权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

MRI: Acquisition of a High Resolution Mass Spectrometer for Research and Education at a University of Oregon Facility

MRI：俄勒冈大学设施购买高分辨率质谱仪用于研究和教育

基本信息

批准号：
1625529
负责人：
Michael Pluth
金额：
$ 17.41万
依托单位：
University of Oregon Eugene
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-15 至 2021-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1625529&HistoricalAwards=false
关键词：
MRI Acquisition Resolution Mass Spectrometer

项目摘要

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Michael Pluth from the University of Oregon Eugene and colleague Ramesh Jasti have acquired a high resolution liquid chromatograph mass spectrometer (LCMS) with electrospray ionization (ESI) and ultra performance liquid chromatograhic (UPLC) capabilities. This instrument is placed at the open access CAMCOR (Center for Advanced Materials and Characterization in Oregon) facility at the University of Oregon. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex mixtures. This highly sensitive technique allows detection and determination of the structure of molecules in a complex mixture. An instrument with a liquid chromatograph provides additional structural identification power by separating mixtures of compounds before they reach the mass spectrometer. In an ESI source, a high voltage is applied to a liquid to produce an aerosol that facilitates the production of ions. The acquisition strengthens the research infrastructure at the University and regional area. The instrument also broaden participation by involving diverse students in research and research training using this modern analytical technique. It also provides training opportunities to a large number of undergraduate, graduate and postdoctoral students as well as high school students through a variety of internship programs. The new capabilities in CAMCOR offer great opportunities to both academic and industrial users. The proposal is aimed at enhancing research and education at all levels, especially in areas such as (a) studying the bottom-up organic synthesis of single-chirality carbon nanotubes; (b) using indenofluorene and expanded quinoidal analogues as electron-accepting scaffolds for organic electronics; (c) using molecular probes for small molecule/ion recognition; (d) synthesizing iron-phosphine macrocycle complexes for use as liquid phase adsorbents in the purification of natural gas; (e) synthesizing precision engineered nanoparticles; (f) understanding biological sulfur dihydride and (g) using platinum(II) reagents in ribonucleic acid (RNA) biochemistry.

在主要研究仪器项目（MRI）和化学研究仪器项目（CRIF）的支持下，俄勒冈大学尤金分校的Michael Pluth教授和他的同事Ramesh Jasti获得了一台具有电喷雾电离（ESI）和超性能液相色谱（UPLC）功能的高分辨率液相色谱质谱仪（LCMS）。该仪器被放置在俄勒冈大学的CAMCOR（俄勒冈州先进材料和表征中心）设施中。一般来说，质谱（MS）是用于鉴定和表征复杂混合物中嵌入的少量化学物质的关键分析方法之一。这种高度灵敏的技术可以检测和确定复杂混合物中的分子结构。带有液相色谱仪的仪器通过在混合物到达质谱仪之前将其分离来提供额外的结构识别能力。在ESI源中，对液体施加高电压以产生有利于离子产生的气溶胶。此次收购加强了大学和地区的研究基础设施。该仪器还通过让不同的学生参与使用这种现代分析技术的研究和研究培训来扩大参与。通过各种实习项目，为大批本科生、研究生、博士后和高中生提供培训机会。CAMCOR的新功能为学术和工业用户提供了巨大的机会。该提案旨在加强各级的研究和教育，特别是在以下领域：(a)研究自下而上的单手性碳纳米管有机合成；(b)使用茚芴和膨胀的喹啉类似物作为有机电子产品的电子接受支架；(c)使用分子探针进行小分子/离子识别；(d)合成铁膦大环配合物，用作天然气净化中的液相吸附剂；(e)合成精密工程纳米粒子；(f)了解生物二氢化硫和(g)在核糖核酸（RNA）生物化学中使用铂（II）试剂。