FMSG: Bio-Manufacturing of Hybrid Tissue-Electronic and Photonic Devices

将活组织与电子和光子器件集成的能力具有影响人类健康的许多方面的潜力，包括神经/神经肌肉疾病和损伤，例如脊髓损伤和阿尔茨海默病以及分泌病理学，例如糖尿病和青光眼。到目前为止，生物电子设备已被用于几个领域，最值得注意的是心脏起搏器，人工耳蜗植入物，这使得成千上万的深度失聪的人能够在听觉世界中进行交流，以及深部脑刺激，这在20世纪90年代被广泛用于治疗帕金森病和原发性震颤。尽管这些装置取得了成功，但生物电和生物光子装置的潜力几乎没有实现，部分地受到装置与活组织的接口挑战以及由于装置插入而导致的潜在组织损伤的限制。这项未来的制造种子资助将开发新的制造方法，以创造生物相容的电子和光子器件（即，能够促进健康生物组织的生长和功能）并且是生物弹性的（即，能够承受生物系统的湿的、咸的、蛋白质化学环境）。此外，它还将解决如何将活组织与电子和光子设备连接起来，以便信息（例如，脑电信号、肌肉刺激、神经元反应）可以在电子或光子装置与生命系统之间传递。该项目将建立在现有的半导体技术和生物医学先进技术的先进技术教育计划，以确定制造领域所需的核心能力，并在社区学院，学士，硕士和博士学位水平培训劳动力，通过我们与社区学院合作伙伴的互动和与行业的接触，扩大参与，以确保开发的课程仍然响应行业需要。最后，将根据项目小组与工业咨询委员会确定的核心能力制定详细的课程，并在主要社区学院以及纽约州立大学理工学院和奥尔巴尼药学与健康科学学院的学士和硕士课程中进行试点。学员和工业顾问委员会的意见将用于改进课程，以便在未来制造业研究资助阶段更广泛地应用。这个未来制造项目由工程局的ECCS和CBET部门共同资助。利用纽约州立大学理工学院的优势，AIM Photonics（一个由联邦政府资助的美国制造业研究所实体，位于纽约州立大学理工学院），东北先进技术教育中心（NSF资助的培训项目）和合作伙伴，包括奥尔巴尼药学与健康科学学院和神经干细胞研究所，这项未来的制造种子基金将专注于硅晶片电子和光子器件的设计和制造，有两个技术目标：1）设计和制造硅晶片电子和光子器件，以与生物材料接口，2）开发用于电和光子相互作用的接口，并测量3D培养物。为了确定在制造规模上解决这些挑战的障碍，该项目将包括集中在两个测试平台上的初步研究：1）实施可以测量眼组织流出的压力传感设备，以解决青光眼治疗的发展; 2）创建与三维细胞培养物（例如，神经元类器官）用于电刺激和观察。这些试验台实验的一个重要重点将是可制造性设计，以实现从实验室设备到制造设备的过渡。此外，本发明还提供了一种方法，将与广泛的学术界和工业界合作伙伴举行一系列研讨会，以确定在随后的未来制造研究资助中要解决的其他研究和制造问题。该未来制造项目由工程局的ECCS和CBET部门共同资助。该奖项反映了NSF的法定使命，并通过使用基金会的学术价值和更广泛的影响评审标准。

The ability to integrate living tissues with electronic and photonic devices has potential to impact many aspects of human health, including neurological/neuromuscular disease and injury, such as spinal cord injury and Alzheimer's disease and secretory pathologies, such as diabetes and glaucoma. To date, bioelectronic devices have been employed in several arenas, most notably cardiac pacemakers, cochlear implants, which have enabled tens of thousands of profoundly deaf people to communicate in a hearing world, and deep brain stimulation, which became widely used in the 1990’s to treat Parkinson disease and essential tremor. Despite the success of these devices, the potential for bioelectrical and biophotonic devices has scarcely been realized, limited in part by challenges in interfacing devices with living tissues and the potential tissue damage due to device insertion. This future manufacturing seed grant will develop new manufacturing methods to create electronic and photonic devices that are biocompatible (i.e., able to facilitate growth and function of healthy biological tissues) and are bio-resilient (i.e., able to withstand the wet, salty, proteinaceous chemical environment of biological systems). In addition, it will address how to interface the living tissue with electronic and photonic devices so that information (e.g., brain electrical signals, muscle stimulation, neuronal responses) can be transferred between the electronic or photonic device and the living system. This project will build on existing advanced technical education programs in semiconductor technologies and biomedical advanced technologies to identify the core competencies required for the field of manufacturing and train a workforce at the community college, bachelors, masters, and doctoral degree level, broadening participation through our interactions with community college partners and engaging with industry to ensure that the curriculum developed remains responsive to industry needs. Finally, a detailed curriculum based upon core competencies identified by the project team in conjunction with the Industrial Advisory Board will be developed and piloted at key community colleges and in bachelors and masters level programs at SUNY Polytechnic Institute and Albany College of Pharmacy and Health Sciences. Feedback from trainees and the Industrial Advisory Board will be used to refine the curriculum for wider deployment in the Future Manufacturing Research Grant phase. This Future Manufacturing project is jointly funded by the Divisions of ECCS and CBET in the Directorate of Engineering. Leveraging the strengths of SUNY Polytechnic Institute, AIM Photonics (a federally-funded American Institute for Manufacturing entity located at SUNY Polytechnic Institute), the Northeast Advanced Technological Education Center (an NSF-funded training program) and partners including Albany College of Pharmacy and Health Sciences and the Neural Stem Cell Institute, this future manufacturing seed grant will focus on design and manufacturing of silicon-wafer electronic and photonic devices with two technical objectives: 1) Design and manufacture of silicon-wafer electronic and photonic devices to interface with biological materials and 2) Development of interfaces for electrical and photonic interaction and measurement of 3D cultures. To identify the barriers to addressing these challenges at the manufacturing scale, the project will include preliminary research focused on two testbeds: 1) Implementation of a pressure sensing device that can measure outflow from ocular tissues to address development of glaucoma therapeutics; 2) Creation of multielectrode arrays interfaced with three-dimensional cell cultures (e.g., neuronal organoids) for electrical stimulation and observation. A significant focus in these testbed experiments will be on design for manufacturability, to enable the transition from laboratory devices to manufactured devices. In addition, a series of workshops with a wide range of academic and industrial partners will be conducted to identify additional research and manufacturing issues to be addressed in a subsequent Future Manufacturing Research Grant.This Future Manufacturing project is jointly funded by the Divisions of ECCS and CBET in the Directorate of Engineering.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.