MRI: Acquisition of a High Resolution Mass Spectrometer for Research and Education at a University of Oregon Facility

在主要研究仪器计划（MRI）的这一奖项和化学研究仪器计划（CRIF）的支持下，来自俄勒冈州尤金大学的Michael Pluth教授和同事Ramesh Jasti获得了具有电喷雾电离（ESI）和超高效液相色谱（UPLC）功能的高分辨率液相色谱质谱仪（LCMS）。该仪器放置在俄勒冈州大学的开放访问CAMCOR（俄勒冈州先进材料和表征中心）设施中。 一般来说，质谱（MS）是用于识别和表征复杂混合物中嵌入的少量化学物质的关键分析方法之一。这种高灵敏度的技术可以检测和确定复杂混合物中分子的结构。带有液相色谱仪的仪器通过在化合物到达质谱仪之前分离化合物的混合物来提供额外的结构鉴定能力。在ESI源中，将高电压施加到液体以产生促进离子产生的气溶胶。此次收购加强了大学和地区的研究基础设施。该工具还通过利用这一现代分析技术让不同的学生参与研究和研究培训来扩大参与。它还通过各种实习计划为大量本科生，研究生和博士后学生以及高中生提供培训机会。CAMCOR的新功能为学术和工业用户提供了巨大的机会。该提案旨在加强各级的研究和教育，特别是在以下领域：（a）研究单手性碳纳米管的自下而上的有机合成;（B）使用茚并芴和扩大的醌式类似物作为有机电子学的电子接受支架;（c）使用分子探针进行小分子/离子识别;（d）使用分子探针进行有机电子学的研究。（d）合成铁-膦大环络合物，用作天然气净化中的液相吸附剂;（f）了解生物二氢化硫和（g）在核糖核酸生物化学中使用铂（II）试剂。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Michael Pluth from the University of Oregon Eugene and colleague Ramesh Jasti have acquired a high resolution liquid chromatograph mass spectrometer (LCMS) with electrospray ionization (ESI) and ultra performance liquid chromatograhic (UPLC) capabilities. This instrument is placed at the open access CAMCOR (Center for Advanced Materials and Characterization in Oregon) facility at the University of Oregon. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex mixtures. This highly sensitive technique allows detection and determination of the structure of molecules in a complex mixture. An instrument with a liquid chromatograph provides additional structural identification power by separating mixtures of compounds before they reach the mass spectrometer. In an ESI source, a high voltage is applied to a liquid to produce an aerosol that facilitates the production of ions. The acquisition strengthens the research infrastructure at the University and regional area. The instrument also broaden participation by involving diverse students in research and research training using this modern analytical technique. It also provides training opportunities to a large number of undergraduate, graduate and postdoctoral students as well as high school students through a variety of internship programs. The new capabilities in CAMCOR offer great opportunities to both academic and industrial users. The proposal is aimed at enhancing research and education at all levels, especially in areas such as (a) studying the bottom-up organic synthesis of single-chirality carbon nanotubes; (b) using indenofluorene and expanded quinoidal analogues as electron-accepting scaffolds for organic electronics; (c) using molecular probes for small molecule/ion recognition; (d) synthesizing iron-phosphine macrocycle complexes for use as liquid phase adsorbents in the purification of natural gas; (e) synthesizing precision engineered nanoparticles; (f) understanding biological sulfur dihydride and (g) using platinum(II) reagents in ribonucleic acid (RNA) biochemistry.