Center for Cellular Metabolism Research in Oklahoma

俄克拉荷马州细胞代谢研究中心

• 批准号: 10090975
• 负责人: Lijun Xia
• 金额: $ 262.2万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-05 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090975
• 关键词: Address; Aging; Area; Arthritis; Autoimmune Diseases; Biological Models; Biology of Aging; Biomedical Research; Cardiovascular Diseases; Cardiovascular system; Cells; Centers of Research Excellence; Clinical Immunology; Core Facility; Development; Diabetes Mellitus; Disease; Environment; Equipment; Faculty; Fostering; Foundations; Funding; Goals; Growth; Health; Human Resources; Infrastructure; Interdisciplinary Study; Leadership; Life; Malignant Neoplasms; Medical Research; Mentors; Metabolism; Oklahoma; Pathogenesis; Phase; Records; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Scientist; Secure; Training; Universities; Work; career; collaborative environment; environmental change; experience; interest; member; multidisciplinary; novel; professor; programs; recruit; repaired; success; tenure track

Altered cellular metabolism contributes to the pathogenesis of many common diseases, such as cardiovascular disease, cancer, diabetes, and autoimmune disorders, which are prevalent in Oklahoma. However, metabolism- related research resources and infrastructure are currently insufficient and scattered in Oklahoma. To address these deficiencies, this Center for Cellular Metabolism Research in Oklahoma (CMRO) Phase I COBRE will create and nurture excellence in cellular metabolism in Oklahoma. The CMRO is located at the Oklahoma Medical Research Foundation (OMRF), a leading biomedical research institute. The central focus of the CMRO is to support five new Assistant Member-level faculty (equivalent to tenure-track Assistant Professor at a Research University) as Project Leaders from three different OMRF Research Programs: Cardiovascular Biology (CVB), Aging & Metabolism (AM), and Arthritis & Clinical Immunology (ACI). These new junior investigators are the foundation for expansion and unification of cellular metabolism research. They will receive an appropriate level and form of multidisciplinary mentoring from experienced and competitive scientists. The CMRO COBRE aims to develop a critical mass of investigators who can secure external funding to support their research while creating a new, exciting, multidisciplinary, and collaborative environment for sustained competitive research on cellular metabolism in Oklahoma, which will be achieved through five Aims: 1) Support five promising young Project Leaders to scientific independence through incorporation of cellular metabolism research in their labs; 2) Promote novel multidisciplinary research focusing on cellular metabolism through mentoring the junior Project Leaders from three different OMRF Research Programs; 3) Integrate existing and new resources through Core facilities that support cellular metabolism research; 4) Promote an environment that supports the success and development of an independent sustainable center. The COBRE support will be critical to create a new, multidisciplinary and collaborative environment for sustained competitive research on cellular metabolism in Oklahoma.

改变的细胞代谢有助于许多常见疾病的发病机制，如心血管疾病， 疾病、癌症、糖尿病和自身免疫性疾病，这些疾病在俄克拉荷马州普遍存在。然而，新陈代谢- 相关的研究资源和基础设施目前不足，分散在俄克拉荷马州。解决 这些不足之处，这个俄克拉荷马州细胞代谢研究中心（CMRO）第一阶段COBRE将 在俄克拉荷马州创造和培养卓越的细胞代谢。CMRO位于俄克拉荷马州 医学研究基金会（OMRF），一个领先的生物医学研究机构。CMRO的核心焦点 是支持五个新的助理教授级教师（相当于终身助理教授在一个 作为项目负责人，来自三个不同的OMRF研究项目：心血管生物学 (CVB)老化与代谢（AM）和关节炎与临床免疫学（ACI）。这些新的初级调查员是 为细胞代谢研究的扩展和统一奠定了基础。他们将得到适当的 由经验丰富和有竞争力的科学家提供多学科指导的水平和形式。CMRO COBRE 旨在培养一批能够获得外部资金支持其研究的关键调查人员， 创造一个新的，令人兴奋的，多学科和协作的环境，持续的竞争性研究， 细胞代谢在俄克拉荷马州，这将通过五个目标实现：1）支持五个有前途的年轻 通过在实验室中纳入细胞代谢研究，项目领导人可以实现科学独立性; 2） 通过指导初级项目，促进以细胞代谢为重点的新的多学科研究 来自三个不同OMRF研究项目的领导者; 3）通过核心整合现有和新的资源 支持细胞代谢研究的设施; 4）促进支持成功的环境， 建立独立的可持续发展中心。COBRE的支持对于创建一个新的， 多学科和协作环境的持续竞争性研究细胞代谢， 俄克拉荷马州。