Catalytic Synthesis for Saturated Heterocycles

饱和杂环化合物的催化合成

• 批准号: 2154820
• 负责人: Karl Scheidt
• 金额: $ 22.1万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2154820&HistoricalAwards=false
• 关键词: Catalytic; Synthesis; Saturated; Heterocycles

With the support of the Chemical Synthesis (SYN) program in the Division of Chemistry, Professor Karl Scheidt of Northwestern University is developing new catalytic transformations. The discovery and development of catalytic transformations to access saturated heterocycles described in the research plan is a crucial enterprise with broad potential impact on a wide range of scientific endeavors with material, biological and pharmacological endpoints. The proposed studies aim to facilitate access to chiral heterocyclic compounds through new bond-forming reactions. These new catalytic reactions will enable the efficient and sustainable construction of high value-added molecules and materials with broad impact on pharmaceutical research, material science, and biomedical research. By investigating these new approaches to heterocycles, early career scientists, including those with diverse backgrounds, will be trained and supported throughout their research experiences. To further the goals of this award, strong efforts will be made to increase the awareness of the role of modern science in our society with an emphasis on chemical science and catalysis. This proposal focuses on the continued development of new methods for synthesizing enantio-enriched saturated heterocycles. By merging new photocatalytic strategies with established catalysis platforms, the Scheidt group seeks to expand the compatibility and applicability of transformations developed earlier in the group. The integrated synthesis and cooperative catalysis approach taken in the group is a distinguishing feature of these studies. The discovery of new oxidative catalytic reactions driving innovative synthetic strategies is a crucial enterprise that enables synthesis to have a broad impact on a wide range of scientific endeavors. Throughout the proposed work, the Scheidt team will rely upon high throughput experimentation and catalytic reaction development to guide investigations. The results from this work will likely facilitate the improved design and rapid synthesis of target compounds via catalysis. The knowledge obtained from this research plan is expected to expand the number and classes of heterocycles accessible using oxidative, photocatalytic Prins strategies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学合成(SYN)项目的支持下，西北大学的卡尔·谢伊特教授正在开发新的催化转化。研究计划中描述的用于获得饱和杂环的催化转化的发现和开发是一项关键的事业，对材料、生物和药物终点的广泛科学努力具有广泛的潜在影响。建议的研究旨在通过新的成键反应促进手性杂环化合物的获得。这些新的催化反应将使高附加值分子和材料的高效和可持续构建成为可能，并对制药研究、材料科学和生物医学研究产生广泛影响。通过研究这些杂环化合物的新方法，早期职业科学家，包括那些具有不同背景的科学家，将在他们的整个研究经验中得到培训和支持。为了进一步实现该奖项的目标，将大力提高人们对现代科学在我们社会中的作用的认识，重点是化学科学和催化。这项建议的重点是继续开发合成富含对映体的饱和杂环的新方法。通过将新的光催化策略与现有的催化平台相结合，Scheidt小组寻求扩大该小组早些时候开发的转化的兼容性和适用性。该小组采用的综合合成和协同催化方法是这些研究的一个显著特点。新的氧化催化反应的发现推动了创新的合成策略，这是使合成能够对广泛的科学努力产生广泛影响的关键事业。在整个拟议的工作中，Scheidt团队将依靠高通量实验和催化反应开发来指导调查。这项工作的结果可能有助于通过催化改进目标化合物的设计和快速合成。从这项研究计划中获得的知识有望扩大使用氧化、光催化Prins策略获得的杂环的数量和类别。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。