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CREST Center for Cellular and Biomolecular Machines

CREST 细胞和生物分子机器中心

基本信息

批准号：
2112675
负责人：
Victor Munoz
金额：
$ 500万
依托单位：
University of California - Merced
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2027-08-31
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2112675&HistoricalAwards=false
关键词：
CREST Center Cellular Biomolecular Machines

项目摘要

Center for Biological Signatures and SensingThe Centers of Research Excellence in Science and Technology (CREST) program supports the enhancement of research capabilities of minority-serving institutions through the establishment of centers that effectively integrate education and research. CREST promotes the development of new knowledge, enhancements of the research productivity of individual faculty, and an expanded presence of students historically underrepresented in science, technology, engineering, and mathematics disciplines. With National Science Foundation support, the University of California – Merced builds on the successes of the Center for Cellular and Biomolecular Machines (CCBM) Phase I, leading to institutional transformation and new scientific horizons. In Phase II, the Center will use an interdisciplinary approach cutting across scientific and engineering methodologies to:•pursue a fundamental understanding of the adaptive and responsive functioning of multi-scale biomolecular and cellular assemblies that enable control of function in vivo; •use these fundamental principles for designing and developing novel bio-inspired functioning machines ranging from designer nanodevices, cells and tissue to diagnostic and therapeutic devices; and•refine, augment, and institutionalize CCBM’s signature integrated, interdisciplinary graduate training program that combines scientific and professional skills with supervision of research and training experiences for undergraduate and high school students aimed at enhancing and developing career opportunities for underrepresented minorities in STEM fields.By integrating research and education, the Center aims to develop a robust pipeline for underrepresented minorities in the STEM workforce at all levels and produce graduates in both physical and biological sciences and can pursue cross-disciplinary STEM careers in academia, laboratories or industry.Three thrusts are presented and defined according to their scale (nano, meso, and multicellular). Thrust 1: Protein Metamorphosis and Responsive Nanodevices. Phase II research focuses on the emerging theme of protein metamorphosis as mechanism to enable natural and synthetic controllable biological nanodevices, organized in two broad areas: the functional roles of gradually morphing proteins; and engineering of control systems of the assembly-disassembly of biological macromolecular assemblies. Thrust 2: Adaptive and Responsive Mesoscale Assemblies. In Phase II, the focus is to understand the mechanisms that enable assemblies to function collectively in adaptive and responsive ways as well as exploiting them for applications. Thrust 3: Adaptive Cellular Communication. Phase II will examine the impact of cell-cell and cell-matrix mechanical interactions on collective cell motility, patterning and the emergence of function, combining experimental and modeling approaches.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物签名和传感中心卓越科学技术研究中心（CREST）计划通过建立有效整合教育和研究的中心，支持提高少数民族服务机构的研究能力。CREST促进了新知识的发展，提高了个别教师的研究生产力，扩大了在科学、技术、工程和数学学科中历史上代表性不足的学生的存在。在美国国家科学基金会的支持下，加州大学默塞德分校在细胞和生物分子机器中心（CCBM）第一阶段的成功基础上，实现了机构转型和新的科学视野。在第二阶段，该中心将采用跨学科的方法，跨越科学和工程方法，以：•追求对多尺度生物分子和细胞组装的适应性和响应功能的基本理解，从而实现体内功能的控制；•使用这些基本原则来设计和开发新颖的生物启发功能机器，从设计纳米设备，细胞和组织到诊断和治疗设备；完善、扩大和制度化CCBM标志性的综合跨学科研究生培训计划，该计划将科学和专业技能与本科生和高中生的研究和培训经验的监督相结合，旨在为STEM领域中代表性不足的少数民族增加和发展就业机会。通过整合研究和教育，该中心旨在为各级STEM劳动力中代表性不足的少数民族开发强大的管道，培养物理和生物科学的毕业生，并可以在学术界，实验室或工业领域从事跨学科的STEM职业。根据它们的尺度（纳米、中观和多细胞），提出并定义了三种推力。主旨1：蛋白质变态和响应纳米器件。第二阶段的研究重点是蛋白质变形这一新兴主题，作为实现自然和合成可控生物纳米器件的机制，组织在两大领域：逐渐变形的蛋白质的功能作用；生物大分子组装-拆卸控制系统工程。推力2：自适应和响应的中尺度集合。在阶段II中，重点是理解使程序集能够以自适应和响应的方式共同工作的机制，以及将它们用于应用程序。推力3：自适应蜂窝通信。第二阶段将结合实验和建模方法，研究细胞-细胞和细胞-基质机械相互作用对集体细胞运动、模式和功能出现的影响。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（31）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Compliant mechanical response of the ultrafast folding protein EnHD under force

DOI：
10.1038/s42005-022-01125-5
发表时间：
2023-01-12
期刊：
COMMUNICATIONS PHYSICS
影响因子：
5.5
作者：
Reifs，Antonio;Ortiz，Irene Ruiz;Perez-Jimenez，Raul
通讯作者：
Perez-Jimenez，Raul

Inflammasome regulation by adaptor isoforms, ASC and ASCb, via differential self-assembly.

DOI：
10.1016/j.jbc.2022.101566
发表时间：
2022-03
期刊：
The Journal of biological chemistry
影响因子：
0
作者：
Diaz-Parga P;de Alba E
通讯作者：
de Alba E

Reconstitution of an intact clock reveals mechanisms of circadian timekeeping.

DOI：
10.1126/science.abd4453
发表时间：
2021-10-08
期刊：
Science (New York, N.Y.)
影响因子：
0
作者：
Chavan AG;Swan JA;Heisler J;Sancar C;Ernst DC;Fang M;Palacios JG;Spangler RK;Bagshaw CR;Tripathi S;Crosby P;Golden SS;Partch CL;LiWang A
通讯作者：
LiWang A

Glycosaminoglycans and glycoproteins influence the elastic response of synovial fluid nanofilms on model oxide surfaces