I-Corps: Biomimetic Engineered Space Technology Platform

I-Corps:仿生工程空间技术平台

基本信息

  • 批准号:
    2132369
  • 负责人:
  • 金额:
    $ 5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-06-01 至 2022-08-31
  • 项目状态:
    已结题

项目摘要

The broader impact/commercial potential of this I-Corps project is to provide cost reduction and time-saving for researchers in academia and industry in designing studies to be conducted in an extraterrestrial gravity environment (e.g., low-Earth orbit, Martian gravity, or lunar gravity). Currently, pharmaceutical companies and researchers in academia (biology, chemistry, bioengineering fields) need a platform for producing reliable and replicable data in simulated extraterrestrial gravity before sending the experiments to the International Space Station (ISS). While the experimental set-up size limitation at ISS requires diligent optimization of independent variables in experiments, the high flight cost to the ISS and one-time opportunity in running experiments there necessitates absolute success in experimental execution with already tested experimental parameters. This technology provides time and cost effective solutions to overcome the shortcomings of experimental preparations prior to launching to the ISS. This core technology also has potential applications for improving outcomes for elderly populations and patients with prolonged immobility. The creation of knowledge in this area can benefit drug development and rehabilitation efforts aimed at revitalizing deteriorating tissues caused by prolonged immobilization.This I-Corps project simulates extraterrestrial gravity to study the gravity-sensitive mechanisms of organic and inorganic materials, cells, tissues, and organs in a three-dimensional dynamic environment. The key technical innovations underpinning the platform involve being able to mimic a varying gravitational environment on Earth and monitor the gravitational forces in situ. It necessary, the technology will also be able to modulate conditions while providing realistic culturing and processing environments for cells, proteins, and materials. The platform uses an innovative technique to reach a pre-defined gravitational state in 60-90 seconds by independently rotating two computer-controlled axes. The data acquisition chip placed in the device collects and plots the gravity data for a user to track/observe the gravitational force. Another technical innovation of this I-Corps project is that various mechanical strains can be applied to the sample of interest in a temperature, light, and humidity-controlled environment to study the samples in realistic conditions under a pre-defined, simulated gravitational state.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个I-Corps项目的更广泛的影响/商业潜力是为学术界和工业界的研究人员在设计在地外重力环境中进行的研究时降低成本和节省时间(例如,低地球轨道、火星重力或月球重力)。 目前,制药公司和学术界(生物学、化学、生物工程领域)的研究人员需要一个平台,在将实验发送到国际空间站(ISS)之前,在模拟地外重力下生成可靠和可复制的数据。虽然国际空间站的实验装置规模有限,需要在实验中努力优化自变量,但国际空间站的飞行成本很高,而且在那里进行实验的机会是一次性的,因此必须用已经测试过的实验参数在实验执行中取得绝对成功。这项技术提供了时间和成本效益的解决方案,以克服发射到国际空间站之前实验准备的缺点。这项核心技术还具有改善老年人群和长期不动患者预后的潜在应用。该领域的知识创造有助于药物开发和康复工作,旨在使因长期固定而恶化的组织恢复活力。I-Corps项目模拟地球外重力,研究有机和无机材料、细胞、组织和器官在三维动态环境中的重力敏感机制。该平台的关键技术创新包括能够模拟地球上变化的重力环境并原位监测重力。 必要时,该技术还将能够调节条件,同时为细胞,蛋白质和材料提供真实的培养和加工环境。该平台采用创新技术,通过独立旋转两个计算机控制的轴,在60-90秒内达到预定义的重力状态。 放置在设备中的数据采集芯片收集并绘制重力数据,以供用户跟踪/观察重力。 这个I-Corps项目的另一个技术创新是,可以在温度、光照和湿度受控的环境中对感兴趣的样品施加各种机械应变,以在预定义的、该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查进行评估,被认为值得支持的搜索.

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Eda Yildirim-Ayan其他文献

Tideglusib enhances ALP activity and upregulates RANKL expression in Osteoblast-macrophage Co-cultures within a 3D collagen scaffold
  • DOI:
    10.1016/j.jdent.2024.105509
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Raquel Toledano;María T. Osorio;Raquel Osorio;Manuel Toledano;Diego Jacho;Eda Yildirim-Ayan
  • 通讯作者:
    Eda Yildirim-Ayan
Correction to: Mechano-Immunomodulation: Mechanoresponsive Changes in Macrophage Activity and Polarization
  • DOI:
    10.1007/s10439-019-02326-w
  • 发表时间:
    2019-08-06
  • 期刊:
  • 影响因子:
    5.400
  • 作者:
    Sarah Adams;Leah M. Wuescher;Randall Worth;Eda Yildirim-Ayan
  • 通讯作者:
    Eda Yildirim-Ayan
Mechano-Immunomodulation: Mechanoresponsive Changes in Macrophage Activity and Polarization
  • DOI:
    10.1007/s10439-019-02302-4
  • 发表时间:
    2019-06-19
  • 期刊:
  • 影响因子:
    5.400
  • 作者:
    Sarah Adams;Leah M. Wuescher;Randall Worth;Eda Yildirim-Ayan
  • 通讯作者:
    Eda Yildirim-Ayan

Eda Yildirim-Ayan的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Eda Yildirim-Ayan', 18)}}的其他基金

PFI-TT: Biomimetic Engineered Space Technology Platform
PFI-TT:仿生工程空间技术平台
  • 批准号:
    2213958
  • 财政年份:
    2022
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
I-Corps: Dynamic Tissue Culture Platform for in vitro Drug Screening
I-Corps:用于体外药物筛选的动态组织培养平台
  • 批准号:
    1646731
  • 财政年份:
    2016
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant

相似海外基金

Engineered biomimetic materials for intestinal mucosal healing
用于肠粘膜愈合的工程仿生材料
  • 批准号:
    10719681
  • 财政年份:
    2023
  • 资助金额:
    $ 5万
  • 项目类别:
PFI-TT: Biomimetic Engineered Space Technology Platform
PFI-TT:仿生工程空间技术平台
  • 批准号:
    2213958
  • 财政年份:
    2022
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
3D biomimetic lymph node engineered extracellular vesicles for understanding the heterogeneity of adaptive immunity
3D 仿生淋巴结工程细胞外囊泡用于了解适应性免疫的异质性
  • 批准号:
    10018925
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
3D biomimetic lymph node engineered extracellular vesicles for understanding the heterogeneity of adaptive immunity
3D 仿生淋巴结工程细胞外囊泡用于了解适应性免疫的异质性
  • 批准号:
    10671080
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
REU Site: Biomimetic and Soft Robotics (BioSoRo): from Biological Inspirations to Engineered Mechanisms
REU 网站:仿生和软机器人 (BioSoRo):从生物学灵感到工程机制
  • 批准号:
    1852578
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant
3D biomimetic lymph node engineered extracellular vesicles for understanding the heterogeneity of adaptive immunity
3D 仿生淋巴结工程细胞外囊泡用于了解适应性免疫的异质性
  • 批准号:
    10457383
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
3D biomimetic lymph node engineered extracellular vesicles for understanding the heterogeneity of adaptive immunity
3D 仿生淋巴结工程细胞外囊泡用于了解适应性免疫的异质性
  • 批准号:
    10677366
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
3D biomimetic lymph node engineered extracellular vesicles for understanding the heterogeneity of adaptive immunity
3D 仿生淋巴结工程细胞外囊泡用于了解适应性免疫的异质性
  • 批准号:
    10268195
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
3D biomimetic lymph node engineered extracellular vesicles for understanding
3D 仿生淋巴结工程细胞外囊泡用于理解
  • 批准号:
    10378176
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
3D biomimetic lymph node engineered extracellular vesicles for understanding the heterogeneity of adaptive immunity
3D 仿生淋巴结工程细胞外囊泡用于了解适应性免疫的异质性
  • 批准号:
    10727055
  • 财政年份:
    2019
  • 资助金额:
    $ 5万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了