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Self-Assembled Multicomponent Ligands for Allosteric Catalysis

用于变构催化的自组装多组分配体

基本信息

批准号：
1506221
负责人：
Michael Pluth
金额：
$ 49.47万
依托单位：
University of Oregon Eugene
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1506221&HistoricalAwards=false
关键词：
Self Assembled Multicomponent Ligands Allosteric

项目摘要

Many chemical transformations rely on catalysts to enhance the rate of a reaction or to favor formation of a desired product over an undesired product. The manufacturing costs of chemicals, polymers, and materials can be significantly reduced by employing efficient catalytic processes. A significant challenge in designing new catalysts, however, is that many catalysts have complicated structures and are difficult to synthesize. The Macromolecular, Supramolecular and Nanochemistry Program of the Division of Chemistry supports Professor Michael Pluth of the University of Oregon to develop novel approaches to preparing catalysts of complex structures via self-assembly of simple subunits and to investigate how the activities of these catalysts can be modulated. This research aims to provide new insights into how catalysts can be activated or deactivated on-demand. Complementing the scientific goals of this research, the project helps to prepare a workforce for industry and academia by providing research training to graduate students. It also promotes STEM education by facilitating research experiences for undergraduate students and by expanding outreach activities with local middle- and high schools.Prof. Pluth's research group designs and synthesizes ligands that can self-assemble into active catalysts after binding a "guest" molecule. His research aims to provide new basic knowledge on how guest molecules can transmit information to the catalyst upon binding and enable allosteric regulation of supramolecular catalysis. Of particular interest is the investigation of chirality transfer between guest and host to uncover new insights into chiral induction through non-covalent interactions. To demonstrate chirality transfer between guest and the catalyst, his research group uses chiral guests as chiral co-factors to enable enantioselective self-assembled catalysts and studies the impact of binding on the rate and selectivity of platinum- and rhodium-catalyzed hydroformylation reactions.

许多化学转化依赖于催化剂来提高反应速率或有利于形成期望的产物而不是不期望的产物。化学品、聚合物和材料的制造成本可以通过采用有效的催化工艺来显著降低。然而，设计新催化剂的一个重大挑战是许多催化剂具有复杂的结构并且难以合成。化学系的大分子、超分子和纳米化学项目支持俄勒冈州大学的Michael Pluth教授开发新方法，通过简单亚基的自组装制备复杂结构的催化剂，并研究如何调节这些催化剂的活性。这项研究旨在为催化剂如何按需激活或失活提供新的见解。该项目补充了这项研究的科学目标，通过为研究生提供研究培训，帮助为工业和学术界准备一支劳动力队伍。此外，通过为本科生提供研究体验，以及扩大与当地初中和高中的外联活动，促进STEM教育。Pluth教授的研究小组设计并合成了能够在与“客体”分子结合后自组装成活性催化剂的配体。他的研究旨在提供关于客体分子如何在结合时将信息传递给催化剂并使超分子催化的变构调节成为可能的新的基础知识。特别感兴趣的是客体和主体之间的手性转移的调查，揭示通过非共价相互作用的手性诱导的新见解。为了证明客体和催化剂之间的手性转移，他的研究小组使用手性客体作为手性辅因子来实现对映选择性自组装催化剂，并研究了结合对铂和铑催化加氢反应的速率和选择性的影响。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Potentiometric measurement of barbituric acid by integration of supramolecular receptors into ChemFETs

DOI：
10.1016/j.sbsr.2021.100397
发表时间：
2021-01-30
期刊：
SENSING AND BIO-SENSING RESEARCH
影响因子：
5.3
作者：
Kuhl, Grace M.;Seidenkranz, Daniel T.;Fontenot, Sean A.
通讯作者：
Fontenot, Sean A.

Learning from Our Mistakes: We Have a Scientific and Fiscal Obligation to Publish Failed Results

从错误中吸取教训：我们有科学和财政义务公布失败的结果

DOI：
10.26434/chemrxiv.13141283.v1
发表时间：
2020
期刊：
ChemRxiv
影响因子：
0
作者：
Levinn, C.;Pluth, M
通讯作者：
Pluth, M

Supramolecular bidentate phosphine ligand scaffolds from deconstructed Hamilton receptors

来自解构的汉密尔顿受体的超分子二齿膦配体支架

DOI：
10.1039/c6cc09198a
发表时间：
2017
期刊：
Chemical Communications
影响因子：
4.9
作者：
Seidenkranz, Daniel T.;McGrath, Jacqueline M.;Zakharov, Lev N.;Pluth, Michael D.
通讯作者：
Pluth, Michael D.