MRI: Acquisition of a Single Crystal X­-ray Diffractometer (SC-XRD) to Strengthen Research in RI and Greater New­ England

MRI：购买单晶 X 射线衍射仪 (SC-XRD) 以加强 RI 和大新英格兰地区的研究

• 批准号: 2117549
• 负责人: Jerome Robinson
• 金额: $ 29万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117549&HistoricalAwards=false
• 关键词: MRI; Acquisition; Single; Crystal; ray

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Brown University is acquiring a single crystal X-ray diffractometer (SCXRD) to support Professor Jerome Robinson and colleagues Lai-Sheng Wang, Ming Xian, Eunsuk Kim and Paul Williard. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry, and biochemistry. This instrument is an integral part of teaching, research and research training of undergraduate and graduate students in chemistry and biochemistry as well as collaborators from eleven regional universities in the New England area. The award of this diffractometer is aimed at enhancing research and education at all levels, especially in areas. It especially impacts the elucidation of the structures of reactive multinuclear reduced oxygen species of copper and catalysts for the synthesis of biodegradable polymers and the characterization of reactive intermediates relevant to iron-sulfur clusters and their reactivity with hydrogen sulfide, nitrous oxide, and oxygen species. The instrumentation is also used for determining the structure of gold and gold hydride clusters and the absolute structure of species derived from biorthogonal reactive sulfur species. The instrument also serves researchers establishing the structure of organolithium aggregates which are key to understand selectivity for abundant carbon–carbon bond forming reactions. Some projects using the diffractometer fro neighboring institutions involve elucidation of the structures of metal-based small-peptide with possible therapeutic properties (U Rhode Island) and determining the structure of small molecule inhibitors of the enzyme O-GlcNacase (Bryant U) and identifying potential catalytic intermediates of iron-based carbon dioxide reduction catalysts (Providence College). Two additional projects from U Conn that also utilize the diffractometer are the determination of the structure of catalyst intermediates involved in electrocatalytic and photocatalytic reduction of carbon dioxide and the establishment of the solid-state structure-function relationships for complexes of copper and the lanthanides which display some of the brightest circularly-polarized luminescence.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。布朗大学正在购买一台单晶X射线衍射仪（SCXRD），以支持杰罗姆罗宾逊教授及其同事王莱生、贤明、金恩淑和保罗·威廉德。一般来说，X射线衍射仪允许准确和精确地测量分子的完整三维结构，包括键距和角度，并提供关于分子相对于相邻分子的空间排列的准确信息。这里描述的研究影响了许多领域，包括有机和无机化学，材料化学和生物化学。该仪器是化学和生物化学本科生和研究生以及来自新英格兰地区11所地区大学的合作者的教学，研究和研究培训的组成部分。该衍射仪的获奖旨在加强各级研究和教育，特别是在以下领域。它特别影响的反应性多核还原的氧物种的铜和催化剂的结构的阐明，用于合成可生物降解的聚合物和表征的反应性中间体相关的铁-硫簇及其与硫化氢，一氧化二氮，和氧物种的反应。该仪器也用于确定金和金氢化物簇的结构和来自双正交活性硫物种的物种的绝对结构。该仪器还为研究人员提供了建立有机锂聚集体结构的服务，这是理解丰富的碳-碳键形成反应选择性的关键。来自邻近机构的使用衍射仪的一些项目涉及具有可能的治疗特性的金属基小肽的结构的阐明（U罗得岛）和确定酶O-GlcNacase的小分子抑制剂的结构（Bryant U）和鉴定铁基二氧化碳还原催化剂的潜在催化中间体（普罗维登斯学院）。康涅狄格大学的另外两个项目也使用了衍射仪，它们是测定二氧化碳电催化和光催化还原中涉及的催化剂中间体的结构，以及建立铜和镧系元素络合物的固态结构-功能关系，这些络合物显示出一些最亮的圆形-该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。