定生态上重要的基因，适应性表型变异，并预测种群在空间变量和时间变化环境中的进化反应，从而使这些研究成为可能。Peromyscus遗传资源中心（PGSC）维护和分发Peromyscus的近交资源和一些行为和毛色突变体用于研究。此外，它还为调查人员提供各种物种的生物样本，如新鲜、冷冻和保存的组织、DNA、粪便和血液样本，并应外部要求执行小规模研究项目，以促进调查人员的研究需求。PGSC还通过每年出版两次的“Perotimes”通讯和PGSC网站（www.pgsc.cas.sc.edu）作为Peromyscus相关信息的交流中心。该奖项反映了NSF的法定使命，并通过基金会的知识价值和更广泛的影响审查标准进行了评估，认为值得支持。

项目成果

Support for Living Stock Collections: A Mammalian Stock Center Perspective

对活体种群收藏的支持：哺乳动物种群中心的视角

• DOI: 10.1016/j.tig.2018.12.001
• 发表时间: 2018
• 期刊: Trends in Genetics
• 影响因子: 11.4
• 作者: Kiaris, Hippokratis

Coordination in the unfolded protein response during aging in outbred deer mice

• DOI: 10.1016/j.exger.2020.111191
• 发表时间: 2021-02-01
• 期刊: EXPERIMENTAL GERONTOLOGY
• 影响因子: 3.9
• 作者: Soltanmohammadi, E.;Farmaki, E.;Kiaris, H.
• 通讯作者: Kiaris, H.