PFI-TT: Biomimetic Engineered Space Technology Platform

PFI-TT：仿生工程空间技术平台

• 批准号: 2213958
• 负责人: Eda Yildirim-Ayan
• 金额: $ 25万
• 依托单位: University of Toledo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2213958&HistoricalAwards=false
• 关键词: PFI; TT; Biomimetic; Engineered; Space

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) is to increase the consistency, reliability, and repeatability of in vitro and ex vivo cell and organ testing methods before sending experiments to the International Space Station. The technology seeks to simulate various partial gravity conditions, including low Earth orbit and Martian and lunar gravities. The project provides a platform to study cells and organs in different gravitational conditions without significant expense. The proposed technology seeks to provide an environment to study how prolonged immobilization (pseudo-weightlessness) affects cells and musculoskeletal organs and may have impacts on individuals sent to space. The creation of knowledge in this area may benefit the drug development and rehabilitation efforts focused on revitalizing deteriorated tissues after prolonged immobilization.The proposed project seeks to prototype a technology that can simulate partial gravity conditions while culturing three-dimensional (3D) tissues, tissue analogs, and ex vivo organs for the study of human diseases and physiology under relevant mechanical and chemical conditions. Currently, commercially-available partial gravity simulators culture two-dimensional (2D) cell monolayers. This limits scientists' ability to study human diseases and physiology under simulated partial gravity environments. The team will conduct operational parameter-based and cellular-based functional tests on various culturing systems with different complexities under a number of partial gravity conditions. The proposed technology may advance regenerative medicine, regenerative rehabilitation, and mechanobiology fields by offering a versatile platform to study cell-cell and cell-matrix interactions within a three dimensional(3D) matrix.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这种创新-技术转化伙伴关系（PFI-TT）的更广泛影响/商业潜力是在将实验发送到国际空间站之前提高体外和离体细胞和器官测试方法的一致性，可靠性和可重复性。该技术旨在模拟各种部分重力条件，包括低地球轨道和火星和月球重力。该项目提供了一个在不同重力条件下研究细胞和器官的平台，而无需大量费用。拟议的技术旨在提供一个环境，以研究长期固定（伪失重）如何影响细胞和肌肉骨骼器官，并可能对被送往太空的个人产生影响。这一领域的知识创造可能有助于药物开发和康复工作，重点是恢复长期固定后退化的组织。拟议的项目旨在建立一种技术原型，该技术可以模拟部分重力条件，同时培养三维（3D）组织，组织类似物和离体器官，用于在相关机械和化学条件下研究人类疾病和生理学。目前，可商购的部分重力模拟器培养二维（2D）细胞单层。这限制了科学家在模拟部分重力环境下研究人类疾病和生理的能力。该团队将在一些部分重力条件下对各种复杂性不同的培养系统进行基于操作参数和基于细胞的功能测试。这项技术可以通过提供一个多功能的平台来研究三维（3D）矩阵中的细胞-细胞和细胞-基质相互作用，从而推进再生医学，再生康复和机械生物学领域。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。