Research Infrastructure: Peromyscus Genetic Stock Center Support

鹿鼠（Peromyscus）是北美最丰富的啮齿动物，被世界各地的研究人员广泛用于生态学和进化，遗传学，生理学，公共卫生和传染病等学科的研究。除了学术研究人员，Peromyscus的用户还包括美国的其他联邦机构和私人实体。南卡罗来纳州大学的Peromyscus Genetic Stock Center（PGSC）保存并分发5种不同种类的Peromyscus动物。该奖项的支持将有助于PGSC的不间断运营。PGCS的使命是维持各种远交、遗传多样性鹿鼠（鹿鼠属）的群落，并将其分发给美国和世界各地的研究人员。目前维持了6个不同的封闭菌落，涉及5种鹿鼠属：P. maniculatus（2个菌落）、P. polionotus、P. eremicus、P. californicus和P. leucopus。对于PGSC中生成的所有动物，外部用户可获得自最初建立菌落以来的谱系数据。纯种动物的可用性，包括来自“参考”野生型种群的动物，对研究的再现性特别重要。 此外，可以根据要求执行特定的小规模实验任务，并作为合同研究操作提供（例如，DNA取样、组织学分析、特殊饮食、卵巢切除术或输精管切除术）。PGSC还作为Peromyscus相关研究的联络点，积累和传播信息给感兴趣的社区，并为访问调查人员提供培训，以处理Peromyscus和菌落维护。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。

Deer mice (Genus Peromyscus) are the most abundant rodents in North America and are used extensively by investigators all over the world for research in disciplines ranging from ecology and evolution, to genetics, physiology, public health and infectious diseases. Besides academic investigators, Peromyscus users also include other federal agencies in the U.S. and private entities. The Peromyscus Genetic Stock Center (PGSC) of the University of South Carolina maintains and distributes animals of 5 different species of Peromyscus. Support from this award will assist in the uninterrupted operation of the PGSC.The mission of the PGCS is to maintain colonies of various species of outbred, genetically diverse deer mice (genus Peromyscus) and distribute them to investigators in the US and all over the world. Six different closed colonies are currently maintained, involving 5 Peromyscus species: P. maniculatus (2 colonies), P. polionotus, P. eremicus, P. californicus, and P. leucopus. For all animals generated in the PGSC, pedigree data since the original establishment of the colonies are available to external users. The availability of pedigreed animals, including animals from "reference" wild type populations, is of particular significance for research reproducibility. In addition, specific small-scale experimental tasks can be performed upon request and are provided as contract research operations (e.g., DNA sampling, histologic analyses, special diets, ovariectomy, or vasectomy procedures). The PGSC also serves as a focal point for Peromyscus-associated research to accumulates and disseminate information to the communities of interest and provides training for visiting investigators on Peromyscus handling and colony maintenance.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.