MRI: Acquisition of a Single-Crystal X-Ray Diffractometer for Research and Education

MRI：购买用于研究和教育的单晶 X 射线衍射仪

• 批准号: 2117516
• 负责人: Elisa Tomat
• 金额: $ 26.62万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117516&HistoricalAwards=false
• 关键词: MRI; Acquisition; Single; Crystal; Ray

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of Arizona is acquiring a single crystal X-ray diffractometer (SCXRD) to support Professor Elisa Tomat and colleagues Wei Wang, Jon Njardarson, Thomas Gianetti and Tai Kong. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry, and biochemistry. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students, including veterans, in chemistry and biochemistry at this Hispanic Serving Institution as well as collaborators from other regional universities in the Southwest (Arizona/New Mexico region). The award of this diffractometer is aimed at enhancing research and education at all levels. It especially impacts the exploration of coordination chemistry strategies in bioinorganic redox reactivity and cell biology and the design of organic reactions such as those for total natural product synthesis. The instrumentation is also used for developing carbenium-based ligands for catalytic applications and the development of chemical tools for biology and potential drug discovery. The instrument also serves researchers searching for natural-product-based compounds that may act as therapeutics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目支持。亚利桑那大学正在获得单晶x射线衍射仪（SCXRD），以支持Elisa Tomat教授及其同事Wei Wang， Jon Njardarson， Thomas Gianetti和Tai Kong。一般来说，x射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于邻近分子的空间排列的准确信息。这里描述的研究影响许多领域，包括有机和无机化学，材料化学和生物化学。该仪器是该西班牙裔服务机构的化学和生物化学本科生和研究生（包括退伍军人）以及西南（亚利桑那州/新墨西哥州地区）其他地区大学的合作者的教学、研究和研究培训的组成部分。该衍射仪的奖项旨在加强各级的研究和教育。它尤其影响了生物无机氧化还原反应和细胞生物学中配位化学策略的探索，以及有机反应的设计，如天然产物的合成。该仪器还用于开发用于催化应用的碳基配体，以及开发用于生物学和潜在药物发现的化学工具。该仪器还为研究人员寻找可能作为治疗药物的天然产物化合物提供服务。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Primary amines as ligands and linkers in complexes of tripyrrindione radicals

伯胺作为三吡啶二酮自由基复合物中的配体和连接体

• DOI: 10.1142/s1088424623501109
• 发表时间: 2023
• 期刊: Journal of Porphyrins and Phthalocyanines
• 影响因子: 1.5
• 作者: Habenšus, Iva;Ghavam, Ameen;Curtis, Clayton J.;Astashkin, Andrei V.;Tomat, Elisa
• 通讯作者: Tomat, Elisa

Anionic Amino-Cope Rearrangement Cascade Synthesis of 2,4-Substituted Benzoate Esters from Acyclic Building Blocks

由无环结构单元阴离子氨基-Cope重排级联合成 2,4-取代苯甲酸酯

• DOI: 10.1021/acs.orglett.2c03134
• 发表时间: 2022
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Qureshi, M. Haziq;Njardarson, Jon T.
• 通讯作者: Njardarson, Jon T.